DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4)

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Quentmeier, Hilmar ^a   Eberth, Sonja ^a,b   Romani, Julia ^a   Weich, Herbert A ^c   Zaborski, Margarete ^a   Drexler, Hans G ^a  

^a German Collection of Microorganisms and Cell Cultures ^*  (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DNA SEQUENCE; ENZYME ACTIVATION; FLOW CYTOMETRY; FLT4 GENE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SILENCING; GENETIC REGULATION; HUMAN; HUMAN CELL; KDR GENE; LEUKEMIA CELL LINE; LYMPHOMA CELL LINE; MICROVASCULAR ENDOTHELIAL CELL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE, TUMOR; DNA METHYLATION; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LEUKEMIA; LYMPHOMA; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 84858072273     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-19     Document Type: Article

References (30)

1. Larrivée B, Karsan A. Signaling pathways induced by vascular endothelial growth factor (review). Int J Mol Med 2000, 5:447-456.
2. Guo S, Colbert LS, Fuller M, Zhang Y, Gonzalez-Perez RR. Vascular endothelial growth factor receptor-2 in breast cancer. Biochim Biophys Acta 2010, 1806:108-121. 2885515, 20462514.
3. de Jong JS, van Diest PV, van der Valk P, Baak JPA. Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: an inventory in search of autocrine and paracrine loops. J Pathol 1998, 184:44-52. 10.1002/(SICI)1096-9896(199801)184:1<44::AID-PATH984>3.0.CO;2-H, 9582526.
4. Boocock CA, Charnock-Jones DS, Sharkey AM, McLaren J, Barker PJ, Wright KA, Twentyman PR, Smith SK. Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Nat Cancer Inst 1995, 87:506-516. 10.1093/jnci/87.7.506, 7707437.
5. Ferrer FA, Miller LJ, Lindquist R, Kowalczyk P, Laudone VP, Albertsen PC, Kreutzer DL. Expression of vascular endothelial growth factor receptors in human prostate cancer. Urology 1999, 54:567-572. 10.1016/S0090-4295(99)00156-9, 10475375.
6. Takahama M, Tsutsumi M, Tsujiuchi T, Kido A, Sakitani H, Iki K, Taniguchi S, Kitamura S, Konishi Y. Expression of vascular endothelial growth factor and its receptors during lung carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine in rats. Mol Carcinogenesis 1999, 24:287-293.
7. Dias S, Hattori K, Zhu Z, Heissig B, Choy M, Lane W, Wu Y, Chadburn A, Hyjek E, Gill M, Hicklin DJ, Witte L, Moore MAS, Rafii S. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J Clin Invest 2000, 106:511-521. 10.1172/JCI8978, 380247, 10953026.
8. Pazgal I, Boycov O, Shpilberg O, Okon E, Bairey O. Expression of VEGF-C, VEGF-D and their receptor VEGFR-3 in diffuse large B-cell lymphomas. Leuk Lymph 2007, 48:2213-2220.
9. Kivivuori SM, Siitonen S, Porkka K, Vettenranta K, Alitalo R, Saarinen-Pihkala U. Expression of vascular endothelial growth factor receptor 3 and Tie1 tyrosine kinase receptor on acute leukemia cells. Pediatr Blood Cancer 2007, 48:387-392. 10.1002/pbc.20857, 16685739.
10. Fielder W, Graeven U, Ergün S, Verago S, Kilic N, Stockschläder M, Hossfeld DK. Expression of FLT4 and its ligand VEGF-C in acute myeloid leukemia. Leukemia 1997, 11:1234-1237. 10.1038/sj.leu.2400722, 9264375.
11. Joergensen JM, Soerensen FB, Bendix K, Nielsen JL, Funder A, Karkkainen MJ, Tainola T, Soerensen AB, Pedersen FS, D'Amore F. Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas. Leuk Lymph 2009, 50:1647-1660.
12. Dias S, Choy M, Alitalo K, Rafii S. Vascular endothelial factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood 2002, 99:2179-2184. 10.1182/blood.V99.6.2179, 11877295.
13. Flister MJ, Wilber A, Hall KL, Iwata C, Miyazono K, Nisato RE, Pepper MS, Zawieja DC, Ran S. Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-κB and Prox1. Blood 2010, 115:418-429. 10.1182/blood-2008-12-196840, 2808162, 19901262.
14. Kim JY, Hwang JH, Zhou W, Shin J, Noh SM, Song IS, Kim JY, Lee SH, Kim J. The expression of VEGF receptor genes is concurrently influenced by epigenetic gene silencing of the genes and VDGF activation. Epigenetics 2009, 4:313-321. 10.4161/epi.4.5.9160, 19633424.
15. Kiec-Wilk B, Razny U, Mathers JC, Dembinska-Kiec A. DNA methylation, induced by beta-carotene and arachidonic acid, plays a regulatory role in the pro-angiogenic VEGF-receptor (KDR) gene expression in endothelial cells. J Physiol Pharmacol 2009, 60:49-53.
16. Drexler HG. Guide to Leukemia-Lymphoma Cell Lines 2010, Braunschweig, 2.
17. Quentmeier H, Schneider B, Röhrs S, Romani J, Zaborski M, MacLeod RAF, Drexler HG. SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines. J Hematol Oncol 2009, 2:3. 10.1186/1756-8722-2-3, 2636835, 19166587.
18. Dias S, Hattori K, Heissig B, Zhu Z, Wu Y, Witte L, Hicklin DJ, Tateno M, Bohlen P, Moore MAS, Rafii S. Inhibition of both paracrine and autocrine VEGF/VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias. Proc Natl Acad Sci USA 2001, 98:10857-10862. 10.1073/pnas.191117498, 58564, 11553814.
19. Bellamy WT, Richter L, Sirjani D, Roxas C, Glinsmann-Gibson B, Frutiger Y, Grogan TM, List AF. Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes. Blood 2001, 97:1427-1434. 10.1182/blood.V97.5.1427, 11222390.
20. Drexler HG, Zaborski M, Quentmeier H. Cytokine response profiles of human myeloid factor-dependent leukemia cell lines. Leukemia 1997, 11:701-708. 10.1038/sj.leu.2400633, 9180295.
21. Salameh A, Glavagni F, Bardelli M, Bussolino F, Oliviero S. Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways. Blood 2005, 106:3423-3431. 10.1182/blood-2005-04-1388, 16076871.
22. Chien MH, Ku CC, Johansson G, Chen MW, Hsiao M, Su JL, Inoue H, Hua KT, Wei LH, Kuo ML. Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis 2009, 30:2005-2013. 10.1093/carcin/bgp244, 19825968.
23. Santos-Rosa H, Caldas C. Chromatin modifier enzymes, the histone code and cancer. Eur J Cancer 2005, 41:2381-2402. 10.1016/j.ejca.2005.08.010, 16226460.
24. Kerppola TK. Polycomb group complexes-many combinations, many functions. Trend Cell Biol 2009, 19:692-704.
25. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003, 349:2042-2054. 10.1056/NEJMra023075, 14627790.
26. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002, 16:6-21. 10.1101/gad.947102, 11782440.
27. Patterson C, Perrella MA, Hsieh CM, Yoshizumi M, Lee ME, Haber E. Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J Biol Chem 1995, 39:23111-23118.
28. Morr M, Takeuchi O, Akira S, Simon MM, Mühlradt PF. Differential recognition of structural details of bacterial lipopeptides by toll-like receptors. Eur J Immunol 2002, 32:3337-3347.
29. Sacht G, Märten A, Deiters U, Süßmuth R, Jung G, Wingender E, Mühlradt PF. Activation of nuclear factor-κB in macrophages by mycoplasmal lipopeptides. Eur J Immunol 1998, 28:4207-4212. 10.1002/(SICI)1521-4141(199812)28:12<4207::AID-IMMU4207>3.0.CO;2-R, 9862357.
30. Kaufmann A, Mühlradt PF, Gemsa D, Sprengler H. Induction of cytokines and chemokines in human monocytes by Mycoplasma fermentans-derived lipoprotein MALP-2. Infect Immun 1999, 67:6303-6308. 97033, 10569741.