Strategies for prevention of Clostridium difficile infection

Journal of Hospital Medicine

Volumn 7, Issue SUPPL. 3, 2012, Pages

  Dubberke, Erik ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CEPHALOSPORIN; CLINDAMYCIN; GATIFLOXACIN; MOXIFLOXACIN; VANCOMYCIN;

BACTERIUM CONTAMINATION; CLOSTRIDIUM DIFFICILE INFECTION; COMMUNITY ACQUIRED PNEUMONIA; DISEASE TRANSMISSION; ENVIRONMENTAL HEALTH; HEALTH CARE PERSONNEL; HOSPITAL INFECTION; HUMAN; HYGIENE; INFECTION CONTROL; INSTRUMENT STERILIZATION; MEDICAL STAFF; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR; STETHOSCOPE; THERMOMETER; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; DISINFECTION; GLOVES, PROTECTIVE; GUIDELINES AS TOPIC; HANDWASHING; HEALTH FACILITIES; HUMANS; INFECTION CONTROL; PATIENT ISOLATION; PERSONNEL, HOSPITAL;

EID: 84858116768     PISSN: 15535592     EISSN: 15535606     Source Type: Journal    
DOI: 10.1002/jhm.1908     Document Type: Review

References (24)

1. Riddle DJ, Dubberke ER. Clostridium difficile infection in the intensive care unit. Infect Dis Clin North Am. 2009; 23(3): 727-743.
2. Dubberke ER, Gerding DM, Classen D. Strategies to prevent Clostridium difficile infections in acute care hospitals. Infect Control Hosp Epidemiol. 2008; 29(suppl 1): S81-S92.
3. McFarland LV, Mulligan ME, Kwok RY, Stamm WE. Nosocomial acquisition of Clostridium difficile infection. N Engl J Med. 1989; 320(4): 204-210.
4. Clabots CR, Johnson S, Olson MM, et al. Acquisition of Clostridium difficile by hospitalized patients: evidence for colonized new admissions as a source of infection. J Infect Dis. 1992; 166: 561-567.
5. Chang VT, Nelson K. The role of physical proximity in nosocomial diarrhea. Clin Infect Dis. 2000; 31(3): 717-722.
6. Shaughnessy MK, Micielli RL, DePestel DD, et al. Evaluation of hospital room assignment and acquisition of Clostridium difficile infection. Infect Control Hosp Epidemiol. 2011; 32(3): 201-206.
7. Zafar AB, Gaydos LA, Furlong WB, Nguyen MH, Mennonna PA. Effectiveness of infection control program in controlling nosocomial Clostridium difficile. Am J Infect Control. 1998; 26(6): 588-593.
8. Muto CA, Blank MK, Marsh JW, et al. Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach. Clin Infect Dis. 2007; 45(10): 1266-1273.
9. Johnson S, Samore MH, Farrow KA, et al. Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals. N Engl J Med. 1999; 341(22): 1645-1651.
10. Oughton MT, Loo VG, Dendukuri N, Fenn S, Libman MD. Hand hygiene with soap and water is superior to alcohol rub and antiseptic wipes for removal of Clostridium difficile. Infect Control Hosp Epidemiol. 2009; 30(10): 939-944.
11. Gerding DM, Muto CA, Owens RC. Measures to control and prevent Clostridium difficile infection. Clin Infect Dis. 2008; 46(suppl 1): S43-S49.
12. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol. 2010; 31(5): 431-455.
13. Merrigan M, Venugopal A, Mallozzi M, et al. Human hypervirulent Clostridium difficile strains exhibit increased sporulation as well as robust toxin production. J Bacteriol. 2010; 192(19): 4904-4911.
14. Valiquette L, Cossette B, Garant MP, Diab H, Pépin J. Impact of a reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain. Clin Infect Dis. 2007; 45(suppl 2): S112-S121.
15. Pépin J, Saheb N, Coulombe MA, et al. Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec, Canada. Clin Infect Dis. 2005; 41(9): 1254-1260.
16. Loo VG, Poirier L, Miller MA, Oughton M, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med. 2005; 353: 2442-2449.
17. Climo MW, Israel DS, Wong ES, et al. Hospital-wide restriction of clindamycin: effect on the incidence of Clostridium difficile-associated diarrhea and cost. Ann Intern Med. 1998; 128: 989-995.
18. Davey P, Brown E, Fenelon L, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2005CD003543.
19. Khan R, Cheesbrough J. Impact of changes in antibiotic policy on Clostridium difficile-associated diarrhoea (CDAD) over a five-year period in a district general hospital. J Hosp Infect. 2003; 54: 104-108.
20. O'Connor KA, Kingston M, O'Donovan M, et al. Antibiotic prescribing policy and Clostridium difficile diarrhoea. Q J Med. 2004; 97: 423-429.
21. Association for Professionals in Infection Control and Epidemiology (APIC). Guide to the elimination of Clostridium difficile in healthcare settings. Available at: Accessed August 9, 2011.
22. Centers for Disease Control and Prevention. Frequently asked questions about Clostridium difficile for healthcare providers. Available at: Accessed August 9, 2011.
23. Centers for Disease Control and Prevention. Information about the current strain of Clostridium difficile. Available at: Accessed June 15, 2011.
24. Institute for Healthcare Improvement. Available at: Accessed July 26, 2011.