Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: Implications for biological assembly and inhibitor development

Biochemical and Biophysical Research Communications

Volumn 419, Issue 3, 2012, Pages 485-489

  Pilka, Ewa S ^a   Kochan, Grazyna ^a   Oppermann, Udo ^a,b   Yue, Wyatt W ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

Author keywords

Bicarbonate; Carbonic anhydrase; Secretory protein

Indexed keywords

BICARBONATE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE VI; ISOENZYME; SECRETORY PROTEIN; UNCLASSIFIED DRUG; ZINC ION;

ARTICLE; CATALYSIS; CELLULAR DISTRIBUTION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; HYDRATION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTON TRANSPORT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; ISOENZYMES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; ZINC;

MAMMALIA;

EID: 84858281450     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.02.038     Document Type: Article

References (28)

1. Lindskog S. Structure and mechanism of carbonic anhydrase. Pharmacol. Ther. 1997, 74:1-20.
2. Supuran C.T. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat. Rev. Drug Discov. 2008, 7:168-181.
3. Hewett-Emmett D., Tashian R.E. Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families. Mol. Phylogenet. Evol. 1996, 5:50-77.
4. Coleman J.E. Mechanism of action of carbonic anhydrase. Subtrate, sulfonamide, and anion binding. J. Biol. Chem. 1967, 242:5212-5219.
5. Fernley R.T., Wright R.D., Coghlan J.P. A novel carbonic anhydrase from the ovine parotid gland. FEBS Lett. 1979, 105:299-302.
6. Karhumaa P., Leinonen J., Parkkila S., Kaunisto K., Tapanainen J., Rajaniemi H. The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk. Proc. Natl. Acad. Sci. USA 2001, 98:11604-11608.
7. Ogawa Y., Matsumoto K., Maeda T., Tamai R., Suzuki T., Sasano H., Fernley R.T. Characterization of lacrimal gland carbonic anhydrase VI. J. Histochem. Cytochem. 2002, 50:821-827.
8. Feldstein J.B., Silverman D.N. Purification and characterization of carbonic anhydrase from the saliva of the rat. J. Biol. Chem. 1984, 259:5447-5453.
9. Leinonen J.S., Saari K.A., Seppanen J.M., Myllyla H.M., Rajaniemi H.J. Immunohistochemical demonstration of carbonic anhydrase isoenzyme VI (CA VI) expression in rat lower airways and lung. J. Histochem. Cytochem. 2004, 52:1107-1112.
10. Kaseda M., Ichihara N., Nishita T., Amasaki H., Asari M. Immunohistochemistry of the bovine secretory carbonic anhydrase isozyme (CA-VI) in bovine alimentary canal and major salivary glands. J. Vet. Med. Sci. 2006, 68:131-135.
11. C.E. Smith, A. Nanci, P. Moffatt, Evidence by signal peptide trap technology for the expression of carbonic anhydrase 6 in rat incisor enamel organs, Eur J Oral Sci 114 Suppl 1 (2006) 147-153; discussion 164-145, 380-141.
12. Sok J., Wang X.Z., Batchvarova N., Kuroda M., Harding H., Ron D. CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI. Mol. Cell Biol. 1999, 19:495-504.
13. Kivela J., Parkkila S., Parkkila A.K., Leinonen J., Rajaniemi H. Salivary carbonic anhydrase isoenzyme VI. J. Physiol. 1999, 520(Pt 2):315-320.
14. Parkkila S., Parkkila A.K., Lehtola J., Reinila A., Sodervik H.J., Rannisto M., Rajaniemi H. Salivary carbonic anhydrase protects gastroesophageal mucosa from acid injury. Dig. Dis. Sci. 1997, 42:1013-1019.
15. Thatcher B.J., Doherty A.E., Orvisky E., Martin B.M., Henkin R.I. Gustin from human parotid saliva is carbonic anhydrase VI. Biochem. Biophys. Res. Commun. 1998, 250:635-641.
16. Henkin R.I., Martin B.M., Agarwal R.P. Efficacy of exogenous oral zinc in treatment of patients with carbonic anhydrase VI deficiency. Am. J. Med. Sci. 1999, 318:392-405.
17. Nishimori I., Onishi S., Vullo D., Innocenti A., Scozzafava A., Supuran C.T. Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines. Bioorg. Med. Chem. 2007, 15:5351-5357.
18. CCP4, The CCP4 suite: programs for protein crystallography, Acta Crystallogr. D Biol. Crystallogr. 50 (1994) 760-763.
19. McCoy A.J., Grosse-Kunstleve R.W., Storoni L.C., Read R.J. Likelihood-enhanced fast translation functions. Acta Crystallogr. D Biol. Crystallogr. 2005, 61:458-464.
20. Perrakis A., Harkiolaki M., Wilson K.S., Lamzin V.S. ARP/wARP and molecular replacement. Acta Crystallogr. D Biol. Crystallogr. 2001, 57:1445-1450.
21. Emsley P., Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 2004, 60:2126-2132.
22. Murshudov G.N., Vagin A.A., Dodson E.J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D Biol. Crystallogr. 1997, 53:240-255.
23. Whittington D.A., Waheed A., Ulmasov B., Shah G.N., Grubb J.H., Sly W.S., Christianson D.W. Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. Proc. Natl. Acad. Sci. USA 2001, 98:9545-9550.
24. Alterio V., Hilvo M., Di Fiore A., Supuran C.T., Pan P., Parkkila S., Scaloni A., Pastorek J., Pastorekova S., Pedone C., Scozzafava A., Monti S.M., De Simone G. Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. Proc. Natl. Acad. Sci. USA 2009, 106:16233-16238.
25. Lo Conte L., Chothia C., Janin J. The atomic structure of protein-protein recognition sites. J. Mol. Biol. 1999, 285:2177-2198.
26. Nishimori I., Minakuchi T., Onishi S., Vullo D., Scozzafava A., Supuran C.T. Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors. J. Med. Chem. 2007, 50:381-388.
27. Muller P., Kopke S., Sheldrick G.M. Is the bond-valence method able to identify metal atoms in protein structures?. Acta Crystallogr. D Biol. Crystallogr. 2003, 59:32-37.
28. Krebs J.F., Fierke C.A., Alexander R.S., Christianson D.W. Conformational mobility of His-64 in the Thr-200--Ser mutant of human carbonic anhydrase II. Biochemistry 1991, 30:9153-9160.