Gene expression patterns of the 11β-hydroxysteroid dehydrogenase 2 enzyme in human placenta from intrauterine growth restriction: The role of impaired feto-maternal glucocorticoid metabolism

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 161, Issue 1, 2012, Pages 12-17

  Börzsönyi, Balázs ^a   Demendi, Csaba ^a   Pajor, Attila ^a   Rigó, János ^b   Marosi, Krisztina ^c   Ágota, Annamária ^c   Nagy, Zsolt B ^c   Joó, József Gábor ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c NAGY GÉN Diagnostics and Reasearch Ltd   (Hungary)

Author keywords

11 Hydroxysteroid dehydrogenase 2; Gene expression; Intrauterine growth restriction; Placenta; Threatened intrauterine asphyxia

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; BETA ACTIN; GLUCOCORTICOID;

ADULT; ARTICLE; BIRTH WEIGHT; BLOOD PLACENTA BARRIER; BODY MASS; CARDIOVASCULAR RISK; CESAREAN SECTION; CLINICAL FEATURE; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; FETUS; FETUS HYPOXIA; FETUS WEIGHT; GENE EXPRESSION; GESTATIONAL AGE; HUMAN; INTRAUTERINE GROWTH RETARDATION; MAJOR CLINICAL STUDY; MALE; MATERNAL NUTRITION; METABOLIC DISORDER; NEWBORN; NUCLEOTIDE SEQUENCE; PLACENTA; PRIORITY JOURNAL; SEX DIFFERENCE; VAGINAL DELIVERY; WEIGHT GAIN;

EID: 84858081134     PISSN: 03012115     EISSN: 18727654     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2011.12.013     Document Type: Article

References (27)

1. H.A. Wollmann Intrauterine growth restriction: definition and etiology Horm Res 49 Suppl. 2 1988 1 6
2. S. Sheikh, P. Satoskar, and D. Bhartiya Expression of insulin-like growth factor-I and placental growth hormone mRNA in placentae: a comparison between normal and intrauterine growth retardation pregnancies Mol Hum Reprod 7 2001 287 292 (Pubitemid 32208515)
3. P.D. Gluckman, and J.E. Harding The physiology and pathophysiology of intrauterine growth retardation Horm Res 48 Suppl. 1 1997 11 16 (Pubitemid 27199177)
4. D.J. Barker The fetal origins of hypertension J Hypertens Suppl 14 1996 S117 S120
5. J.R. Seckl, R. Benediktsson, and R.S. Lindsay Placental 11 beta-hydroxysteroid dehydrogenase and the programming of hypertension J Steroid Biochem Mol Biol 55 1995 447 455 (Pubitemid 26022378)
6. R. Benediktsson, A.A. Calder, and C.R. Edwards Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure Clin Endocrinol (Oxf) 46 1997 161 166 (Pubitemid 27122161)
7. P.M. Stewart, and Z.S. Krozowski 11 beta-Hydroxysteroid dehydrogenase Vitam Horm 57 1999 249 324
8. K. Sun, K. Yang, and J.R. Challis Differential expression of 11 beta-hydroxysteroid dehydrogenase types 1 and 2 in human placenta and fetal membranes J Clin Endocrinol Metab 82 1997 300 305 (Pubitemid 27021315)
9. J.F. Johnstone, A.D. Bocking, E. Unlugedik, and J.R. Challis The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta J Soc Gynecol Investig 12 2005 238 245 (Pubitemid 40615092)
10. I. Bujalska, M. Shimojo, A. Howie, and P.M. Stewart Human 11 beta-hydroxysteroid dehydrogenase: studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue Steroids 62 1997 77 82 (Pubitemid 27066989)
11. R. Wächter, L. Masarik, and M. Bürzle Differential expression and activity of 11beta-hydroxysteroid dehydrogenase in human placenta and fetal membranes from pregnancies with intrauterine growth restriction Fetal Diagn Ther 25 2009 328 335
12. A. Tzschoppe, E. Struwe, and H. Blessing Placental 11beta-HSD2 gene expression at birth is inversely correlated with growth velocity in the first year of life after intrauterine growth restriction Pediatr Res 65 2009 647 653
13. L. Myatt, and K. Sun Role of fetal membranes in signaling of fetal maturation and parturition Int J Dev Biol 54 2010 545 553
14. E. Struwe, G.M. Berzl, and R.L. Schild Simultaneously reduced gene expression of cortisol-activating and cortisol-inactivating enzymes in placentas of small-for-gestational-age neonates Am J Obstet Gynecol 197 43 2007 e1 e6
15. E. Schoof, M. Girstl, and W. Frobenius Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression during human gestation Eur J Endocrinol 145 2001 187 192 (Pubitemid 32707605)
16. J.R. Challis, D. Sloboda, and S.G. Matthews The fetal placental hypothalamic-pituitary-adrenal (HPA) axis, parturition and post natal health Mol Cell Endocrinol 185 2001 135 144 (Pubitemid 33103962)
17. J.M. Reinisch, N.G. Simon, W.G. Karow, and R. Gandelman Prenatal exposure to prednisone in humans and animals retards intrauterine growth Science 202 1978 436 438 (Pubitemid 9051835)
18. R.M. Ward Pharmacologic enhancement of fetal lung maturation Clin Perinatol 21 1994 523 542 (Pubitemid 24284508)
19. J.S. Fuqua Growth after organ transplantation Semin Pediatr Surg 15 2006 162 169 (Pubitemid 43963386)
20. J.J. Lee Birth weight for gestational age patterns by sex, plurality and parity in Korean populations Korean J Perinatol 18 2007 1 11
21. H.L. Mi, J.J. Yeo, and M.L. Sang Placental gene expression is related to glucose metabolism and fetal cord blood levels of insulin and insulin-like growth factors in intrauterine growth restriction Early Hum Dev 86 2010 45 50
22. C.L. McTernan, N. Draper, and H. Nicholson Reduced placental 11beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms J Clin Endocrinol Metab 86 2001 4979 4983 (Pubitemid 33020553)
23. J. Dy, H. Guan, R. Sampath-Kumar, B.S. Richardson, and K. Yang Placental 11beta-hydroxysteroid dehydrogenase type 2 is reduced in pregnancies complicated with idiopathic intrauterine growth Restriction: evidence that this is associated with an attenuated ratio of cortisone to cortisol in the umbilical artery Placenta 29 2008 193 200 (Pubitemid 351174354)
24. T. Ulinski, and P. Cochat Longitudinal growth in children following kidney transplantation: from conservative to pharmacological strategies Pediatr Nephrol 21 2006 903 909 (Pubitemid 43885087)
25. V. Mericq, P. Medina, and E. Kakarieka Differences in expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birthweight and gender Eur J Endocrinol 161 2009 419 425
26. M.J. Stark, I.M. Wright, and V.L. Clifton Sex-specific alterations in placental 11beta-hydroxysteroid dehydrogenase 2 activity and early postnatal clinical course following antenatal betamethasone Am J Physiol Regul Integr Comp Physiol 297 2009 R510 R514
27. A. Homan, H. Guan, and D.B. Hardy Hypoxia blocks 11β-hydroxysteroid dehydrogenase type 2 induction in human trophoblast cells during differentiation by a time-dependent mechanism that involves both translation and transcription Placenta 27 2006 832 840 (Pubitemid 44201636)