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This excellent review article highlights the association between distinct macrophage subsets in the development of metabolic alterations in obesity
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Chawla, A.1
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Spite M, Serhan CN. Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. Circ Res 2010; 107:1170-1184. This review article provides a comprehensive overview of resolvin biosynthesis and the endogenous role of resolvins in regulating the resolution of inflammation.
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Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation
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This study elucidates a novel E-series resolvin biosynthetic pathway and highlights the role of E-series resolvins in regulating bacterial killing by phagocytes
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Oh SF, Pillai PS, Recchiuti A, et al. Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. J Clin Invest 2011; 121:569-581. This study elucidates a novel E-series resolvin biosynthetic pathway and highlights the role of E-series resolvins in regulating bacterial killing by phagocytes.
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J Clin Invest
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Oh, S.F.1
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17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli
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Results of this study demonstrate the mechanistic basis whereby D-series resolvins control bacterial killing by phagocytes
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Palmer CD, Mancuso CJ, Weiss JP, et al. 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. J Leukoc Biol 2011; 90:459-470. Results of this study demonstrate the mechanistic basis whereby D-series resolvins control bacterial killing by phagocytes.
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J Leukoc Biol
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Palmer, C.D.1
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28
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78650060401
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Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice
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This is the first study to demonstrate that endogenous levels of omega-3 fatty acids are depleted in insulin-sensitive tissues in obesity and that transgenic restoration of omega-3 fatty acid levels is protective in the context of metabolic disease and is associated with the production of proresolving lipid mediators
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White PJ, Arita M, Taguchi R, et al. Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice. Diabetes 2010; 59:3066-3073. This is the first study to demonstrate that endogenous levels of omega-3 fatty acids are depleted in insulin-sensitive tissues in obesity and that transgenic restoration of omega-3 fatty acid levels is protective in the context of metabolic disease and is associated with the production of proresolving lipid mediators.
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Diabetes
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White, P.J.1
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Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: A role for resolvins and protectins
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Gonzalez-Periz A, Horrillo R, Ferre N, et al. Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J 2009; 23:1946-1957.
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Gonzalez-Periz, A.1
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30
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79960187627
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Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice
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This is the first study to demonstrate a direct role of D-series resolvins in improving adipose tissue macrophage-mediated inflammation and hyperglycemia in obesity
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Hellmann J, Tang Y, Kosuri M, et al. Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. FASEB J 2011; 25:2399-2407. This is the first study to demonstrate a direct role of D-series resolvins in improving adipose tissue macrophage-mediated inflammation and hyperglycemia in obesity.
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FASEB J
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Hellmann, J.1
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31
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Resolvin D1 promotes resolution of acute inflammation and improves metabolic parameters in obese diabetic mice
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[abstract] P151. ATVB 2011 Scientific Sessions. Results of this study document that D-series resolvins restore defective macrophage phagocytosis in diabetes
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Spite M. Resolvin D1 promotes resolution of acute inflammation and improves metabolic parameters in obese diabetic mice. Arterioscler Thromb Vasc Biol [abstract] P151. ATVB 2011 Scientific Sessions. http://my.americanheart. org/idc/groups/ahamah-public/@wcm/@sop/documents/downloadable/ucm-428274.pdf. Results of this study document that D-series resolvins restore defective macrophage phagocytosis in diabetes.
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Arterioscler Thromb Vasc Biol
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Spite, M.1
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32
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77951033323
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Novel 14,21-dihydroxy-docosahexaenoic acids: Structures, formation pathways, and enhancement of wound healing
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This is the first study to document that a novel DHA-derived proresolving lipid mediator, 14S, 21R-diHDHA, plays a critical role in normal wound healing
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Lu Y, Tian H, Hong S. Novel 14,21-dihydroxy-docosahexaenoic acids: structures, formation pathways, and enhancement of wound healing. J Lipid Res 2010; 51:923-932. This is the first study to document that a novel DHA-derived proresolving lipid mediator, 14S, 21R-diHDHA, plays a critical role in normal wound healing.
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J Lipid Res
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Lu, Y.1
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33
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79953009005
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14S,21R-dihydroxydocosahexaenoic acid remedies impaired healing and mesenchymal stem cell functions in diabetic wounds
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This study highlights that a DHA-derived proresolving lipid mediator enhances angiogenesis in diabetic wounds
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Tian H, Lu Y, Shah SP, Hong S. 14S,21R-dihydroxydocosahexaenoic acid remedies impaired healing and mesenchymal stem cell functions in diabetic wounds. J Biol Chem 2011; 286:4443-4453. This study highlights that a DHA-derived proresolving lipid mediator enhances angiogenesis in diabetic wounds.
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J Biol Chem
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Tian, H.1
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34
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80053275279
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Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions
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This study demonstrates that altered biosynthesis of a proresolving lipid mediator in part underlies defective macrophage-mediated wound healing in diabetes
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Tian H, Lu Y, Shah SP, Hong S. Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions. Am J Pathol 2011; 179:1780-1791. This study demonstrates that altered biosynthesis of a proresolving lipid mediator in part underlies defective macrophage-mediated wound healing in diabetes.
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Am J Pathol
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Tian, H.1
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79956200036
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Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing
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Results of this study demonstrate that novel nanoparticle-based delivery systems for resolvins enhance keratinocyte wound healing
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Norling LV, Spite M, Yang R, et al. Cutting edge: humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol 2011; 186:5543-5547. Results of this study demonstrate that novel nanoparticle-based delivery systems for resolvins enhance keratinocyte wound healing.
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J Immunol
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Norling, L.V.1
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