Analysis of chaperone-assisted ubiquitylation

Methods in Molecular Biology

Volumn 832, Issue , 2012, Pages 473-487

  Dreiseidler, Michael ^a   Dick, Niko ^a   Höhfeld, Jörg ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Chaperone assisted degradation; CHIP; Hsc70; Hsp70; Protein quality control

Indexed keywords

BAG3 PROTEIN, HUMAN; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; RAF PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBE2D2 PROTEIN, HUMAN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

ANIMAL; ARTICLE; AUTOPHAGY; BIOSYNTHESIS; CELL LINE; HUMAN; METABOLISM; MOTH; PHYSIOLOGY; PROTEIN DEGRADATION; RAT; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOPHAGY; CELL LINE; HSC70 HEAT-SHOCK PROTEINS; HSP40 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MOTHS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-RAF; RATS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84858235815     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-474-2_34     Document Type: Article

References (6)

1. Young JC, Barral JM, Hartl, FU (2003) More than folding: Localized functions of cytosolic chaperones. Trends Biochem Sci 28 :541-547.
2. Arndt V, Rogon C, Höhfeld J (2007) To be, or not to be - molecular chaperones in protein degradation. Cell Mol Life Sci 64 :2525-2541.
3. Ehrlich ES, Wang T, Luo K, et al (2009) Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase. Proc Natl Acad Sci USA 106 :20330-20335.
4. Höhfeld J, Jentsch S (1997) GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J 16 :6209-6216.
5. Imai Y, Soda M, Hatakeyama S, et al (2002) CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell 10 :55-67.
6. Kettern N, Dreiseidler M, Tawo R, Höhfeld J (2010) Chaperone-assisted degradation: multiple paths to destruction. Biol Chem 391 :481-489.