Uterine artery pulsatility index: A predictor of methotrexate resistance in gestational trophoblastic neoplasia

British Journal of Cancer

Volumn 106, Issue 6, 2012, Pages 1089-1094

  Agarwal, R ^a   Harding, V ^a   Short, D ^a   Fisher, R A ^a   Sebire, N J ^a   Harvey, R ^a   Patel, D ^a   Savage, P M ^a   Lim, A K P ^a   Seckl, M J ^a  

^a IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

Author keywords

angiogenesis; drug resistance; low risk GTN; UAPI

Indexed keywords

DACTINOMYCIN; FOLINIC ACID; METHOTREXATE;

ADULT; ARTICLE; CANCER RESISTANCE; CANCER RISK; CANCER STAGING; DOPPLER FLOWMETRY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; PREDICTIVE VALUE; PRIORITY JOURNAL; PULSE WAVE; SCORING SYSTEM; TROPHOBLASTIC TUMOR; UTERINE ARTERY;

ADULT; ANTIMETABOLITES, ANTINEOPLASTIC; BLOOD FLOW VELOCITY; DRUG RESISTANCE, NEOPLASM; FEMALE; GESTATIONAL TROPHOBLASTIC DISEASE; HUMANS; LOGISTIC MODELS; METHOTREXATE; MULTIVARIATE ANALYSIS; PREGNANCY; PULSATILE FLOW; RISK FACTORS; STATISTICS, NONPARAMETRIC; UTERINE ARTERY;

EID: 84858282639     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2012.65     Document Type: Article

References (26)

1. Agarwal R, Strickland S, McNeish IA, Patel DC, Foskett M, Boultbee JE, Newlands ES, Seckl MJ (2002) Doppler ultrasonography of the uterine artery and the response to chemotherapy in patients with gestational trophoblastic tumors. Clin Cancer Res 8: 1142-1147 (Pubitemid 34517651)
2. Aghajanian C (2011) Treatment of low-risk gestational trophoblastic neoplasia. J Clin Oncol 29: 786-788
3. Bagshawe KD (1976) Risk and prognostic factors in trophoblastic neoplasia. Cancer 38: 1373-1385
4. Berndt S, Perrier d'Hauterive S, Blacher S, Pequeux C, Lorquet S, Munaut C, Applanat M, Herve MA, Lamande N, Corvol P, van den Brule F, Frankenne F, Poutanen M, Huhtaniemi I, Geenen V, Noel A, Foidart JM (2006) Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium. FASEB J 20: 2630-2632
5. Bower M, Newlands ES, Holden L, Short D, Brock C, Rustin GJ, Begent RH, Bagshawe KD (1997) EMA/CO for high-risk gestational trophoblastic tumors: results from a cohort of 272 patients. J Clin Oncol 15: 2636-2643 (Pubitemid 27289895)
6. Carmo CR, Lyons-Lewis J, Seckl MJ, Costa-Pereira AP (2011) A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells. PLoS One 6: e19861
7. Cole LA (2010) Biological functions of hCG and hCG-related molecules. Reprod Biol Endocrinol 8: 102
8. El-Helw LM, Coleman RE, Everard JE, Tidy JA, Horsman JM, Elkhenini HF, Hancock BW (2009) Impact of the revised FIGO/WHO system on the management of patients with gestational trophoblastic neoplasia. Gynecol Oncol 113: 306-311
9. Fontanini G, Bigini D, Vignati S, Basolo F, Mussi A, Lucchi M, Chine S, Angeletti CA, Harris AL, Bevilacqua G (1995) Microvessel count predicts metastatic disease and survival in non-small cell lung cancer. J Pathol 177: 57-63
10. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144: 646-674
11. Hollingsworth HC, Kohn EC, Steinberg SM, Rothenberg ML, Merino MJ (1995) Tumor angiogenesis in advanced stage ovarian carcinoma. Am J Pathol 147: 33-41
12. Kajii T, Ohama K (1977) Androgenetic origin of hydatidiform mole. Nature 268: 633-634 (Pubitemid 8227851)
13. Linderholm BK, Hellborg H, Johansson U, Skoog L, Lehtio J (2010) Vascular endothelial growth factor receptor 2 and downstream p38 mitogen-activated protein kinase are possible candidate markers of intrinsic resistance to adjuvant endocrine treatment in steroid receptor positive breast cancer. Breast Cancer Res Treat 125: 457-465
14. McGrath S, Short D, Harvey R, Schmid P, Savage PM, Seckl MJ (2010) The management and outcome of women with post-hydatidiform mole 'low-risk' gestational trophoblastic neoplasia, but hCG levels in excess of 100 000 IU l(-1). Br J Cancer 102: 810-814
15. McNeish IA, Strickland S, Holden L, Rustin GJ, Foskett M, Seckl MJ, Newlands ES (2002) Low-risk persistent gestational trophoblastic disease: outcome after initial treatment with low-dose methotrexate and folinic acid from 1992 to 2000. J Clin Oncol 20: 1838-1844 (Pubitemid 34273274)
16. Seckl MJ, Sebire NJ, Berkowitz RS (2010) Gestational trophoblastic disease. Lancet 376: 717-729
17. Shih Ie M (2007) Gestational trophoblastic neoplasia-pathogenesis and potential therapeutic targets. Lancet Oncol 8: 642-650
18. Shih Ie M (2011) Trophoblastic vasculogenic mimicry in gestational choriocarcinoma. Mod Pathol 24: 646-652
19. Siddiqui GK, Elmasry K, Wong Te Fong AC, Perrett C, Morris R, Crow JC, Maclean AB (2010) Prognostic significance of intratumoral vascular endothelial growth factor as a marker of tumour angiogenesis in epithelial ovarian cancer. Eur J Gynaecol Oncol 31: 156-159
20. Smith HO (2003) Gestational trophoblastic disease epidemiology and trends. Clin Obstet Gynecol 46: 541-556 (Pubitemid 37129522)
21. Szulman AE, Surti U (1978a) The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. Am J Obstet Gynecol 131: 665-671 (Pubitemid 8364343)
22. Szulman AE, Surti U (1978b) The syndromes of hydatidiform mole. II. Morphologic evolution of the complete and partial mole. Am J Obstet Gynecol 132: 20-27 (Pubitemid 8397361)
23. Weidner N (1993) Tumor angiogenesis: review of current applications in tumor prognostication. Semin Diagn Pathol 10: 302-313 (Pubitemid 24038034)
24. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini G (1992) Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst 84: 1875-1887 (Pubitemid 23004615)
25. Yang J, Liu X, Nyland SB, Zhang R, Ryland LK, Broeg K, Baab KT, Jarbadan NR, Irby R, Loughran Jr TP (2009) Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway. Blood 115: 51-60
26. Zygmunt M, Herr F, Keller-Schoenwetter S, Kunzi-Rapp K, Munstedt K, Rao CV, Lang U, Preissner KT (2002) Characterization of human chorionic gonadotropin as a novel angiogenic factor. J Clin Endocrinol Metab 87: 5290-5296 (Pubitemid 35316376)