Normal uptake of 68Ga-DOTA-TOC by the pancreas uncinate process mimicking malignancy at somatostatin receptor PET

Clinical Nuclear Medicine

Volumn 37, Issue 4, 2012, Pages 362-365

  Jacobsson, Hans ^a   Larsson, Patricia ^a   Jonsson, Cathrine ^a   Jussing, Emma ^a   Grybäck, Per ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

68Ga DOTA TOC; false positive; pancreas uncinate process; PET; somatostatin receptor scintigraphy

Indexed keywords

GALLIUM 68; PENTETREOTIDE IN 111; SOMATOSTATIN RECEPTOR; TETRAXETAN; DRUG DERIVATIVE; GA(III) DOTATOC; GA(III)-DOTATOC; OCTREOTIDE; ORGANOMETALLIC COMPOUND;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG UPTAKE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PANCREAS; PANCREAS CANCER; RETROSPECTIVE STUDY; TUMOR VOLUME; CONGENITAL MALFORMATION; DIFFERENTIAL DIAGNOSIS; METABOLISM; MIDDLE AGED; PANCREAS TUMOR; SCINTISCANNING; TRANSPORT AT THE CELLULAR LEVEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL TRANSPORT; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; OCTREOTIDE; ORGANOMETALLIC COMPOUNDS; PANCREAS; PANCREATIC NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; RECEPTORS, SOMATOSTATIN; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84858114170     PISSN: 03639762     EISSN: 15360229     Source Type: Journal    
DOI: 10.1097/RLU.0b013e3182485110     Document Type: Article

References (20)

1. Reubi JC, Maurer R, Werder KV, et al. Somatostatin receptors in human endocrine tumors. Cancer Res. 1987;47:551-585.
2. Reubi JC, Kvols L, Krenning E, et al. Distribution of somatostatin receptors in normal and tumor tissue. Metab Clin Exp. 1990;39(suppl 2):78-81. (Pubitemid 20286341)
3. Brazeau P, Vale W, Burgus R, et al. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science. 1973; 179:77-79.
4. Reubi JC. New specific radioligand for one subpopulation of brain somatostatin receptors. Life Sci. 1985;36:1829-1836. (Pubitemid 15081162)
5. Krenning EP, Kwekkeboom DJ, Bakker WH, et al. Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1]-and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients. Eur J Nucl Med. 1993;20: 716-731. (Pubitemid 23284773)
6. Stolz B, Smith-Jones PM, Albert R, et al. Biological characterisation of [67Ga] or [68Ga] labelled DFO-octreotide (SDZ 216-927) for PET studies of somatostatin receptor positive tumors. Horm Metab Res. 1994;26:453-459.
7. Hofmann M, Maecke H, Börner AR, et al. Biokinetics and imaging with the somatostatin receptor PET radioligand 68Ga-DOTATOC: preliminary data. Eur J Nucl Med. 2001;28:1751-1757.
8. Kowalski J, Henze M, Schuhmacher J, et al. Evaluation of positron tomography imaging using [68Ga]-DOTA-D Phe1-Tyr3-Octreotide in comparison to [111In]-DTPAOC SPECT. First results in patients with neuroendocrine tumors. Mol Imaging Biol. 2003;5:42-48. (Pubitemid 36596544)
9. Gabriel M, Decristoforo C, Kendler D, et al. 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med. 2007;48:508-518. (Pubitemid 47571404)
10. Buchmann I, Henze M, Engelbrecht S, et al. Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2007;34:1617-1626. (Pubitemid 47476920)
11. Velikyan I, Långström B, Beyer G; Method of obtaining gallium-68 and use thereof and device for carrying out said method. UK patent. WO 2004/ 089517.
12. Velikyan I, Långström B; Microwave method for preparing radiolabelled gallium complexes. UK patent. WO 2004/089425.
13. OSullivan AW, Heaton N, Rela M. Cancer of the uncinate process of the pancreas: surgical anatomy and clinicopathological features. Hepatobiliary Pancreat Dis Int. 2009;8:569-574.
14. Bunning J, Merchant SH, Crooks LA, et al. Indium-111 pentetreotide uptake by pancreatic polypeptide cell hyperplasia. Pancreas. 2007;35:372-375.
15. Prasad V, Baum RP. Biodistribution of the Ga-68 labeled somatostatin analogue DOTA-NOC in patients with neuroendocrine tumors: characterization of uptake in normal organs and tumor lesions. Q J Nucl Med Mol Imaging. 2010;54:61-67.
16. Orci L, Baetens D, Ravazzola M, et al. Pancreatic polypeptide and glucagon: non-random distribution in pancreatic islets. Life Sci. 1976;19: 1811-1816.
17. Orci L, Stefan Y, Malaisse-Lagae F, et al. Instability of the pancreatic endocrine cell populations throughout life. Lancet. 1979;i:615-616. (Pubitemid 9136410)
18. Portela-Gomes GM, Grimelius L, Westermark P, et al. Somatostatin receptor subtypes in human type 2 diabetic islets. Pancreas. 2010;39:836-842.
19. Malaisse-Lagae F, Stefan Y, Cox J, et al. Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide. Diabetologia. 1979;17:361-365. (Pubitemid 10219168)
20. Portela-Gomes GM, Stridsberg M, Grimelius L, et al. Expression of the five different somatostatin receptor subtypes in endocrine cells of the pancreas. Appl Immunohistochem Mol Morphol. 2000;8:126-132. (Pubitemid 30609973)