Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors

Virulence

Volumn 3, Issue 1, 2012, Pages 72-76

  Bullard, Whitney ^a   Kieft, Rudo ^a   Capewell, Paul ^b   Veitch, Nicola J ^b   Macleod, Annette ^b   Hajduk, Stephen L ^a  

^a University of Georgia ^*  (United States)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

African sleeping sickness; Apolipoprotein l 1; Haptoglobin hemoglobin; Haptoglobin related protein; High density lipoprotein; Innate immunity; Trypanosome lytic factor

Indexed keywords

HAPTOGLOBIN; HAPTOGLOBIN HEMOGLOBIN RECEPTOR; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN; TRYPANOSOME LYTIC FACTOR 1; TRYPANOSOME LYTIC FACTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; ENDOCYTOSIS; INNATE IMMUNITY; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA GAMBIENSE;

TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI GAMBIENSE;

EID: 84858182708     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.4161/viru.3.1.18295     Document Type: Article

References (25)

1. Pays E. The variant surface glycoprotein as a tool for adaptation in African trypanosomes. Microbes Infect 2006; 8:930-937; PMID:16480910; http://dx.doi.org/10.1016/j.micinf.2005.10.002
2. Taylor JE, Rudenko G. Switching trypanosome coats: what's in the wardrobe. Trends Genet 2006; 22:614-620; PMID:16908087; http://dx.doi.org/10.1016/j.tig.2006.08.003
3. Rifkin MR. Identification of the trypanocidal factor in normal human serum: high-density lipoprotein. Proc Natl Acad Sci USA 1978; 75:3450-3454; PMID:210461; http://dx.doi.org/10.1073/pnas.75.7.3450
4. Hajduk SL, Moore DR, Vasudevacharya J, Siqueira H, Torri AF, Tytler EM, et al. Lysis of Trypanosoma brucei by a toxic subspecies of human high density lipoprotein. J Biol Chem 1989; 264:5210-5217; PMID:2494183
5. Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, van den Abbeele J, et al. Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature 2003; 422:83-87; PMID:12621437; http://dx.doi.org/10.1038/nature01461
6. Smith AB, Esko JD, Hajduk SL. Killing of trypanosomes by human haptoglobin related protein. Science 1995; 268:284-286; PMID:7716520; http://dx.doi.org/10.1126/science.7716520
7. Shiflett AM, Bishop JR, Pahwa A, Hajduk SL. Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes. J Biol Chem 2005; 80:32578-3285; PMID:16046400; http://dx.doi.org/10.1074/jbc.M503510200
8. Widener J, Nielsen MJ, Shiflett A, Moestrup S, Hajduk S. Hemoglobin is a co-factor of human trypanosome lytic factor. PLoS Pathog 2007; 3:1250-1261; PMID:17845074; http://dx.doi.org/10.1371/journal.ppat.0030129
9. Drain J, Bishop R, Hajduk SL. Haptoglobin-related protein mediates trypanosome lytic factor binding to trypanosomes. J Biol Chem2001; 276:30254-30260; PMID: 11352898; http://dx.doi.org/10.1074/jbc.M010198200
10. Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, et al. A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Science 2008; 320:677-681; PMID: 18451305; http://dx.doi.org/10.1126/science.1156296
11. Bishop JR, Shimamura M, Hajduk SL. Insight into the mechanism of trypanosome lytic factor-1 killing of Trypanosoma brucei brucei. Mol Biochem Parasitol 2001; 118:33-40; PMID:11704271; http://dx.doi.org/10.1016/S0166-6851(01)00361-9
12. Pérez-Morga D, Vanhollebeke B, Paturiaux-Hanocq F, Nolan DP, Lins L, Homble F, et al. Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. Science 2005; 309:469-472; PMID:16020735; http://dx.doi.org/10.1126/science.1114566
13. Molina-Portela MP, Samanovic M, Raper J. Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model. J Exp Med 2008; 205:1721-1728; PMID: 18606856; http://dx.doi.org/10.1084/jem.20071463
14. Molina-Portela MP, Lugli EB, Recio-Pinto E, Raper J. Trypanosome lytic factor, a subclass of high-density lipoprotein, forms cation-selective pores in membranes. Mol Biochem Parasitol 2005; 144:218-226; PMID: 16202458; http://dx.doi.org/10.1016/j.molbiopara.2005.08.018
15. Rifkin MR. Trypanosoma brucei: Biochemical and morphological studies of cytotoxicity caused by normal human serum. Exp Parasitol 1984; 58:81-93; PMID: 6745390; http://dx.doi.org/10.1016/0014-4894(84)90023-7
16. Vanhollebeke B, Lecordier L, Perez-Morga D, Amiguet-Vercher A, Pays E. Human serum lyses Trypanosoma brucei by triggering uncontrolled swelling of the parasite lysosome. J Eukaryot Microbiol 2007; 54:448-451; PMID:17910690; http://dx.doi.org/10.1111/j.1550-7408.2007.00285.x
17. Raper J, Fung R, Ghiso J, Nussenzweig V, Tomlinson S. Characterization of a novel trypanosome lytic factor in human serum. Infect Immun 1999; 67:1910-1996;PMID:10085035
18. Vanhollebeke B, Pays E. The trypanolytic factor of human serum; many ways to enter the parasite, a single way to kill. Mol Microbiol 2010; 76:806-814; PMID: 20398209; http://dx.doi.org/10.1111/j.1365-2958.2010.07156.x
19. De Greef C, Hamers R. The serum resistanceassociated (SRA) gene of Trypanosoma brucei rhodesiense encodes a variant surface glycoprotein-like protein. Mol Biochem Parasitol 1994; 68:277-184; PMID:7739673; http://dx.doi.org/10.1016/0166-6851(94)90172-4
20. Turner CMR, McLellan S, Lindergard LAG, Bisoni L, Tait A, MacLeod A. Human infectivity trait in Trypanosoma brucei: stability, heritability and relation to sra expression. Parasitology 2004; 129: 445-454; PMID:15521633; http://dx.doi.org/10.1017/S0031182004005906
21. Xong HV, Vanhamme L, Chamekh M, Chimfwembe CE, Van Den Abbeele J, Pays A, et al. A VSG expression siteassociated gene confers resistance to human serum in Trypanosoma rhodesiense. Cell 1998; 95:839-846; PMID: 9865701; http://dx.doi.org/10.1016/S0092-8674(00)81706-7
22. Stephens NA, Hajduk SL. Endosomal Localization of the serum resistance-associated protein in African trypanosomes confers human infectivity. Eukaryot Cell 2011; 10:1023-1033; PMID:21705681; http://dx.doi.org/10.1128/EC.05112-11
23. Kieft R, Capewell P, Turner CM, Veitch NJ, MacLeod A, Hajduk S. Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor. Proc Natl Acad Sci USA 2010; 107:16137-16141; PMID:20805508; http://dx.doi.org/10.1073/pnas.1007074107
24. Faulkner SD, Oli MW, Kieft R, Cotlin L, Widener J, Shiflett A, et al. In vitro generation of human high density lipoprotein resistant Trypanosoma brucei brucei. Eukaryot Cell 2006; 5:1276-1286; PMID:16896212; http://dx.doi.org/10.1128/EC.00116-06
25. Green HP, Pilar Molina Portela M, Jean EM, Lugli EB, Raper J. Evidence for a Trypanosoma brucei lipoprotein scavenger receptor. J Biol Chem 2003; 278:422-427; PMID:12401813; http://dx.doi.org/10.1074/jbc.M207215200