Snapshot hyperspectral imaging to measure oxygen saturation in the retina using fiber bundle and multi-slit spectrometer

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 8229, Issue , 2012, Pages

  Khoobehi, Bahram ^a   Khoobehi, Aurash ^a   Fournier, Paul ^b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Retina Health Center   (United States)

Author keywords

Fiberoptic bundle; Hyperspectral imaging; Optic nerve head; Oxygen tension

Indexed keywords

3-DIMENSIONAL REPRESENTATION; FIBER ARRAY; FIBER BUNDLES; FIELD OF VIEWS; FUNDUS CAMERA; HYPERSPECTRAL IMAGING; INDIVIDUAL FIBERS; INNOVATIVE TECHNOLOGY; LIGHT EXPOSURE; OPTIC NERVE HEAD; OXYGEN SATURATION; OXYGEN TENSION; SINGLE EXPOSURE; SNAPSHOT HYPERSPECTRAL IMAGING; SPATIAL INFORMATIONS; SPATIAL RESOLUTION; SPECTRAL COMPONENTS; TWO-DIMENSIONAL ARRAYS;

CAMERAS; EYE PROTECTION; HEMOGLOBIN; OPTICAL DATA PROCESSING; OPTICAL VARIABLES MEASUREMENT; OXYGEN; SPECTROMETERS; SPECTROMETRY; TISSUE;

FIBERS;

EID: 84858267686     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.910056     Document Type: Conference Paper

References (23)

1. Stefansson, E., Jensen, P.K., Eysteinsson, T., Bang, K., Kiilgaard, J.F., Dollerup, J., Scherfig, E. and la Cour, M. "Optic nerve oxygen tension in pigs and the effect of carbonic anhydrase inhibitors." Invest. Ophthalmol. Vis. Sci. 40(11), 2756-2761 (1999). PMID: 10509677. (Pubitemid 29455511)
2. Buerk, D.G., Atochin, D.N. and Riva, C.E. "Simultaneous tissue pO2, nitric oxide, and laser Doppler blood flow measurements during neuronal activation of optic nerve." Adv. Exp. Med. Biol. 454, 159-164 (1998). PMID: 9889888. (Pubitemid 29005526)
3. Cranstoun, S.D., Riva, C.E., Munoz, J.L. and Pournaras, C.J. "Continuous measurements of intra-vascular pO2 in the pig optic nerve head." Klin. Monatsbl. Augenheilkd. 210(5), 313-315 (1997). PMID: 9230497. (Pubitemid 27405048)
4. Linsenmeier, R.A. "Effects of light and darkness on oxygen distribution and consumption in the cat retina, " J. Gen. Physiol. 88(4), 521-542 (1986). PMID: 3783124. (Pubitemid 17172465)
5. Riva, C.E., Pournaras, C.J., Poitry-Yamate, C.L. and Petrig, B.L. "Rhythmic changes in velocity, volume, and flow of blood in the optic nerve head tissue." Microvasc. Res. 40(1), 36-45 (1990). PMID: 2144606. (Pubitemid 20227367)
6. Blumenroder, S., Augustin, A.J. and Koch, F.H.J. "The influence of intraocular pressure and systemic oxygen tension on the intravascular pO2 of the pig retina as measured with phosphorescence imaging" Surv. Ophthalmol. 42(Suppl 1), S118-S126 (1997). PMID: 9603297.
7. Shonat, R.D., Wilson, D.F., Riva, C.E. and Cranstoun, S.D. "Effect of acute increases in intraocular pressure on intravascular optic nerve oxygen tension in cats" Invest. Ophthalmol. Vis. Sci. 33(11), 3174-3180 (1992). PMID: 1399424.
8. Vanderkooi, J.M. and Berger, J.W. "Excited triplet states used to study biological macromolecules at room temperature." Biochem. Biophys. Acta 976(1), 1-27 (1989). PMID: 2669975.
9. Khoobehi, B., Beach, J.M. and Kawano, H. "Hyperspectral imaging for measurement of oxygen saturation in the optic nerve head." Invest. Ophthalmol. Vis. Sci. 45(5), 1464-1472 (2004). PMID: 15111603. (Pubitemid 38859326)
10. Beach, J.M., Schwenzer, K.J., Srinivas, S., Kim, D. and Tiedeman, J.S. "Oximetry of retinal vessels by dualwavelength imaging: calibration and influence of pigmentation." J. Appl. Physiol. 86(2), 748-758 (1999). PMID: 9931217. (Pubitemid 29075834)
11. Crittin, M., Schmidt, H. and Riva, C.E. "Hemoglobin oxygen saturation (So2) in the human ocular fundus measured by reflectance oximetry: preliminary data in retinal veins." Klin. Monatsbl. Augenheilkd. 219(4), 289-291 (2002). PMID: 12022020. (Pubitemid 34625238)
12. Delori, F.C. "Noninvasive technique for oximetry of blood in retinal vessels, " Appl. Opt. 27(6), 1113-1125 (1988). (Pubitemid 18093264)
13. Hickam, J.B., Frayser, R. and Ross, J.C. "A study of retinal venous blood oxygen saturation in human subjects by photographic means." Circulation. 27, 375-385 (1963). PMID: 13961118.
14. Hickam, J. and Frayser, R. "Studies of the retinal circulation in man: observations on vessel diameter, arteriovenous oxygen difference, and mean circulation time." Circulation. 33(2), 302-316 (1966).
15. Schweitzer, D., Hammer, M., Kraft, J., Thamm, E., Konigsdorffer, E. and Strobel, J. "In vivo measurement of the oxygen saturation of retinal vessels in healthy volunteers." IEEE Trans. Biomed. Eng. 46(12), 1454-1465 (1999). PMID: 10612903.
16. Schweitzer, D., Thamm, E., Hammer, M. and Kraft, J. "A new method for the measurement of oxygen saturation at the human ocular fundus." Int. Ophthalmol. 23(4-6), 347-353 (2001). PMID: 11944861. (Pubitemid 34256601)
17. Tiedeman, J.S., Kirk, S.E., Srinivas, S. and Beach, J.M. "Retinal oxygen consumption during hyperglycemia in patients with diabetes without retinopathy." Ophthalmology. 105(1), 31-36 (1998). PMID: 9442776. (Pubitemid 28070599)
18. Hardarson, S.H., Harris, A., Karlsson, R.A., Halldorsson, G.H., Kagemann, L., Rechtman, E., Zoega, G.M., Eysteinsson, T., Benediktsson, J.A., Thorsteinsson, A., Jensen, P.K., Beach, J. and Stefansson, E. "Automatic retinal oximetry." Invest. Ophthalmol. Vis. Sci. 47(11), 5011-5016 (2006). PMID: 17065521. (Pubitemid 46586407)
19. Delori, F.C. "Reflectometry measurements of the optic disc blood volume, " in [Ocular Blood Flow in Glaucoma. Means, Methods, and Measurements] G.N. Lambrou and E.L. Greve, Eds., Kugler and Ghedini, Berkeley, CA, pp 155-163, 1989.
20. Delori, F.C. and Pflibsen, K.P. "Spectral reflectance of the human ocular fundus." Appl. Optics. 28(6), 1061- 1077 (1989).
21. Berkowitz, B.A. "Adult and newborn rat inner retinal oxygenation during carbogen and 100% oxygen breathing: Comparison using magnetic resonance imaging delta PO2 mapping." Invest. Ophthalmol. Vis. Sci. 37(10), 2089-2098 (1996). PMID: 8814148. (Pubitemid 26321702)
22. Berkowitz, B.A., Kowluru, R.A., Frank, R.N., Kern, T.S., Hohman, T.C. and Prakash, M. "Subnormal retinal oxygenation response precedes diabetic-like retinopathy." Invest. Ophthalmol. Vis. Sci. 40(9), 2100-2105 (1999). PMID: 10440266. (Pubitemid 29365175)
23. Beach, J.M., Ning, J. and Khoobehi, B. "Oxygen saturation in optic nerve head structures by hyperspectral image analysis." Curr. Eye Res. 32(2), 161-170 (2007). PMID: 17364749. (Pubitemid 46328432)