Reactivity of human convalescent sera with influenza virus hemagglutinin protein mutants at antigenic site A

Microbiology and Immunology

Volumn 56, Issue 2, 2012, Pages 99-106

  Nobusawa, Eri ^a   Omagari, Katsumi ^a   Nakajima, Setsuko ^a   Nakajima, Katsuhisa ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Antigenic drift; Hemagglutinin; Human sera

Indexed keywords

INFLUENZA VIRUS HEMAGGLUTININ; MONOCLONAL ANTIBODY; MUTANT PROTEIN;

ADOLESCENT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGENIC VARIATION; ARTICLE; BINDING AFFINITY; CHILD; CONTROLLED STUDY; CONVALESCENCE; CROSS REACTION; HUMAN; IMMUNOREACTIVITY; INFLUENZA A; INFLUENZA VIRUS; MOLECULAR PHYLOGENY; MUTATIONAL ANALYSIS; PHYLOGENETIC TREE; POINT MUTATION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SCHOOL CHILD; SITE DIRECTED MUTAGENESIS; VIRUS CELL INTERACTION; VIRUS IMMUNITY;

ADOLESCENT; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, VIRAL; CERCOPITHECUS AETHIOPS; CHILD; COS CELLS; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; MALE; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE ALIGNMENT;

ORTHOMYXOVIRIDAE;

EID: 84858215648     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2012.00412.x     Document Type: Article

References (21)

1. Webster R.G., Laver W.G. (1980) Determination of the number of nonoverlapping antigenic areas on Hong Kong (H3N2) influenza virus hemagglutinin with monoclonal antibodies and the selection of variants with potential epidemiological significance. Virology 104: 139-48.
2. Wiley D.C., Wilson I.A., Skehel J.J. (1981) Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 289: 373-8.
3. Underwood P.A. (1982) Mapping of antigenic changes in the haemagglutinin of Hong Kong influenza (H3N2) strains using a large panel of monoclonal antibodies. J Gen Virol 62:(Pt 1):153-69.
4. Couch R.B., Kasel J.A. (1983) Immunity to influenza in man. Annu Rev Microbiol 37: 529-49.
5. Dowdle W.R., Coleman M.T., Mostow S.R., Kaye H.S., Schoenbaum, S.C. (1973) Inactivated influenza vaccines. 2. Laboratory indices of protection. Postgrad Med J 49: 159-63.
6. Hobson D., Curry R.L., Beare A.S., Ward-Gardner A. (1972) The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses. J Hyg (Lond) 70: 767-77.
7. Epstein S.L., Misplon J.A., Lawson C.M., Subbarao E.K., Connors M., Murphy B.R. (1993) Beta 2-microglobulin-deficient mice can be protected against influenza A infection by vaccination with vaccinia-influenza recombinants expressing hemagglutinin and neuraminidase. J Immunol 150: 5484-93.
8. Gerhard W., Mozdzanowska K., Furchner M., Washko G., Maiese, K. (1997) Role of the B-cell response in recovery of mice from primary influenza virus infection. Immunol Rev 159: 95-103.
9. Palladino G., Mozdzanowska K., Washko G., Gerhard W. (1995) Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice. J Virol 69: 2075-81.
10. Wang M.L., Skehel J.J., Wiley D.C. (1986) Comparative analyses of the specificities of anti-influenza hemagglutinin antibodies in human sera. J Virol 57: 124-8.
11. Nakajima S., Nobusawa E., Nakajima K. (2000) Variation in response among individuals to antigenic sites on the HA protein of human influenza virus may be responsible for the emergence of drift strains in the human population. Virology 274: 220-31.
12. Wilson I.A., Cox N.J. (1990) Structural basis of immune recognition of influenza virus hemagglutinin. Annu Rev Immunol 8: 737-71.
13. Fleury D., Daniels R.S., Skehel J.J., Knossow M., Bizebard T. (2000) Structural evidence for recognition of a single epitope by two distinct antibodies. Proteins 40: 572-8.
14. Malby R.L., Tulip W.R., Harley V.R., Mckimm-Breschkin J.L., Laver W.G., Webster R.G., Colman P.M. (1994) The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody. Structure 2: 733-46.
15. Nobusawa E., Ishihara H., Morishita T., Sato K., Nakajima K. (2000) Change in receptor-binding specificity of recent human influenza A viruses (H3N2): a single amino acid change in hemagglutinin altered its recognition of sialyloligosaccharides. Virology 278: 587-96.
16. Sato K., Morishita T., Nobusawa E., Tonegawa K., Sakae K., Nakajima S., Nakajima K. (2004) Amino-acid change on the antigenic region B1 of H3 haemagglutinin may be a trigger for the emergence of drift strain of influenza. A virus J Epidemiol Infect 132: 399-406.
17. Nakajima S., Nakajima K., Nobusawa E., Zhao J., Tanaka S., Fukuzawa K. (2007) Comparison of epitope structures of H3HAs through protein modeling of influenza A virus hemagglutinin: mechanism for selection of antigenic variants in the presence of a monoclonal antibody. Microbiol Immunol 51: 1179-87.
18. Nakajima K., Nobusawa E., Tonegawa K., Nakajima S. (2003) Restriction of amino acid change in influenza A virus H3HA: comparison of amino acid changes observed in nature and in vitro. J Virol 77: 10088-98.
19. Nakajima K., Nobusawa E., Nagy A., Nakajima, S. (2005) Accumulation of amino acid substitutions promotes irreversible structural changes in the hemagglutinin of human influenza AH3 virus during evolution. J Virol 79: 6472-7.
20. Plotkin J.B., Dushoff J., Levin S.A. (2002) Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus. Proc Natl Acad Sci U S A 99: 6263-8.
21. Arnold J.J., Cameron C.E. (2004) Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+. Biochemistry 43: 5126-37.