Turning up the heat: Immune brinksmanship in the acute-phase response

Quarterly Review of Biology

Volumn 87, Issue 1, 2012, Pages 3-18

  LeGrand, Edmund Kenwood ^a   Alcock, Joe ^b  

^a UNIVERSITY OF TENNESSEE   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Acute phase response; Anorexia; Evolution; Fever; Infection; Stress

Indexed keywords

ACUTE PHASE RESPONSE; ANIMAL; HOST PATHOGEN INTERACTION; HUMAN; INNATE IMMUNITY; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; REVIEW;

ACUTE-PHASE REACTION; ANIMALS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; STRESS, PHYSIOLOGICAL;

EID: 84858206358     PISSN: 00335770     EISSN: None     Source Type: Journal    
DOI: 10.1086/663946     Document Type: Review

References (106)

1. Adamo S. A. 1998. The specificity of behavioral fever in the cricket Acheta domesticus. Journal of Parasitology 84:529-533.
2. Adamo S. A., Fidler T. L., Forestell C. A. 2007. Illnessinduced anorexia and its possible function in the caterpillar, Manduca sexta. Brain, Behavior, and Immunity 21:292-300.
3. Adamson J. W. 2008. The anemia of inflammation/ malignancy: mechanisms and management. Hematology: American Society of Hematology Education Program Book 2008:159-165.
4. Aubert A. 1999. Sickness and behaviour in animals: a motivational perspective. Neuroscience and Biobehavioral Reviews 23:1029-1036.
5. Aydemir T. B., Liuzzi J. P., McClellan S., Cousins R. J. 2009. Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells. Journal of Leukocyte Biology 86:337-348.
6. Bashford C. L., Menestrina G., Henkart P. A., Pasternak C. A. 1988. Cell damage by cytolysin. Spontaneous recovery and reversible inhibition by divalent cations. Journal of Immunology 141:3965-3974.
7. Bauer S., Groh V., Wu J., Steinle A., Phillips J. H., Lanier L. L., Spies T. 1999. Activation of NK cells and T cells by NKG2D, a receptor for stressinducible MICA. Science 285:727-729.
8. Beard J. L. 2001. Iron biology in immune function, muscle metabolism and neuronal functioning. Journal of Nutrition 131:568S-580S.
9. Begum N. A., Kobayashi M., Moriwaki Y., Matsumoto M., Toyoshima K., Seya T. 2002. Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zntransporter and Zn-metalloprotease signatures. Genomics 80:630-645.
10. Beisel W. R. 1995. Herman Award Lecture, 1995: infection-induced malnutrition-from cholera to cytokines. American Journal of Clinical Nutrition 62: 813-819.
11. Blatteis C. M. 2006. Endotoxic fever: new concepts of its regulation suggest new approaches to its management. Pharmacology and Therapeutics 111:194-223.
12. Boddey J. A., Hodder A. N., Günther S., Gilson P. R., Patsiouras H., Kapp E. A., Pearce J. A., de Koning-Ward T. F., Simpson R. J., Crabb B. S., Cowman A. F. 2010. An aspartyl protease directs malaria effector proteins to the host cell. Nature 463:627-631.
13. Boer V. M., Crutchfield C. A., Bradley P. H., Botstein D., Rabinowitz J. D. 2010. Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations. Molecular Biology of the Cell 21:198-211.
14. Bone R. C., Grodzin C. J., Balk R. A. 1997. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 112:235-243.
15. Calabrese E. J. 2008. Converging concepts: adaptive response, preconditioning, and the Yerkes-Dodson Law are manifestations of hormesis. Ageing Research Reviews 7:8-20.
16. Calderwood S. K., Khaleque M. A., Sawyer D. B., Ciocca D. R. 2006. Heat shock proteins in cancer: chaperones of tumorigenesis. Trends in Biochemical Sciences 31:164-172.
17. Carlsen E., Andersson A.-M., Petersen J. H., Skakkebæk N. E. 2003. History of febrile illness and variation in semen quality. Human Reproduction 18: 2089-2092.
18. Cellier M. F., Courville P., Campion C. 2007. Nramp1 phagocyte intracellular metal withdrawal defense. Microbes and Infection 9:1662-1670.
19. Chai F., Truong-Tran A. Q., Ho L. H., Zalewski P. D. 1999. Regulation of caspase activation and apoptosis by cellular zinc fluxes and zinc deprivation: a review. Immunology and Cell Biology 77:272-278.
20. Chandra R. K. 1976. Nutrition as a critical determinant in susceptibility to infection. World Review of Nutrition and Dietetics 25:166-188.
21. Chen Z., Odstrcil E. A., Tu B. P., McKnight S. L. 2007. Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity. Science 316:1916-1919.
22. Chillakuru R. A., Ryu D. D. Y., Yilma T. 1991. Propagation of recombinant vaccinia virus in HeLa cells: adsorption kinetics and replication in batch cultures. Biotechnology Progress 7:85-92.
23. Combes A., McTiernan C., Brooks S. S., Feldman A. M. 2001. UV light synergistically enhances the cardiotoxic effects of interleukin 1β through peroxynitrite formation. Journal of Cardiac Failure 7:165-175.
24. Corbin B. D., Seeley E. H., Raab A., Feldmann J., Miller M. R., Torres V. J., Anderson K. L., Dattilo B. M., Dunman P. M., Gerads R., Caprioli R. M., Nacken W., Chazin W. J., Skaar E. P. 2008. Metal chelation and inhibition of bacterial growth in tissue abscesses. Science 319:962-965.
25. Cousins R. J., Leinart A. S. 1988. Tissue-specific regulation of zinc metabolism and metallothionein genes by interleukin 1. FASEB Journal 2:2884-2890.
26. Cramer T., Yamanishi Y., Clausen B. E., Förster I., Pawlinski R., Mackman N., Haase V. H., Jaenisch R., Corr M., Nizet V., Firestein G. S., Gerber H.-P., Ferrara N., Johnson R. S. 2003. HIF-1α is essential for myeloid cell-mediated inflammation. Cell 112: 645-657.
27. Curi R., Lagranha C. J., Doi S. Q., Sellitti D. F., Procopio J., Pithon-Curi T. C., Corless M., Newsholme P. 2005. Molecular mechanisms of glutamine action. Journal of Cellular Physiology 204:392-401.
28. Dantzer R. 2001. Cytokine-induced sickness behavior: where do we stand? Brain, Behavior, and Immunity 15:7-24.
29. Dardenne M. 2002. Zinc and immune function. European Journal of Clinical Nutrition 56 (Supplement 3):S20-S23.
30. Edwards M. J. 2006. Review: Hyperthermia and fever during pregnancy. Birth Defects Research, Part A: Clinical and Molecular Teratology 76:507-516.
31. Espat N. J., Moldawer L. L., Copeland E. M. Iii. 1995. Cytokine-mediated alterations in host metabolism prevent nutritional repletion in cachectic cancer patients. Journal of Surgical Oncology 58:77-82.
32. Exton M. S. 1997. Infection-induced anorexia: active host defence strategy. Appetite 29:369-383.
33. Fischbach M. A., Lin H., Liu D. R., Walsh C. T. 2006. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nature Chemical Biology 2:132-138.
34. Forchhammer K. 2007. Glutamine signalling in bacteria. Frontiers in Bioscience 12:358-370.
35. Foster J. R. 2000. Cell death and cell proliferation in the control of normal and neoplastic tissue growth. Toxicologic Pathology 28:441-446.
36. Gabay C., Kushner I. 1999. Acute-phase proteins and other systemic responses to inflammation. New England Journal of Medicine 340:448-454.
37. Giaccia A. J., Simon M. C., Johnson R. 2004. The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes & Development 18:2183-2194.
38. Gophna U., Ron E. Z. 2003. Virulence and the heat shock response. International Journal of Medical Microbiology 292:453-461.
39. Grasl-Kraupp B., Bursch W., Ruttkay-Nedecky B., Wagner A., Lauer B., Schulte-Hermann R. 1994. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proceedings of the National Academy of Sciences of the United States of America 91:9995-9999.
40. Green D. R., Kroemer G. 2009. Cytoplasmic functions of the tumour suppressor p53. Nature 458:1127-1130.
41. Hällgren R., Feltelius N., Lindh U. 1987. Redistribution of minerals and trace elements in chronic inflammation-a study on isolated blood cells from patients with ankylosing spondylitis. Journal of Rheumatology 14:548-553.
42. Hart B. L. 1988. Biological basis of the behavior of sick animals. Neuroscience and Biobehavioral Reviews 12:123-137.
43. Hasday J. D., Fairchild K. D., Shanholtz C. 2000. The role of fever in the infected host. Microbes and Infection 2:1891-1904.
44. Hempe J. M., Carlson J. M., Cousins R. J. 1991. Intestinal metallothionein gene expression and zinc absorption in rats are zinc-responsive but refractory to dexamethasone and interleukin 1α. Journal of Nutrition 121:1389-1396.
45. Henderson B., Allan E., Coates A. R. M. 2006. Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infection. Infection and Immunity 74:3693-3706.
46. Hussain S. N. A. 1998. Respiratory muscle dysfunction in sepsis. Molecular and Cellular Biochemistry 179: 125-134.
47. Jäättelä M. 1999. Heat shock proteins as cellular lifeguards. Annals of Medicine 31:261-271.
48. Jackson S. P., Bartek J. 2009. The DNA-damage response in human biology and disease. Nature 461: 1071-1078.
49. James S. J., Muskhelishvili L., Gaylor D. W., Turturro A., Hart R. 1998. Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging. Environmental Health Perspectives 106 (Supplement 1):307-312.
50. Karantza-Wadsworth V., Patel S., Kravchuk O., Chen G., Mathew R., Jin S., White E. 2007. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes & Development 21: 1621-1635.
51. Kehl-Fie T. E., Skaar E. P. 2010. Nutritional immunity beyond iron: a role for manganese and zinc. Current Opinion in Chemical Biology 14:218-224.
52. Khovidhunkit W., Kim M.-S., Memon R. A., Shigenaga J. K., Moser A. H., Feingold K. R., Grunfeld C. 2004. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. Journal of Lipid Research 45:1169-1196.
53. Kluger M. J., Rothenburg B. A. 1979. Fever and reduced iron: their interaction as a host defense response to bacterial infection. Science 203:374-376.
54. Kluger M. J., Kozak W., Conn C. A., Leon L. R., Soszynski D. 1998. Role of fever in disease. Annals of the New York Academy of Sciences 856:224-233.
55. Kü ltz D. 2005. Molecular and evolutionary basis of the cellular stress response. Annual Review of Physiology 67:225-257.
56. Kumar A., Brar R., Wang P., Dee L., Skorupa G., Khadour F., Schulz R., Parrillo J. E. 1999. Role of nitric oxide and cGMP in human septic seruminduced depression of cardiac myocyte contractility. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 276:R265-R276.
57. LeGrand E. K. 2000. Why infection-induced anorexia? The case for enhanced apoptosis of infected cells. Medical Hypotheses 54:597-602.
58. Li M., Zhang Y., Liu Z., Bharadwaj U., Wang H., Wang X., Zhang S., Liuzzi J. P., Chang S.-M., Cousins R. J., Fisher W. E., Brunicardi F. C., Logsdon C. D., Chen C., Yao Q. 2007. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proceedings of the National Academy of Sciences of the United States of America 104:18636-18641.
59. Lieu P. T., Heiskala M., Peterson P. A., Yang Y. 2001. The roles of iron in health and disease. Molecular Aspects of Medicine 22:1-87.
60. Lulloff S. J., Hahn B. L., Sohnle P. G. 2004. Fungal susceptibility to zinc deprivation. Journal of Laboratory and Clinical Medicine 144:208-214.
61. Marx J. J. M. 2002. Iron and infection: competition between host and microbes for a precious element. Best Practice & Research Clinical Haematology 15:411-426.
62. McInerney G. M., Kedersha N. L., Kaufman R. J., Anderson P., Liljeström P. 2005. Importance of eIF2α phosphorylation and stress granule assembly in alphavirus translation regulation. Molecular Biology of the Cell 16:3753-3763.
63. McLean J. E., Ruck A., Shirazian A., Pooyaei-Mehr F., Zakeri Z. F. 2008. Viral manipulation of cell death. Current Pharmaceutical Design 14:198-220.
64. Meinander A., Söderström T. S., Kaunisto A., Poukkula M., Sistonen L., Eriksson J. E. 2007. Fever-like hyperthermia controls T lymphocyte persistence by inducing degradation of cellular FLIPshort. Journal of Immunology 178:3944-3953.
65. Minami K., Tambe Y., Watanabe R., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T., Inoue H. 2007. Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway. Journal of Virology 81:11106-11115.
66. Moe G. W., Marin-Garcia J., Konig A., Goldenthal M., Lu X., Feng Q. 2004. In vivo TNF-α inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure. American Journal of Physiology: Heart and Circulatory Physiology 287:H1813-H1820.
67. Motley S. T., Morrow B. J., Liu X., Dodge I. L., Vitiello A., Ward C. K., Shaw K. J. 2004. Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment. Cellular Microbiology 6:849-865.
68. Muenzer J. T., Davis C. G., Dunne B. S., Unsinger J., Dunne W. M., Hotchkiss R. S. 2006. Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock 26:565-570.
69. Mühling J., Burchert D., Langefeld T. W., Matejec R., Harbach H., Engel J., Wolff M., Welters I. D., Fuchs M., Menges T., Krü ll M., Hempelmann G. 2007. Pathways involved in alanyl-glutamineinduced changes in neutrophil amino-and α-keto acid homeostasis or immunocompetence. Amino Acids 33:511-524.
70. Munck A., Guyre P. M., Holbrook N. J. 1984. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocrine Reviews 5:25-44.
71. Munger J., Bajad S. U., Coller H. A., Shenk T., Rabinowitz J. D. 2006. Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS Pathogens 2:e132.
72. Murray J., Murray A., Murray N. 1978. Anorexia: sentinel of host defense? Perspectives in Biology and Medicine 22:134-142.
73. Nagarsekar A., Greenberg R. S., Shah N. G., Singh I. S., Hasday J. D. 2008. Febrile-range hyperthermia accelerates caspase-dependent apoptosis in human neutrophils. Journal of Immunology 181: 2636-2643.
74. Ojicius D. M., Degani H., Mispelter J., Dautry-Varsat A. 1998. Enhancement of ATP levels and glucose metabolism during an infection by Chlamydia: NMR studies of living cells. Journal of Biological Chemistry 273:7052-7058.
75. Ostberg J. R., Kaplan K. C., Repasky E. A. 2002. Induction of stress proteins in a panel of mouse tissues by fever-range whole body hyperthermia. International Journal of Hyperthermia 18:552-562.
76. Posey J. E., Gherardini F. C. 2000. Lack of a role for iron in the Lyme disease pathogen. Science 288: 1651-1653.
77. Prasad A. S. 2007. Zinc: mechanisms of host defense. Journal of Nutrition 137:1345-1349.
78. Raffaghello L., Lee C., Safdie F. M., Wei M., Madia F., Bianchi G., Longo V. D. 2008. Starvationdependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proceedings of the National Academy of Sciences of the United States of America 105: 8215-8220.
79. Renckens R., van Westerloo D. J., Roelofs J. J. T. H., Pater J. M., Schultz M. J., Florquin S., van der Poll T. 2008. Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice. Critical Care Medicine 36:580-587.
80. Rohde M., Daugaard M., Jensen M. H., Helin K., Nylandsted J., Jäättelä M. 2005. Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes & Development 19:570-582.
81. Romanovsky A. A., Székely M. 1998. Fever and hypothermia: two adaptive thermoregulatory responses to systemic inflammation. Medical Hypotheses 50: 219-226.
82. Sandrini S. M., Shergill R., Woodward J., Muralikuttan R., Haigh R. D., Lyte M., Freestone P. P. 2010. Elucidation of the mechanism by which catecholamine stress hormones liberate iron from the innate immune defense proteins transferrin and lactoferrin. Journal of Bacteriology 192:587-594.
83. Schaible U. E., Kaufmann S. H. E. 2004. Iron and microbial infection. Nature Reviews Microbiology 2:946-953.
84. Scrimshaw N. S., Taylor C. E., Gordon J. E. 1968. Interactions of Nutrition and Infection. Geneva (Switzerland): World Health Organization.
85. Singh V., Aballay A. 2006. Heat shock and genetic activation of HSF-1 enhance immunity to bacteria. Cell Cycle 5:2443-2446.
86. Srivastava P. 2002. Roles of heat-shock proteins in innate and adaptive immunity. Nature Reviews Immunology 2:185-194.
87. Straub R. H., Cutolo M., Buttgereit F., Pongratz G. 2010. Energy regulation and neuroendocrineimmune control in chronic inflammatory diseases. Journal of Internal Medicine 267:543-560.
88. Sugarman B. 1983. Zinc and infection. Reviews of Infectious Diseases 5:137-147.
89. Suliman H. B., Carraway M. S., Piantadosi C. A. 2003. Postlipopolysaccharide oxidative damage of mitochondrial DNA. American Journal of Respiratory and Critical Care Medicine 167:570-579.
90. Suzuki S., Goncalves C. G., Meguid M. M. 2005. Catabolic outcome from non-gastrointestinal malignancy-related malabsorption leading to malnutrition and weight loss. Current Opinion in Clinical Nutrition and Metabolic Care 8:419-427.
91. + T cells by cytosolic mechanisms in dendritic cells versus vacuolar mechanisms in macrophages. Journal of Immunology 172:5277-5286.
92. + T cells. Journal of Immunology 173: 5130-5137.
93. Tran S. E. F., Meinander A., Holmström T. H., Rivero-Mü ller A., Heiskanen K. M., Linnau E. K., Courtney M. J., Mosser D. D., Sistonen L., Eriksson J. E. 2003. Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis. Cell Death and Differentiation 10:1137-1147.
94. Tredget E. E., Yu Y. M., Zhong S., Burini R., Okusawa S., Gelfand J. A., Dinarello C. A., Young V. R., Burke J. F. 1988. Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits. American Journal of Physiology: Endocrinology and Metabolism 255:E760-E768.
95. Tulapurkar M. E., Asiegbu B. E., Singh I. S., Hasday J. D. 2009. Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cells. Cell Stress and Chaperones 14:499-508.
96. Vallee B. L., Falchuk K. H. 1993. The biochemical basis of zinc physiology. Physiological Reviews 73:79-118.
97. Vander Heiden M. G., Cantley L. C., Thompson C. B. 2009. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029-1033.
98. Vogelstein B., Lane D., Levine A. J. 2000. Surfing the p53 network. Nature 408:307-310.
99. Weinberg E. D. 1984. Iron withholding: a defense against infection and neoplasia. Physiological Reviews 64:65-102.
100. Weinberg E. D. 2009. Iron availability and infection. Biochimica et Biophysica Acta 1790:600-605.
101. Weinstein I. B. 2000. Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis. Carcinogenesis 21:857-864.
102. Wintergerst E. S., Maggini S., Hornig D. H. 2007. Contribution of selected vitamins and trace elements to immune function. Annals of Nutrition & Metabolism 51:301-323.
103. Yeh S.-S., Blackwood K., Schuster M. W. 2008. The cytokine basis of cachexia and its treatment: are they ready for prime time? Journal of the American Medical Directors Association 9:219-236.
104. Yui S., Mikami M., Yamazaki M. 1995. Induction of apoptotic cell death in mouse lymphoma and human leukemia cell lines by a calcium-binding protein complex, calprotectin, derived from inflammatory peritoneal exudate cells. Journal of Leukocyte Biology 58:650-658.
105. Zarychanski R., Houston D. S. 2008. Anemia of chronic disease: a harmful disorder or an adaptive, beneficial response? Canadian Medical Association Journal 179: 333-337.
106. Zhang K., Kaufman R. J. 2008. From endoplasmicreticulum stress to the inflammatory response. Nature 454:455-462.