Role of in vitro stimulation with lipopolysaccharide on T-cell activation in HIV-infected antiretroviral-treated patients

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Tincati, Camilla ^a   Bellistrì, Giusi M ^a   Ancona, Giuseppe ^a   Merlini, Esther ^a   D'Arminio Monforte, Antonella ^a   Marchetti, Giulia ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; HLA DR ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; KI 67 ANTIGEN; LIPOPOLYSACCHARIDE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPHENOTYPING; LYMPHOCYTE CULTURE; MALE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME; CASE CONTROL STUDY; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; ITALY; LYMPHOCYTE ACTIVATION; MIDDLE AGED; VIROLOGY;

ADULT; ANTI-HIV AGENTS; ANTIGENS, CD38; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HIV INFECTIONS; HIV-1; HLA-DR ANTIGENS; HUMANS; IMMUNOPHENOTYPING; ITALY; KI-67 ANTIGEN; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED;

EID: 84858264465     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/935425     Document Type: Article

References (23)

1. Douek D. C., Disrupting T-cell homeostasis: how HIV-1 infection causes disease AIDS Reviews 2003 5 3 172 177 (Pubitemid 37336634)
2. Douek D. C., Roederer M., Koup R. A., Emerging concepts in the immunopathogenesis of AIDS Annual Review of Medicine 2009 60 471 484
3. Brenchley J. M., Price D. A., Schacker T. W., Asher T. E., Silvestri G., Rao S., Kazzaz Z., Bornstein E., Lambotte O., Altmann D., Blazar B. R., Rodriguez B., Teixeira-Johnson L., Landay A., Martin J. N., Hecht F. M., Picker L. J., Lederman M. M., Deeks S. G., Douek D. C., Microbial translocation is a cause of systemic immune activation in chronic HIV infection Nature Medicine 2006 12 12 1365 1371 (Pubitemid 44924494)
4. Marchetti G., Bellistri G. M., Borghi E., Tincati C., Ferramosca S., La Francesca M., Morace G., Gori A., Monforte A. D., Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy AIDS 2008 22 15 2035 2044
5. Marchetti G., Gori A., Casabianca A., Magnani M., Franzetti F., Clerici M., Perno C. F., Monforte A. D. A., Galli M., Meroni L., Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART AIDS 2006 20 13 1727 1736 (Pubitemid 44299364)
6. Jiang W., Lederman M. M., Hunt P., Sieg C. F., Haley K., Rodriguez B., Landay A., Martin J., Sinclair E., Asher A. I., Deeks S. G., Douek D. C., Brenchley J. M., Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection Journal of Infectious Diseases 2009 199 8 1177 1185
7. Funderburg N., Luciano A. A., Jiang W., Rodriguez B., Sieg S. F., Lederman M. M., Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis PLoS One 2008 3 4
8. Giorgi J. V., Hultin L. E., McKeating J. A., Johnson T. D., Owens B., Jacobson L. P., Shih R., Lewis J., Wiley D. J., Phair J. P., Wolinsky S. M., Detels R., Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage Journal of Infectious Diseases 1999 179 4 859 870 (Pubitemid 29159331)
9. Giorgi J. V., Lyles R. H., Matud J. L., Yamashita T. E., Mellors J. W., Hultin L. E., Jamieson B. D., Margolick J. B., Rinaldo C. R., Phair J. P., Detels R., Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection Journal of Acquired Immune Deficiency Syndromes 2002 29 4 346 355 (Pubitemid 34288887)
10. Liu Z., Cumberland W. G., Hultin L. E., Prince H. E., Detels R., Giorgi J. V., Elevated CD38 antigen expression on CD8+ T cells Is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the multicenter AIDS Cohort study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1997 16 2 83 92
11. Deeks S. G., Kitchen C. M. R., Liu L., Guo H., Gascon R., Narvez A. B., Hunt P., Martin J. N., Kahn J. O., Levy J., McGrath M. S., Hecht F. M., Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load Blood 2004 104 4 942 947 (Pubitemid 39038012)
12. Benito J. M., Zabay J. M., Gil J., Bermejo M., Escudero A., Snchez E., Fernndez-Cruz E., Quantitative alterations of the functionally distinct subsets of CD4 and CD8 T lymphocytes in asymptomatic HIV infection: changes in the expression of CD45RO, CD45RA, CD11b, CD38, HLA-DR, and CD25 antigens Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1997 14 2 128 135
13. Savarino A., Bottarel F., Malavasi F., Dianzani U., Role of CD38 in HIV-1 infection: an epiphenomenon of T-cell activation or an active player in virus/host interactions? AIDS 2000 14 9 1079 1089 (Pubitemid 30420650)
14. Mehta K., Shahid U., Malavasi F., Human CD38, a cell-surface protein with multiple functions FASEB Journal 1996 10 12 1408 1417
15. Scalzo-Inguanti K., Plebanski M., CD38 identifies a hypo-proliferative IL-13-secreting CD4+ T-cell subset that does not fit into existing naive and memory phenotype paradigms European Journal of Immunology 2011 41 5 1298 1308
16. Gazzola L., Tincati C., Bellistr G. M., Monforte A. D., Marchetti G., The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options Clinical Infectious Diseases 2009 48 3 328 337
17. Hunt P. W., Martin J. N., Sinclair E., Bredt B., Hagos E., Lampiris H., Deeks S. G., T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency vires-infected patients with sustained viral suppression during antiretroviral therapy Journal of Infectious Diseases 2003 187 10 1534 1543 (Pubitemid 36578959)
18. Estes J. D., Harris L. D., Klatt N. R., Tabb B., Pittaluga S., Paiardini M., Barclay G. R., Smedley J., Pung R., Oliveira K. M., Hirsch V. M., Silvestri G., Douek D. C., Miller C. J., Haase A. T., Lifson J., Brenchley J. M., Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections PLoS Pathogens 2010 6 8 49 50
19. Paiardini M., Pandrea I., Apetrei C., Silvestri G., Lessons learned from the natural hosts of HIV-related viruses Annual Review of Medicine 2009 60 485 495
20. Meditz A. L., Haas M. K., Folkvord J. M., Melander K., Young R., McCarter M., MaWhinney S., Campbell T. B., Lie Y., Coakley E., Levy D. N., Connick E., HLA-DR+ CD38+ CD4+ T lymphocytes have elevated CCR5 expression and produce the majority of R5-tropic HIV-1 RNA in vivo Journal of Virology 2011 85 19 10189 10200
21. Massanella M., Negredo E., Perez-Alvarez N., Puig J., Ruiz-Hernandez R., Bofill M., Clotet B., Blanco J., CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART AIDS 2010 24 7 959 968
22. Merlini E., Bai F., Bellistr G. M., Tincati C., d'Arminio Monforte A., Marchetti G., Evidence for polymicrobic flora translocating in peripheral blood of HIV-infected patients with poor immune response to antiretroviral therapy PLoS One 2011 6 4
23. Piconi S., Parisotto S., Rizzardini G., Passerini S., Terzi R., Argenteri B., Meraviglia P., Capetti A., Biasin M., Trabattoni D., Clerici M., Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders Blood 2011 118 12 3263 3272