Del(13q14.3) length matters: An integrated analysis of genomic, fluorescence in situ hybridization and clinical data in 169 chronic lymphocytic leukaemia patients with 13q deletion alone or a normal karyotype

Hematological Oncology

Volumn 30, Issue 1, 2012, Pages 46-49

  Mian, Michael ^a,b   Rinaldi, Andrea ^a   Mensah, Afua Adjeiwaa ^a   Rossi, Davide ^c   Ladetto, Marco ^d   Forconi, Francesco ^e   Marasca, Roberto ^f   Gattei, Valter ^g   Zucca, Emanuele ^a   Cavalli, Franco ^a   Gaidano, Gianluca ^b   Kwee, Ivo ^a,h   Bertoni, Francesco ^a  

^a ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

^b Azienda Ospedaliera S Maurizio   (Italy)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

^e UNIVERSITY OF SIENA   (Italy)

^f UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^g CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^h DALLE MOLLE INSTITUTE FOR ARTIFICIAL INTELLIGENCE IDSIA   (Switzerland)

Author keywords

13q; Affymetrix; Chronic lymphocytic leukaemia; DLEU7; MIR15; Prognosis; RB1

Indexed keywords

GENOMIC DNA;

CHROMOSOME DELETION; CHROMOSOME DELETION 13Q; CHRONIC LYMPHATIC LEUKEMIA; COPY NUMBER VARIATION; DNA MICROARRAY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCUS; GENOME ANALYSIS; HETEROZYGOSITY; HUMAN; KARYOTYPE; LETTER; PRIORITY JOURNAL;

CHROMOSOME DELETION; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 13; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED;

EID: 84858149539     PISSN: 02780232     EISSN: 10991069     Source Type: Journal    
DOI: 10.1002/hon.997     Document Type: Letter

References (15)

1. Dighiero G, Hamblin TJ. Chronic lymphocytic leukaemia. Lancet 2008; 371: 1017-1029.
2. Gribben JG. How I treat CLL up front. Blood 2010; 115: 187-197.
3. Bulian P, Tarnani M, Rossi D, et al. Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia. Hematol Oncol 2010, Jul 28. [Epub ahead of print].
4. Klein U, Lia M, Crespo M, et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 2010; 17: 28-40.
5. Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002; 99: 15524-15529.
6. Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-1916.
7. Ouillette P, Erba H, Kujawski L, Kaminski M, Shedden K, Malek SN. Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14. Cancer Res 2008; 68: 1012-1021.
8. Palamarchuk A, Efanov A, Nazaryan N, et al. 13q14 deletions in CLL involve cooperating tumor suppressors. Blood 2010; 115: 3916-3922.
9. Mosca L, Fabris S, Lionetti M, et al. Integrative genomics analyses reveal molecularly distinct subgroups of B-cell chronic lymphocytic leukemia patients with 13q14 deletion. Clin Cancer Res 2010; 16: 5641-5653.
10. Parker H, Rose-Zerilli MJ, Parker A, et al. 13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia. Leukemia 2011; 25: 489-497.
11. Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) updating the National Cancer Institute-Working Group (NCI-WG) 1996 guidelines. Blood 2008; 111: 5446-5456.
12. Olshen AB, Venkatraman ES, Lucito R, Wigler M. Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics 2004; 5: 557-572.
13. Rinaldi A, Mian M, Kwee I, et al. SNP6 array better defines chronic lymphocytic leukemia (CLL) prognostic groups. ASH Annual Meeting Abstracts 2010; 116: 3611.
14. Van Dyke DL, Shanafelt TD, Call TG, et al. A comprehensive evaluation of the prognostic significance of 13q deletions in patients with B-chronic lymphocytic leukaemia. Br J Haematol 2010; 148: 544-550.
15. Hernandez JA, Rodriguez AE, Gonzalez M, et al. A high number of losses in 13q14 chromosome band is associated with a worse outcome and biological differences in patients with B-cell chronic lymphoid leukemia. Haematologica 2009; 94: 364-371.