High TNF-alpha and IL-8 levels predict low blood dendritic cell counts in primary cytomegalovirus infection

Journal of Clinical Virology

Volumn 53, Issue 4, 2012, Pages 360-363

  Varani, Stefania ^a   Rossini, Giada ^a   Mastroianni, Antonio ^b   Tammik, Charlotte ^c   Frascaroli, Giada ^d   Landini, Maria Paola ^a   Castellani, Gastone ^a   Söderberg Nauclér, Cecilia ^c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b MORGAGNI PIERANTONI HOSPITAL   (Italy)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Antigen presenting cells; Cytomegalovirus infection; Pro inflammatory cytokines

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DENDRITIC CELL; ENDOTHELIUM CELL; FEMALE; HUMAN; IMMUNOCOMPROMISED PATIENT; INFECTIOUS MONONUCLEOSIS; MALE; MYELOID DENDRITIC CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; VIRUS LOAD;

ADULT; AGED; ANTIGEN-PRESENTING CELLS; BLOOD; CYTOKINES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DENDRITIC CELLS; FEMALE; HUMANS; INFECTIOUS MONONUCLEOSIS; INFLAMMATION; INTERLEUKIN-8; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84858159482     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2011.12.028     Document Type: Article

References (25)

1. Ueno H., Klechevsky E., Morita R., Aspord C., Cao T., Matsui T., et al. Dendritic cell subsets in health and disease. Immunol Rev 2007, 219:118-142.
2. Sozzani S., Allavena P., D'Amico G., Luini W., Bianchi G., Kataura M., et al. Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties. J Immunol 1998, 161:1083-1086.
3. Varani S., Frascaroli G., Homman-Loudiyi M., Feld S., Landini M.P., Soderberg-Naucler C. Human cytomegalovirus inhibits the migration of immature dendritic cells by down-regulating cell-surface CCR1 and CCR5. J Leukoc Biol 2005, 77:219-228.
4. Beck K., Meyer-Konig U., Weidmann M., Nern C., Hufert F.T. Human cytomegalovirus impairs dendritic cell function: a novel mechanism of human cytomegalovirus immune escape. Eur J Immunol 2003, 33:1528-1538.
5. Moutaftsi M., Brennan P., Spector S.A., Tabi Z. Impaired lymphoid chemokine-mediated migration due to a block on the chemokine receptor switch in human cytomegalovirus-infected dendritic cells. J Virol 2004, 78:3046-3054.
6. Raftery M.J., Wieland D., Gronewald S., Kraus A.A., Giese T., Schonrich G. Shaping phenotype, function, and survival of dendritic cells by cytomegalovirus-encoded IL-10. J Immunol 2004, 173:3383-3391.
7. Chang W.L., Baumgarth N., Yu D., Barry P.A. Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality. J Virol 2004, 78:8720-8731.
8. Frascaroli G., Varani S., Mastroianni A., Britton S., Gibellini D., Rossini G., et al. Dendritic cell function in cytomegalovirus-infected patients with mononucleosis. J Leukoc Biol 2006, 79:932-940.
9. Varani S., Mastroianni A., Frascaroli G., Tammik C., Rahbar A., Christensson M., et al. Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection. Arthritis Rheum 2009, 60:1558-1562.
10. Revello M.G., Zavattoni M., Sarasini A., Percivalle E., Simoncini L., Gerna G. Human cytomegalovirus in blood of immunocompetent persons during primary infection: prognostic implications for pregnancy. J Infect Dis 1998, 177:1170-1175.
11. Sabado R.L., O'Brien M., Subedi A., Qin L., Hu N., Taylor E., et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 2010, 116:3839-3852.
12. Donaghy H., Pozniak A., Gazzard B., Qazi N., Gilmour J., Gotch F., et al. Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood 2001, 98:2574-2576.
13. Zhang Z., Chen D., Yao J., Zhang H., Jin L., Shi M., et al. Increased infiltration of intrahepatic DC subsets closely correlate with viral control and liver injury in immune active pediatric patients with chronic hepatitis B. Clin Immunol 2007, 122:173-180.
14. Ulsenheimer A., Gerlach J.T., Jung M.C., Gruener N., Wachtler M., Backmund M., et al. Plasmacytoid dendritic cells in acute and chronic hepatitis C virus infection. Hepatology 2005, 41:643-651.
15. Uehira K., Amakawa R., Ito T., Tajima K., Naitoh S., Ozaki Y., et al. Dendritic cells are decreased in blood and accumulated in granuloma in tuberculosis. Clin Immunol 2002, 105:296-303.
16. Kunitani H., Shimizu Y., Murata H., Higuchi K., Watanabe A. Phenotypic analysis of circulating and intrahepatic dendritic cell subsets in patients with chronic liver diseases. J Hepatol 2002, 36:734-741.
17. Semnani R.T., Mahapatra L., Dembele B., Konate S., Metenou S., Dolo H., et al. Expanded numbers of circulating myeloid dendritic cells in patent human filarial infection reflect lower CCR1 expression. J Immunol 2010, 185:6364-6372.
18. Dillon S.M., Robertson K.B., Pan S.C., Mawhinney S., Meditz A.L., Folkvord J.M., et al. Plasmacytoid and myeloid dendritic cells with a partial activation phenotype accumulate in lymphoid tissue during asymptomatic chronic HIV-1 infection. J Acquir Immune Defic Syndr 2008, 48:1-12.
19. Sallusto F., Schaerli P., Loetscher P., Schaniel C., Lenig D., Mackay C.R., et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol 1998, 28:2760-2769.
20. Duperray A., Mantovani A., Introna M., Dejana E. Endothelial cell regulation of leukocyte infiltration in inflammatory tissues. Mediators Inflamm 1995, 4:322-330.
21. Colvin B.L., Lau A.H., Schell A.M., Thomson A.W. Disparate ability of murine CD8alpha- and CD8alpha+ dendritic cell subsets to traverse endothelium is not determined by differential CD11b expression. Immunology 2004, 113:328-337.
22. Sozzani S., Luini W., Borsatti A., Polentarutti N., Zhou D., Piemonti L., et al. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. J Immunol 1997, 159:1993-2000.
23. Sallusto F., Palermo B., Lenig D., Miettinen M., Matikainen S., Julkunen I., et al. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur J Immunol 1999, 29:1617-1625.
24. Goldmacher V.S. Cell death suppression by cytomegaloviruses. Apoptosis 2005, 10:251-265.
25. Randolph-Habecker J., Iwata M., Torok-Storb B. Cytomegalovirus mediated myelosuppression. J Clin Virol 2002, 25(Suppl. 2):S51-S56.