Evaluation of the role of Candida albicans agglutinin-like sequence (ALS) proteins in human oral epithelial cell interactions

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Murciano, Celia ^a   Moyes, David L ^a   Runglall, Manohursingh ^a   Tobouti, Priscila ^a   Islam, Ayesha ^a   Hoyer, Lois L ^b   Naglik, Julian R ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; AGGLUTININ LIKE SEQUENCE PROTEIN; CYTOKINE; FUNGAL PROTEIN; GLYCOPROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; PROTEIN C FOS; UNCLASSIFIED DRUG; ALS3 PROTEIN, CANDIDA ALBICANS; CELL ADHESION MOLECULE; DUSP1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1;

ARTICLE; CANDIDA ALBICANS; CELL ADHESION; CELL DAMAGE; CELL INTERACTION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FUNGUS HYPHAE; MOUTH MUCOSA; MULTIGENE FAMILY; NONHUMAN; PHENOTYPE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING; YEAST; CYTOLOGY; EPITHELIUM CELL; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CANDIDA ALBICANS; FUNGI;

BLOTTING, WESTERN; CELL ADHESION MOLECULES; CYTOKINES; DUAL SPECIFICITY PHOSPHATASE 1; EPITHELIAL CELLS; FUNGAL PROTEINS; HUMANS; MOUTH MUCOSA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FOS; SIGNAL TRANSDUCTION;

EID: 84858052898     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033362     Document Type: Article

References (38)

1. Odds FC, (1988) Candida and Candidosis. Bailliere Tindall, Philadelphia.
2. Calderone RA, (2002) Candida and Candidiasis. ASM Press, Washington DC.
3. Calderone RA, Fonzi WA, (2001) Virulence factors of Candida albicans. Trends Microbiol 9: 327-335.
4. Naglik J, Albrecht A, Bader O, Hube B, (2004) Candida albicans proteinases and host/pathogen interactions. Cell Microbiol 6: 915-926.
5. Naglik JR, Challacombe SJ, Hube B, (2003) Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev 67: 400-428.
6. Soll DR, (2002) Phenotypic switching. In: Calderone RA, editors. Candida and Candidiasis pp. 123-142 ASM press, Washington, D.C.
7. Hoyer LL, Green CB, Oh SH, Zhao X, (2008) Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family- a sticky pursuit. Med Mycol 46: 1-15.
8. Hoyer LL, (2001) The ALS gene family of Candida albicans. Trends Microbiol 9: 176-180.
9. Kapteyn JC, Hoyer LL, Hecht JE, Muller WH, Andel A, et al. (2000) The cell wall architecture of Candida albicans wild-type cells and cell wall-defective mutants. Mol Microbiol 35: 601-611.
10. Salgado PS, Yan R, Taylor JD, Burchell L, Jones R, et al. (2011) Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans. Proc Natl Acad Sci U S A 108: 15775-15779.
11. Liu Y, Filler SG, (2011) Candida albicans Als3, a multifunctional adhesin and invasin. Eukaryot Cell 10: 168-173.
12. Coleman DA, Oh SH, Zhao X, Zhao H, Hutchins JT, et al. (2009) Monoclonal antibodies specific for Candida albicans Als3 that immunolabel fungal cells in vitro and in vivo and block adhesion to host surfaces. J Microbiol Methods 78: 71-78.
13. Zakikhany K, Naglik JR, Schmidt-Westhausen A, Holland G, Schaller M, et al. (2007) In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination. Cell Microbiol 9: 2938-2954.
14. Naglik JR, Moyes D, Makwana J, Kanzaria P, Tsichlaki E, et al. (2008) Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. Microbiology 154: 3266-3280.
15. Naglik JR, Fostira F, Ruprai J, Staab JF, Challacombe SJ, et al. (2006) Candida albicans HWP1 gene expression and host antibody responses in colonization and disease. J Med Microbiol 55: 1323-1327.
16. Moyes DL, Runglall M, Murciano C, Shen C, Nayar D, et al. (2010) A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells. Cell Host Microb 8: 225-235.
17. Moyes D, Murciano C, Runglall M, Kohli A, Islam A, et al. (2011) Activation of MAPK/c-Fos induced responses in oral epithelial cells is specific to Candida albicans and Candida dubliniensis hyphae. Med Microbiol Immunol 201: 93-101.
18. Murciano C, Moyes DL, Runglall M, Islam A, Mille C, et al. (2011) Candida albicans cell wall glycosylation may be indirectly required for activation of epithelial cell proinflammatory responses. Infect Immun 79: 4902-4911.
19. Naglik JR, Moyes DL, Wachtler B, Hube B, (2011) Candida albicans interactions with epithelial cells and mucosal immunity. Microbes Infect 13: 963-976.
20. Gillum AM, Tsay EY, Kirsch DR, (1984) Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet 198: 179-182.
21. Zhao X, Oh SH, Cheng G, Green CB, Nuessen JA, et al. (2004) ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1p. Microbiology 150: 2415-2428.
22. Zhao X, Oh SH, Yeater KM, Hoyer LL, (2005) Analysis of the Candida albicans Als2p and Als4p adhesins suggests the potential for compensatory function within the Als family. Microbiology 151: 1619-1630.
23. Zhao X, Oh SH, Hoyer LL, (2007) Deletion of ALS5, ALS6 or ALS7 increases adhesion of Candida albicans to human vascular endothelial and buccal epithelial cells. Med Mycol 45: 429-434.
24. Zhao X, Oh SH, Hoyer LL, (2007) Unequal contribution of ALS9 alleles to adhesion between Candida albicans and human vascular endothelial cells. Microbiology 153: 2342-2350.
25. Fonzi WA, Irwin MY, (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics 134: 717-728.
26. Murad AM, Lee PR, Broadbent ID, Barelle CJ, Brown AJ, (2000) CIp10, an efficient and convenient integrating vector for Candida albicans. Yeast 16: 325-327.
27. Zhao X, Daniels KJ, Oh SH, Green CB, Yeater KM, et al. (2006) Candida albicans Als3p is required for wild-type biofilm formation on silicone elastomer surfaces. Microbiology 152: 2287-2299.
28. Rupniak HT, Rowlatt C, Lane EB, Steele JG, Trejdosiewicz LK, et al. (1985) Characteristics of four new human cell lines derived from squamous cell carcinomas of the head and neck. J National Cancer Inst 75: 621-635.
29. Weindl G, Naglik JR, Kaesler S, Biedermann T, Hube B, et al. (2007) Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest 117: 3664-3672.
30. Schaller M, Zakikhany K, Naglik JR, Weindl G, Hube B, (2006) Models of oral and vaginal candidiasis based on in vitro reconstituted human epithelia. Nat Protoc 1: 2767-2773.
31. Stylianou E, Saklatvala J, (1998) Interleukin-1. Int J Biochem Cell Biol 30: 1075-1079.
32. Sims JE, Smith DE, (2010) The IL-1 family: regulators of immunity. Nat Rev Immunol 10: 89-102.
33. Phan QT, Myers CL, Fu Y, Sheppard DC, Yeaman MR, et al. (2007) Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells. PLoS Biol 5: e64.
34. Hoyer LL, Payne TL, Bell M, Myers AM, Scherer S, (1998) Candida albicans ALS3 and insights into the nature of the ALS gene family. Curr Genetics 33: 451-459.
35. Sheppard DC, Yeaman MR, Welch WH, Phan QT, Fu Y, et al. (2004) Functional and Structural Diversity in the Als Protein Family of Candida albicans. J Biol Chem 279: 30480-30489.
36. Coleman DA, Oh SH, Zhao X, Hoyer LL, (2010) Heterogeneous distribution of Candida albicans cell-surface antigens demonstrated with an Als1-specific monoclonal antibody. Microbiology 156: 3645-3659.
37. Zhao X, Oh SH, Coleman DA, Hoyer LL, (2011) ALS51, a newly discovered gene in the Candida albicans ALS family, created by intergenic recombination: analysis of the gene and protein, and implications for evolution of microbial gene families. FEMS Immunol Med Microbiol.
38. Moreno-Ruiz E, Galan-Diez M, Zhu W, Fernandez-Ruiz E, d'Enfert C, et al. (2009) Candida albicans internalization by host cells is mediated by a clathrin-dependent mechanism. Cell Microbiol 11: 1179-1189.