Thrombomodulin and the brain: Past, present, and future

Neurology

Volumn 78, Issue 3, 2012, Pages 157-158

  Fisher, Mark ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5A; BLOOD CLOTTING FACTOR 7A; RECOMBINANT THROMBOMODULIN; THROMBIN; THROMBOMODULIN; TISSUE FACTOR PATHWAY INHIBITOR;

ANTICOAGULATION; ARTERIOLE; ARTERY DIAMETER; BRAIN ARTERY; CADASIL; CEREBROVASCULAR DISEASE; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG MECHANISM; EDITORIAL; HUMAN; IMMUNOHISTOCHEMISTRY; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROKE; VASCULAR PATENCY; AGING; FEMALE; MALE; METABOLISM; NOTE; PATHOLOGY; VASCULAR ENDOTHELIUM;

AGING; CEREBRAL SMALL VESSEL DISEASES; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; THROMBOMODULIN;

EID: 84858058124     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3182447e65     Document Type: Editorial

References (10)

1. Giwa MO, Williams J, Elderfield K, et al. Neuropathologic evidence of endothelial changes in cerebral small vessel disease. Neurology 2012;78:167-174.
2. Ito T, Maruyama I. Thrombomodulin: protectorate God of the vasculature in thrombosis and inflammation. J Thromb Haem 2011;9(suppl 1):168-173.
3. Ishii H, Salem HH, Bell CE, Laposata EA, Majerus PW. Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain. Blood 1986;67:362-365. (Pubitemid 16164649)
4. Wong VL, Hofman FM, Ishii H, Fisher M. Regional distribution of thrombomodulin in human brain. Brain Res 1991;556:1-5.
5. Tran N, Wong VLY, Schreiber SS, Bready J, Fisher M. Regulation of brain capillary endothelial thrombomodulin mRNA expression. Stroke 1996;27:2304-2311. (Pubitemid 26427210)
6. Rosenberg RD, Aird WC. Vascular-bed-specific hemostasis and hypercoagulable states. N Engl J Med 1999;340: 1555-1564.
7. Macko RF, Killewich LA, Fernandez JA, Cox DK, Gruber A, Griffin JH. Brain-specific protein C activation during carotid artery occlusion in humans. Stroke 1999;30:542-545. (Pubitemid 29115389)
8. Olivot J-M, Labreuche J, De Brouker T, et al. Thrombomodulin gene polymorphisms in brain infarction and mortality after stroke. J Neurol 2008;255:514-519.
9. Weiler-Guettler H, Christie PD, Beeler DL, et al. A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state. J Clin Invest 1998;101: 1983-1991. (Pubitemid 28226118)
10. Maroney SA, Cooley BC, Sood R, Weiler H, Mast AE. Combined tissue factor pathway inhibitor and thrombomodulin deficiency produces an augmented hypercoagulable state with tissue-specific fibrin deposition. J Thromb Haemost 2008;6:111-117.