Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation

BMC Veterinary Research

Volumn 8, Issue , 2012, Pages

  Schlegel, Gloria ^a   Keller, Janine ^a   Hirche, Frank ^b   Geißler, Stefanie ^b   Schwarz, Frieder J ^c   Ringseis, Robert ^a   Stangl, Gabriele I ^b   Eder, Klaus ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BOS; RODENTIA; SUIDAE;

4 N TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE; 4-N-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CARNITINE; GAMMA BUTYROBETAINE DIOXYGENASE; MESSENGER RNA; ORGANIC CATION TRANSPORTER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; BLOOD; CATTLE; CHEMISTRY; EATING; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; LACTATION; LIVER; METABOLISM; MILK; PHYSIOLOGY; PREGNANCY; REAL TIME POLYMERASE CHAIN REACTION; REGRESSION ANALYSIS;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; CARNITINE; CATTLE; EATING; FEMALE; GAMMA-BUTYROBETAINE DIOXYGENASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LACTATION; LIVER; MILK; ORGANIC CATION TRANSPORT PROTEINS; PPAR ALPHA; PREGNANCY; REAL-TIME POLYMERASE CHAIN REACTION; REGRESSION ANALYSIS; RNA, MESSENGER;

EID: 84858059373     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-8-28     Document Type: Article

References (45)

1. McGarry JD, Brown NF. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem 1997, 244:1-14. 10.1111/j.1432-1033.1997.00001.x, 9063439.
2. Vaz FM, Wanders RJ. Carnitine biosynthesis in mammals. Biochem J 2002, 361:417-429. 10.1042/0264-6021:3610417, 1222323, 11802770.
3. Lahjouji K, Mitchell GA, Qureshi IA. Carnitine transport by organic cation transporters and systemic carnitine deficiency. Mol Genet Metab 2001, 73:287-297. 10.1006/mgme.2001.3207, 11509010.
4. Tein I. Carnitine transport: Pathophysiology and metabolism of known defects. J Inherit Metab Dis 2003, 26:147-169. 10.1023/A:1024481016187, 12889657.
5. Mandard S, Müller M, Kersten S. Peroxisome proliferator receptor α target genes. Cell Mol Life Sci 2004, 61:393-416. 10.1007/s00018-003-3216-3, 14999402.
6. Luci S, Geissler S, König B, Koch A, Stangl GI, Hirche F, Eder K. PPARα agonists up-regulate organic cation transporters in rat liver cells. Biochem Biophys Res Commun 2006, 350:704-708. 10.1016/j.bbrc.2006.09.099, 17011512.
7. van Vlies N, Ferdinandusse S, Turkenburg M, Wanders RJ, Vaz FM. PPARα-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation. Biochim Biophys Acta 2007, 1767:1134-1142. 10.1016/j.bbabio.2007.07.001, 17692817.
8. Koch A, König B, Stangl GI, Eder K. PPARα mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis. Exp Biol Med 2008, 233:356-365.
9. Ringseis R, Luci S, Spielmann J, Kluge H, Fischer M, Geissler S, Wen G, Hirche F, Eder K. Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species. Eur J Pharmacol 2008, 583:11-17. 10.1016/j.ejphar.2008.01.008, 18258227.
10. Maeda T, Wakasawa T, Funabashi M, Fukushi A, Fujita M, Motojima K, Tamai I. Regulation of Octn2 transporter (SLC22A5) by peroxisome proliferator activated receptor alpha. Biol Pharm Bull 2008, 31:1230-1236. 10.1248/bpb.31.1230, 18520060.
11. Bell AW. Lipid metabolism in liver and selected tissues and in the whole body of ruminant animals. Prog Lipid Res 1980, 18:117-164.
12. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J Clin Invest 1999, 103:1489-1498. 10.1172/JCI6223, 408372, 10359558.
13. Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor α in the cellular fasting response; the PPARα-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 1999, 96:7473-7478. 10.1073/pnas.96.13.7473, 22110, 10377439.
14. Litherland NB, Bionaz M, Wallace RL, Loor JJ, Drackley JK. Effects of the peroxisome proliferator-activated receptor-alpha agonists clofibrate and fish oil on hepatic fatty acid metabolism in weaned dairy calves. J Dairy Sci 2010, 93:2404-2418. 10.3168/jds.2009-2716, 20494149.
15. Bionaz M, Thering BJ, Loor JJ. Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-α activation. Br J Nutr 2012, 107:179-191. 10.1017/S0007114511002777, 21729373.
16. Loor JJ, Dann HM, Everts RE, Oliveira R, Green CA, Janovick Guretzky NA, Rodriguez-Zas SL, Lewin HA, Drackley JK. Temporal gene expression profiling of liver from periparturient dairy cows reveals complex adaptive mechanisms in hepatic function. Physiol Genomics 2005, 23:217-226. 10.1152/physiolgenomics.00132.2005, 16091418.
17. Loor JJ, Everts RE, Bionaz M, Dann HM, Morin DE, Oliveira R, Rodriguez-Zas SL, Drackley JK, Lewin HA. Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows. Physiol Genomics 2007, 32:105-116. 10.1152/physiolgenomics.00188.2007, 17925483.
18. Grum DE, Drackley JK, Younker RS, LaCount DW, Veenhuizen JJ. Nutrition during the dry period and hepatic lipid metabolism of periparturient dairy cows. J Dairy Sci 1996, 79:1850-1864. 10.3168/jds.S0022-0302(96)76553-0, 8923256.
19. Carlson DB, McFadden JW, D'Angelo A, Woodworth JC, Drackley JK. Dietary L-carnitine affects periparturient nutrient metabolism and lactation in multiparous cows. J Dairy Sci 2007, 90:3422-3441. 10.3168/jds.2006-811, 17582127.
20. Naumann K, Basler R, Seibold R, Barth C. Die chemische Untersuchung von Futtermitteln 2000, VDLUFA-Press, Darmstadt, Germany: Methodenbuch Bd. III. Verband Deutscher Landwirtschaftlicher Untersuchungs- und Forschungsanstalten.
21. German Society of Nutrition Physiology (GfE) Recommendations for the supply of energy and nutrients to dairy cows and growing cattle 1995, DLG-Verlag, Frankfurt/Main, Germany, German Society of Nutrition Physiology (GfE).
22. Hara A, Radin NS. Lipid extraction of tissues with a low toxicity solvent. Anal Biochem 1978, 90:420-426. 10.1016/0003-2697(78)90046-5, 727482.
23. De Hoff JL, Davidson LM, Kritchevsky D. An enzymatic assay for determining free and total cholesterol in tissue. Clin Chem 1978, 24:433-435.
24. Johnson DW. An acid hydrolysis method for quantification of plasma free and total carnitine by flow injection tandem mass spectrometry. Clin Biochem 2010, 43:1362-1367. 10.1016/j.clinbiochem.2010.08.015, 20727870.
25. Hirche F, Fischer M, Keller J, Eder K. Determination of carnitine, its short chain acyl esters and metabolic precursors trimethyllysine and γ-butyrobetaine by quasi-solid phase extraction and MS/MS detection. J Chromatogr B 2009, 877:2158-2162.
26. Von Ahlfen S, Schlumpberger M. Effects of low A260/A230 ratios in RNA preparations on downstream applications. QIAGEN Gene Expression Newsletter 2010, 15:6-7.
27. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002, 3:research0034-research0034.11. 126239, 12184808.
28. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using realtime quantitative PCR and the 2-ΔΔCt method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.
29. Janovick Guretzky NA, Carlson DB, Garrett JE, Drackley JK. Lipid metabolite profiles and milk production for Holstein and Jersey cows fed rumen-protected choline during the periparturient period. J Dairy Sci 2006, 89:188-200. 10.3168/jds.S0022-0302(06)72083-5, 16357282.
30. Ringseis R, Wege N, Wen G, Rauer C, Hirche F, Kluge H, Eder K. Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species. J Nutr Biochem 2009, 20:840-847. 10.1016/j.jnutbio.2008.07.012, 18926685.
31. Palin MF, Petit HV. Effects of polyunsaturated fatty acids on hepatic PPARα mRNA levels in the transition cow. J Anim Feed Sci Polish Acad Sci 2004, 13(Suppl 1):445-448.
32. Carriquiry M, Weber WJ, Fahrenkrug SC, Crooker BA. Hepatic gene expression in multiparous Holstein cows treated with bovine somatotropin and fed n-3 fatty acids in early lactation. J Dairy Sci 2009, 92:4889-4900. 10.3168/jds.2008-1676, 19762804.
33. Wen G, Ringseis R, Eder K. Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor α via a PPRE located in the first intron. Biochem Pharmacol 2010, 79:768-776. 10.1016/j.bcp.2009.10.002, 19819229.
34. Wen G, Kühne H, Rauer C, Ringseis R, Eder K. Mouse γ-butyrobetaine dioxygenase is regulated by peroxisome proliferator-activated receptor α through a PPRE located in the proximal promoter. Biochem Pharmacol 2011, 82:175-183. 10.1016/j.bcp.2011.04.006, 21549104.
35. Wen G, Ringseis R, Rauer C, Eder K. The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor α. Biochim Biophys Acta
36. Luci S, Hirche F, Eder K. Fasting and caloric restriction increases mRNA concentrations of novel organic cation transporter-2 and carnitine concentrations in rat tissues. Ann Nutr Metab 2008, 52:58-67. 10.1159/000118872, 18309235.
37. Ringseis R, Luci S, Spielmann J, Kluge H, Fischer M, Geissler S, Wen G, Hirche F, Eder K. Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species. Eur J Pharmcol 2008, 583:11-17.
38. Carlson DB, Woodworth JC, Drackley JK. Effect of L-carnitine infusion and feed restriction on carnitine status in lactating Holstein cows. J Dairy Sci 2007, 90:2367-2376. 10.3168/jds.2006-605, 17430940.
39. Ling B, Alcorn J. Acute administration of cefepime lowers L-carnitine concentrations in early lactation stage rat milk. J Nutr 2008, 138:1317-1322.
40. Katoh N. Relevance of apolipoproteins in the development of fatty liver and fatty liver-related peripartum diseases in dairy cows. J Vet Med Sci 2002, 64:293-307. 10.1292/jvms.64.293, 12014573.
41. Carlson DB, Litherland NB, Dann HM, Woodworth JC, Drackley JK. Metabolic effects of abomasal L-carnitine infusion and feed restriction in lactating Holstein cows. J Dairy Sci 2006, 89:4819-4834. 10.3168/jds.S0022-0302(06)72531-0, 17106113.
42. Dann HM, Drackley JK. Carnitine palmitoyltransferase I in liver of periparturient dairy cows: effects of prepartum intake, postpartum induction of ketosis, and periparturient disorders. J Dairy Sci 2005, 88:3851-3859. 10.3168/jds.S0022-0302(05)73070-8, 16230690.
43. Litherland NB, Dann HM, Drackley JK. Prepartum nutrient intake alters palmitate metabolism by liver slices from peripartal dairy cows. J Dairy Sci 2011, 94:1928-1940. 10.3168/jds.2010-3220, 21426984.
44. Jesse BW, Emery RS, Thomas JW. Control of bovine hepatic fatty acid oxidation. J Dairy Sci 1986, 69:2290-2297. 10.3168/jds.S0022-0302(86)80667-1, 3782585.
45. Drackley JK, Beitz DC, Young JW. Regulation of in vitro metabolism of palmitate by carnitine and propionate in liver from dairy cows. J Dairy Sci 1991, 74:3014-3024. 10.3168/jds.S0022-0302(91)78487-7, 1779055.