Model-based design of rituximab dosage optimization in follicular non-Hodgkin's lymphoma

British Journal of Clinical Pharmacology

Volumn 73, Issue 4, 2012, Pages 597-605

  Ternant, David ^a,b,c   Cartron, Guillaume ^d,e   Hénin, Emilie ^f   Tod, Michel ^f   Girard, Pascal ^f   Paintaud, Gilles ^a,b,c  

^a UNIVERSITÉ DE TOURS   (France)

^b CNRS   (France)

^c UNIVERSITY HOSPITAL OF TOURS   (France)

^d UNIVERSITÉ DE MONTPELLIER   (France)

^e MONTPELLIER UNIVERSITY HOSPITAL   (France)

^f UNIVERSITÉ CLAUDE BERNARD LYON 1   (France)

Author keywords

Follicular lymphoma; PK PD modelling; Progression free survival; Rituximab; Trial simulation

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; FC GAMMA 3A RECEPTOR; FC RECEPTOR; PREDNISONE; RITUXIMAB; UNCLASSIFIED DRUG; VINCRISTINE SULFATE;

ARTICLE; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER SURVIVAL; CLINICAL TRIAL (TOPIC); DOSE CALCULATION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFICACY; FOLLICULAR LYMPHOMA; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HUMAN; MAINTENANCE DRUG DOSE; MAINTENANCE THERAPY; OPTIMAL DRUG DOSE; PHARMACOGENETICS; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; SENSITIVITY ANALYSIS; STATISTICAL MODEL; STUDY DESIGN;

ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTINEOPLASTIC AGENTS; CLINICAL TRIALS AS TOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LYMPHOMA, FOLLICULAR; LYMPHOMA, NON-HODGKIN; MODELS, BIOLOGICAL; POLYMORPHISM, GENETIC; RECEPTORS, IGG;

EID: 84858231117     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2011.04125.x     Document Type: Article

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