Dependence of the swelling behavior of a pH-responsive PEG-modified nanogel on the cross-link density

Polymer Journal

Volumn 44, Issue 3, 2012, Pages 240-244

  Tamura, Goshu ^a,b   Shinohara, Yuya ^a,b   Tamura, Atsushi ^c,e   Sanada, Yusuke ^b,d   Oishi, Motoi ^c   Akiba, Isamu ^b,d   Nagasaki, Yukio ^c   Sakurai, Kazuo ^b,d   Amemiya, Yoshiyuki ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d UNIVERSITY OF KITAKYUSHU   (Japan)

^e TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

drug delivery system; PEGylated nanogel; pH responsive swelling; small angle X ray scattering

Indexed keywords

CORE PART; CROSS-LINK DENSITIES; DRUG DELIVERY SYSTEM; NANOGELS; PH-RESPONSIVE; SMALL ANGLE X-RAY SCATTERING; STRUCTURAL CHANGE; SWELLING BEHAVIOR;

DRUG DELIVERY; SWELLING; X RAY SCATTERING;

NANOSTRUCTURED MATERIALS;

EID: 84858188566     PISSN: 00323896     EISSN: 13490540     Source Type: Journal    
DOI: 10.1038/pj.2011.123     Document Type: Article

References (32)

1. Ferrari, M. Cancer nanotechnology: Opportunities and challenges. Nat. Rev. Cancer 5, 161-171 (2005). (Pubitemid 40314948)
2. Davis, M. E., Chen, Z. G. & Shin, D. M. Nanoparticle therapeutics: An emerging treatment modality for cancer. Nat. Rev. Drug Discov. 7, 771-782 (2008).
3. Torchilin, V. P. Recent advances with liposomes as pharmaceutical carriers. Nat. Rev. Drug Discov. 4, 145-160 (2005). (Pubitemid 40282557)
4. Kataoka, K., Harada, A. & Nagasaki, Y. Block copolymer micelles for drug delivery: Design, characterization and biological significance. Adv. Drug Deliv. Rev. 47, 113-131 (2001). (Pubitemid 32209236)
5. Harris, J. M. & Chess, R. B. Effect of PEGylation on pharmaceuticals. Nat. Rev. Drug Discov. 2, 214-221 (2003). (Pubitemid 37361666)
6. Duncan, R. The dawning era of polymer therapeutics. Nat. Rev. Drug Discov. 2, 347-360 (2003). (Pubitemid 37361705)
7. Gref, R., Domb, A., Quellec, P., Blunk, T., Müller, R. H., Verbataz, J. M. & Langer, R. The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Adv. Drug Deliv. Rev. 16, 215-233 (1995).
8. Bontha, S., Kabanov, A. V. & Bronich, T. K. Polymermicelleswithcross- linkedioniccoresfordelivery of anticancer drugs. J. Control. Release 114, 163-174 (2006).
9. Monacelli, R. & Doretti, M. P. Separation of polyoxyethylene glycol in ice creams. Boll. Lab. Chim. Prov. (Bologna) 15, 235-238 (1964).
10. Kataoka, K., Kwon, G. S., Yokoyama, M., Okano, T. & Sakurai, Y. Block copolymer micelles as vehicles for drug delivery. J. Control. Release 24, 119-132 (1993). (Pubitemid 23161325)
11. Maeda, H., Wu, J., Sawa, T., Matsumura, Y. & Hori, K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review. J. Control. Release 65, 271-284 (2000). (Pubitemid 30122932)
12. Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387-6392 (1986). (Pubitemid 17221789)
13. Gruenberg, J. The endocytic pathway: A mosaic of domains. Nat. Rev. Mol. Cell Biol. 2, 721-730 (2001). (Pubitemid 33679834)
14. Clague, M. J. Molecular aspects of the endocytic pathway. Biochem. J. 336, 271-282 (1998). (Pubitemid 28564380)
15. Mukherjee, S., Ghosh, R. N. & Maxfield, F. R. Endocyosis. Physiol. Rev. 77, 759-803 (1997).
16. Duncan, R. Drug-polymer conjugates: Potential for improved chemotherapy. Anticancer Drugs 77, 175-210 (1992).
17. Oishi, M. & Nagasaki, Y. Synthesis, characterization, and biomedical applications of core-shell-type stimuli-responsive nanogels-Nanogel composed of poly[2-(N, N-diethylamino)ethyl methacrylate] core and PEG tethered chains. React. Funct. Polym. 67, 1311-1329 (2007). (Pubitemid 47562863)
18. Hayashi, H., Iijima, M., Kataoka, K. & Nagasaki, Y. pH-sensitive nanogel possessing reactive PEG tethered chains on the surface. Macromolecules 37, 5389-5396 (2004).
19. Oishi, M., Hayashi, H., Iijima, M. & Nagasaki, Y. Endosomal release and intracellular delivery of anticancer drugs using pH-sensitive PEGylated nanogels. J. Mater. Chem. 17, 3720-3725 (2007). (Pubitemid 47330703)
20. Oishi, M. & Nagasaki, Y. Stimuli-responsive smart nanogels for cancer diagnostics and therapy. Nanomedicine 5, 451-468 (2010).
21. Tamura, A., Oishi, M. & Nagasaki, Y. Efficient siRNA delivery based on PEGylated and partially quaternized polyamine nanogels: Enhanced gene silencing activity by the cooperative effect of tertiary and quaternary amino groups in the core. J. Control. Release 146, 378-387 (2010).
22. Tamura, A., Oishi, M. & Nagasaki, Y. Enhanced cytoplasmic delivery of siRNA using the stabilized polyion complexes based on PEGylated nanogels bearing cross-linked polyamine structure. Biomacromolecules 10, 1818-1827 (2009).
23. Glatter, O., Sherf, G., Schillen, K. & Brown, W. Characterization of a Poly(ethylene oxide)-Poly(propylene oxide) Triblock Copolymer (EO27-PO39-EO27) in aqueous solution. Macromolecules 27, 6046-6054 (1994).
24. Nakano, M., Deguchi, M., Matsumoto, K., Matsuoka, H. & Yamaoka, H. Self-Assembly of Poly(1,1-diethylsilabutane)-block-poly(2-hydroxyethyl methacrylate) block copolymer. 1. Micelle Formation and Micelle-Unimer-Reversed Micelle transition by solvent composition. Macromolecules 32, 7437-7443 (1999). (Pubitemid 30537689)
25. Pedersen, J. S., Svaneborg, C., Almdal, K., Hamley, I. W. & Young, R. N. A small-Angle neutron and X-ray contrast variation scattering study of the structure of block copolymer micelles: Corona shape and excluded volume interactions. Macromolecules 36, 416-433 (2003).
26. Riley, T., Heald, C. R., Stolnik, S., Garnett, M. C., Illum, L., Davis, S. S., King, S. M., Heenan, R. K., Purkiss, S. C., Barlow, R. J., Gellert, P. R. & Washington, C. Core-shell structure of PLA-PEG nanoparticles used for drug delivery. Langmuir 19, 8428-8435 (2003).
27. Akiba, I., Terada, N., Hashida, S., Sakurai, K., Sato, T., Shiraishi, K., Yokoyama, M., Masunaga, H., Ogawa, H., Ito, K. & Yagi, N. Encapsulation of a hydrophobic drug into a polymer-micelle core explored with synchrotron SAXS. Langmuir 26, 7544-7551 (2010).
28. Tamura, G., Shinohara, Y., Akiba, I., Tamura, A., Oishi, M., Nagasaki, Y., Sakurai, K. & Amemiya, Y. pH-responsive structural change of PEGylated amine-bearing nanogel explored by small angle X-ray scattering. J. Phys. Conf. Ser. 272, 012018 (2011).
29. Berne, B. J. & Pecora, R. Dynamic Light Scattering with Application to Chemistry, Biology and Physics, Dover Publications, New York, (2000).
30. Masunaga, H., Ogawa, H., Takano, T., Sasaki, S., Goto, S., Tanaka, T., Seike, T., Takahashi, S., Takeshita, K., Nobuteru, N., Ohashi, H., Ohata, T., Furukawa, Y., Matsushita, T., Ishizawa, Y., Yagi, N., Takata, M., Kitamura, H., Sakurai, K., Tashiro, K., Takahara, A., Amemiya, Y., Horie, K., Takenaka, M., Kanya, T., Jinnai, H., Okuda, H., Akiba, I., Takahashi, I., Yamamoto, K., Hikosaka, M., Sakurai, S., Shinohara, Y., Okada, A. & Sugihara, Y. Multipurpose soft-materials SAXS/WAXS/GISAXS beamline at SPring-8. Polym. J. 43, 471-477 (2011).
31. Fujisawa, T., Inoue, K., Oka, T., Iwamoto, H., Uruga, T., Kumasaka, T., Inoko, Y., Yagi, N., Yamamoto, M. & Ueki, T. Small-Angle X-ray scattering station at the SPring-8 RIKEN Beamline. J. Appl. Cryst. 33, 797-800 (2000). (Pubitemid 32120576)
32. Sakuragi, M., Kusuki, S., Hamada, E., Masunaga, H., Ogawa, H., Akiba, I. & Sakurai, K. Supramolecular structures of benzyl amine derivate/DNA complexes explored with synchrotron small angle X-ray scattering at SPring-8. J. Phys. Conf. Ser. 184, 012008 (2009).