Occupational causes of sarcoidosis

Current Opinion in Allergy and Clinical Immunology

Volumn 12, Issue 2, 2012, Pages 145-150

  Newman, Kira L ^a   Newman, Lee S ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Global Health and Health Disparities   (United States)

Author keywords

granuloma; nanoparticle; occupation; sarcoidosis; World Trade Center

Indexed keywords

ALUMINUM; ANTIGEN; BACTERIUM ANTIBODY; BARIUM; COBALT; COPPER; GOLD; INTERLEUKIN 12; NANOPARTICLE; TALC; TITANIUM; ZIRCONIUM;

ALLERGIC PNEUMONITIS; AMBIENT AIR; BACTERIUM CONTAMINATION; BERYLLIOSIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; ENVIRONMENTAL EXPOSURE; HUMAN; HYPERSENSITIVITY; IMMUNE RESPONSE; INFLAMMATION; LUNG GRANULOMA; MYCOBACTERIUM; OCCUPATIONAL EXPOSURE; ORNITHOSIS; PARTICULATE MATTER; PRIORITY JOURNAL; PROBABILITY; REVIEW; RISK FACTOR; SARCOIDOSIS; SILICOSIS; WORKPLACE;

ANIMALS; ANTIGENS, BACTERIAL; ANTIGENS, FUNGAL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; HYPERSENSITIVITY; MALE; MICE; MYCOBACTERIUM INFECTIONS; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; PARTICULATE MATTER; SARCOIDOSIS;

EID: 84858153565     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e3283515173     Document Type: Review

References (38)

1. Park J-H, Cox-Ganser JM. Mold exposure and respiratory health in damp indoor environments. Front Biosci 2011; 3:757-771.
2. Laney AS, Cragin LA, Blevins LZ, et al. Sarcoidosis, asthma, and asthma-like symptoms among occupants of a historically water-damaged office building. Indoor Air 2009; 19:83-90. This study is an interesting investigation of the contribution of mold contamination to the development of not only sarcoidosis, but also other immune-mediated respiratory disorders. Like other studies of its kind, there is emerging evidence that office building-related sarcoidosis occurs.
3. Iossifova YY, Cox-Ganser JM, Park J-H, et al. Lack of respiratory improvement following remediation of a water-damaged office building. Am J Ind Med 2011; 54:269-277. In this follow-up study of workers exposed to mold in a water-damaged building, researchers reexamined individuals after the building was cleaned. Unfortunately, there continued to be a high incidence of respiratory illness after remediation.
4. Terčelj M, Salobir B, Harlander M, et al. Fungal exposure in homes of patients with sarcoidosis: an environmental exposure study. Environ Health 2011; 10:8-12.
5. Terčelj M, Stopinšek S, Ihan A, et al. In vitro and in vivo reactivity to fungal cell wall agents in sarcoidosis. Clin Exp Immunol 2011; 166:87-93. This intriguing study showed that patients with sarcoidosis mount increased blood mononuclear cell cytokine responses to fungal cell wall antigens as compared with controls. Researchers also conducted sampling in patients' homes and found a positive correlation between high household fungal antigen levels and increased IL-6, IL-10, and IL-12 secretion.
6. + T lymphocytes from 31 sarcoidosis patients were exposed to mycobacterial antigens. Cells from 22 of the 31 patients responded to at least one epitope. Provocatively, the authors mention that some T cell responses disappeared when patients' clinical sarcoidosis resolved; however, they do not present data regarding this observation.
7. Roussel S, Rognon B, Barrera C, et al. Immuno-reactive proteins from Mycobacterium immunogenum useful for serodiagnosis of metalworking fluid hypersensitivity pneumonitis. Int J Med Microbiol 2011; 301:150-156.
8. Tillie-Leblond I, Grenouillet F, Reboux G, et al. Hypersensitivity pneumonitis and metalworking fluids contaminated by mycobacteria. Eur Respir J 2011; 37:640-647. This study reinforces the observation that mycobacteria can be detected in the workplace, especially where metal machining occurs, and that workers can develop granulomatous lung disease that mimics sarcoidosis by inhaling mycobateria- contaminated oil mists.
9. Perlman SE, Friedman S, Galea S, et al. Short-term and medium-term health effects of 9/11. Lancet 2011; 378:925-934. In this analysis of the health outcomes of individuals exposed to dust from the World Trade Center disaster, the researchers reported an increased rate of sarcoid-like disease in firefighters, in the first year after 9/11.
10. Jordan HT, Stellman SD, Prezant D, et al. Sarcoidosis diagnosed after September 11, 2001, among adults exposed to the World Trade Center disaster. J Occup Environ Med 2011; 53:966-974. This study stratified World Trade Center Health Registry participants who had physician-confirmed, biopsy-proven diagnoses of post-9/11 sarcoidosis by level of dust cloud exposure, as determined by questionnaire. The results suggest that more intensive rescue and recovery activities (and accompanying higher levels of exposure) are associated with increased risk for developing sarcoidosis.
11. Bowers B, Hasni S, Gruber BL. Sarcoidosis in World Trade Center rescue workers presenting with rheumatologic manifestations. J Clin Rheumatol 2010; 16:26-27.
12. Crowley LE, Herbert R, Moline JM, et al. 'Sarcoid like' granulomatous pulmonary disease in World Trade Center disaster responders. Am J Ind Med 2010 [cited 6 December 2011]. http://www.ncbi.nlm.nih.gov/pubmed/21181996. This study examined the health records and reported dust exposure levels for World Trade Center emergency responders and firefighters who reported 'sarcoid-like'disease. Importantly, this study reported a calculated annual incidence of 'sarcoidlike'disease of 229 cases per 100 000 person-years, significantly greater than what has been observed in other populations. It adds to the body of evidence that points to a role for inorganic particulate dust in promoting sarcoidosis-like illness.
13. Checchi L, Nucci MC, Gatti AM, et al. Sarcoidosis in a dental surgeon: a case report. J Med Case Rep 2010; 4:259-262.
14. Kawano-Dourado LB, Carvalho CRR, Santos UP, et al. Tunnel excavation triggering pulmonary sarcoidosis. Am J Ind Med. 2011 [cited 6 December 2011]. http://www.ncbi.nlm.nih.gov/pubmed/22113960.
15. Huizar I, Malur A, Midgette YA, et al. Novel murine model of chronic granulomatous lung inflammation elicited by carbon nanotubes. Am J Respir Cell Mol Biol 2011; 45:858-866. The authors present an interesting mouse model of granuloma formation in response to carbon nanotubes. As in other mouse models, the granulomas were more loosely formed than those seen in humans, but their formation and associated cytokine secretion appeared mechanistically similar to that seen in human disease. This article joins a mounting body of literature suggesting that nanotubes pose a potential risk to worker health.
16. Napierska D, Thomassen LCJ, Lison D. The nanosilica hazard: another variable entity. Part Fibre Toxicol 2010; 7:39-71.
17. Billi F, Campbell P. Nanotoxicology of metal wear particles in total joint arthroplasty: a review of current concepts. J Appl Biomater Biomech 2010; 8:1-6.
18. Song Y, Li X, Wang L, et al. Nanomaterials in humans: identification, characteristics, and potential damage. Toxicol Pathol 2011; 39:841-849. An important follow-up article to an earlier report of a group of women exposed to nanoparticles who developed pleural effusions, pulmonary inflammation, and granulomas. This article analyzed the tissue samples from women and describes the histologic changes as well as the chemical composition of the nanoparticles. The authors found silica nanoparticles in the granulomas, suggesting that it was the causative agent. The pathology of granulomas was more indicative of foreign-body granulomas, rather than the kind of robust hypersensitivity immune granulomas seen in sarcoidosis.
19. Ahn YS, Kim MG. Occupational Skin Diseases in Korea [Review]. J Korean Med Sci 2010; 25:S46-S52.
20. Bai YP,Wang TE,Wang ZX, Cao J, et al. Effect of Sympathetic Nerves on Proliferation of Splenic Lymphocytes and Antioxidant Function of Maternal Spleen in Early Pregnant Mice. Anat Rec 2011:.
21. Choi KS, Kang SK. Occupational Psychiatric Disorders in Korea [Review]. J Korean Med Sci 2010; 25:S87-S93.
22. Crawford LJA, Peake R, Price S, Morris TCM, et al. Adiponectin is produced by lymphocytes and is a negative regulator of granulopoiesis. J Leukoc Biol 2010; 88:807-811.
23. Crowley LE, Herbert R, Moline JM, et al. 'Sarcoid like'granulomatous pulmonary disease in World Trade Center disaster responders. Am J Ind Med 2010 [cited 6 December 2011]. http://www.ncbi.nlm.nih.gov/pubmed/21181996. [12]
24. Huizar I, Malur A, Midgette YA, et al. Novel murine model of chronic granulomatous lung inflammation elicited by carbon nanotubes. Am J Respir Cell Mol Biol 2011; 45:858-866. [15]
25. Iossifova YY, Cox-Ganser JM, Park J-H, et al. Lack of respiratory improvement following remediation of a water-damaged office building. Am J Ind Med 2011; 54:269-277. [03]
26. Jordan HT, Stellman SD, Prezant D, et al. Sarcoidosis diagnosed after September 11, 2001, among adults exposed to the World Trade Center disaster. J Occup Environ Med 2011; 53:966-974. [10]
27. Jurkowska H, Uchacz T, Roberts J, Wrobel M. Potential therapeutic advantage of ribose-cysteine in the inhibition of astrocytoma cell proliferation. Amino Acids 2011; 41:131-139.
28. Kang SK, Kim EA. Occupational Diseases in Korea [Review]. J Korean Med Sci 2010; 25:S4-S12.
29. Kim JE, Kim SH, Kim JH, Bahn JW, et al. A Case of Piperacillin-induced Occupational Anaphylaxis: Detection of Serum IgE to Piperacillin-HSA Conjugate. J Korean Med Sci 2011; 26:682-685.
30. Kim KS. Occupational Hearing Loss in Korea [Review]. J Korean Med Sci 2010; 25:S62-S69.
31. Laney AS, Cragin LA, Blevins LZ, et al. Sarcoidosis, asthma, and asthma-like symptoms among occupants of a historically water-damaged office building. Indoor Air 2009; 19:83-90. [02]
32. Oswald-Richter KA, Beachboard DC, Zhan X, et al. Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosis. Respir Res 2010; 11:161-172. [06]
33. Perlman SE, Friedman S, Galea S, et al. Short-term and medium-term health effects of 9/11. Lancet 2011; 378:925-934. [09]
34. Song Y, Li X, Wang L, et al. Nanomaterials in humans: identification, characteristics, and potential damage. Toxicol Pathol 2011; 39:841-849. [18]
35. Terčelj M, Stopinšek S, Ihan A, et al. In vitro and in vivo reactivity to fungal cell wall agents in sarcoidosis. Clin Exp Immunol 2011; 166:87-93. [05]
36. Tillie-Leblond I, Grenouillet F, Reboux G, et al. Hypersensitivity pneumonitis and metalworking fluids contaminated by mycobacteria. Eur Respir J 2011; 37:640-647. [08]
37. Walker B, Adenuga B, Mouton C. The Relevance of Occupational Medicine to Primary Care in the 21st Century. J Natl Med Assoc 2011; 103:306-312.
38. Yuki K, Soriano SG, Shimaoka M. Sedative Drug Modulates T-Cell and Lymphocyte Function-Associated Antigen-1 Function. Anesth Analg 2011; 112:830-838.