Antidiarrhoeal activity of leaf methanolic extract of Rauwolfia serpentina

Asian Pacific Journal of Tropical Biomedicine

Volumn 2, Issue 6, 2012, Pages 430-432

  Ezeigbo, I I ^a   Ezeja, M I ^a   Madubuike, K G ^a   Ifenkwe, D C ^a   Ukweni, I A ^a   Udeh, N E ^a   Akomas, S C ^a  

^a MICHAEL OKPARA UNIVERSITY OF AGRICULTURE   (Nigeria)

Author keywords

Antidiarrhoeal activity; Castor oil; Intestinal transit; Rauwolfia serpentina

Indexed keywords

ATROPINE; CASTOR OIL; DIPHENOXYLATE; METHANOL; RAUWOLFIA EXTRACT; ANTIDIARRHEAL AGENT; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIARRHEAL ACTIVITY; ARTICLE; BODY FLUID; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG POTENCY; EXPERIMENTAL MOUSE; FEMALE; HERBAL MEDICINE; INTESTINE TRANSIT TIME; INTESTINE WEIGHT; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; PLANT LEAF; PRIORITY JOURNAL; RAUWOLFIA; SOLVENT EXTRACTION; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; INTESTINE; ISOLATION AND PURIFICATION; PATHOLOGY;

MUS; RAUVOLFIA SERPENTINA;

ANIMALS; ANTIDIARRHEALS; DIARRHEA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INTESTINES; MICE; PLANT EXTRACTS; PLANT LEAVES; RAUWOLFIA;

EID: 84858167199     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2221-1691(12)60070-7     Document Type: Article

References (16)

1. Wardlaw T, Salama P, Brocklehurst C, Chopra M, Mason E. Diarrhoea: why children are still dying and what can be done. Lancet 2009: 375: 870-872.
2. Chidume FC, Gamaniel K, Amos S, Akah PA, Obodozie O. Pharmacological activities of the methanolic extract of Cassia nigricans leaf. Indian J Pharmacol 2001; 33: 350-356.
3. Ezeigbo II, Ejike CECC, Ezeja MI, Eneh O. Antioxidant and antidiarrhoeal activity of Manniophyton africanum leaf extract in mice. Cont J Anim Vet Res 2010; 2: 41-47.
4. Gandhimathi R, Saravana KA, Senthil-Kumar KK, Kusuma PK, Uma MJ. Pharmacological studies of anti-diarrhoeal activity of Guettarda speciosa (L.) in experimental animals. J Pharm Sci Res 2009; 1(2): 61-66.
5. de Wet H, Nkwanyana MN, van Vuuren SF. Ethnopharmacological communication medicinal plants used for the treatment of diarrhoea in Northern Maputaland, KwaZulu-Natal Province, South Africa. J Ethnopharmacol 2010; 130(2): 284-289.
6. Bhatara VS, Sharma JN, Gupta S, Gupta YK. Images in psychiatry. Rauwolfia serpentina: the first herbal antipsychotic. Am J Psychiatry 1997: 154(7): 894.
7. Stanford JL, Martin EJ, Brinton LA, Hoover RN. Rauwolfia use and breast cancer: a case-control study. J Natl Cancer Inst 1986; 76(5): 817-822.
8. Lorke D. A new approach to practical acute toxicity testing. Arch Toxicol 1983; 54: 275-287.
9. Adeyemi OO, Akindele AJ. Antidiarrhoeal activity of the ethyl acetate extract of Baphia nitida (Papilionaceae). J Ethnopharmacol 2008; 116(3): 407-412.
10. Yasmeen M, Prabhu B, Agashikar NV. Evaluation of the antidiarrhoeal activity of the leaves of Ixora coccinea Linn. in rats. J Clin Diagn Res 2010; 4(5): 3298-3303.
11. Akindele AJ, Adeyemi OO. Evaluation of the antidiarrhoeal activity of Byrosocarpus coccineus. J Ethnopharmacol 2006; 108(1): 20-25.
12. Bakare RI, Magbagbeola OA, Akinwande AI, Okunowo OW, Green M. Antidiarrhoeal activity of aqueous leaf extract of Momordica charantia in rats. J Pharmacognosy Phytother 2011; 3(1): 1-7.
13. Amabeoku GJ, Bamuamba K. Evaluation of the effects of Olea europaea L. subsp. africana (Mill.) P.S. green (Oleaceae) leaf methanol extract against castor oil-induced diarrhoea in mice. J Pharm Pharmacol 2010; 62(3): 368-373.
14. Viswanatha GLS, Hanumanthappa S, Krishnadas N, Rangappa S. Antidiarrheal effect of fractions from stem bark of Thespesia populnea in rodents: Possible antimotility and antisecretory mechanisms. Asian Pac J Trop Med 2011; 4(6): 451-456.
15. Palombo EA. Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of actions and effects on intestinal function. Phytother Res 2005; 20: 717-724.
16. Mohammed A, Ahmed H, Goji ADT, Okpanachi AO, Ezekiel I, Tanko Y. Preliminary anti-diarrhoeal activity of hydromethanolic extract of aerial part of Indigofera pulchra in rodents. Asian J Med Sci 2009; 1(2): 22-25.