Tissue tolerable plasma and polihexanide: Are synergistic effects possible to promote healing of chronic wounds? in Vivo and in Vitro results

NATO Science for Peace and Security Series A: Chemistry and Biology

Volumn , Issue , 2012, Pages 321-334

  Bender, Claudia P ^a,b   Hübner, Nils Olaf ^a   Weltmann, Klaus Dieter ^c   Scharf, Christian ^a   Kramer, Axel ^a  

^a UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^b Private Practice   (Germany)

^c LEIBNIZ INSTITUTE FOR PLASMA SCIENCE AND TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS); CANIS FAMILIARIS;

EID: 84858035223     PISSN: 18746489     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-2852-3_25     Document Type: Conference Paper

References (28)

1. James GC, Swogger E, Wolcott R, de Lancey Pilcini E, Secor P, Sestrich J, Costerton JW, Stewart PS (2008) Biofi lms in chronic wounds. Wound Repair Regen 16:37-44
2. Davis SC, Ricotti C, Cazzaniga A, Welsh E, Eaglstein WH, Mertz PM (2008) Microscopic and physiologic evidence for biofi lm-associated wound colonization in vivo. Wound Repair Regen 16:23-29
3. Lloyd G, Friedman G, Jafri S, Schultz G, Fridman A, Harding K (2010) Gas plasma: medical uses and developments in wound care. Plasma Process Polym 7:194-211
4. Bender C, Matthes R, Kindel E, Kramer A, Lademann J, Weltmann K-D, Eisenbeiß W, Hüber N-O (2010) The irritation potential of nonthermal atmospheric pressure plasma in the HETCAM. Plasma Process Polym 7:318-326
5. Bender C, Partecke L-I, Kindel E, Döring F, Lademann J, Heidecke C-D, Kramer A, Hübner N-O (2011) The modifi ed HET-CAM as a model for the assessment of the infl ammatory response to tissue tolerable plasma. Toxicol In Vitro 25:530-537
6. Daeschlein G, von Woedtke T, Kindel E, Brandenburg R, Weltmann K-D, Juenger M (2010) Antibacterial activity of an atmospheric pressure plasma jet against relevant wound pathogens in vitro on a simulated wound environment. Plasma Process Polym 7:224
7. Hammann A, Huebner NO, Bender C, Ekkernkamp A, Hartmann B, Hinz P, Kindel E, Koban I, Koch S, Kohlmann T, Lademann J, Matthes R, Müller G, Titze R, Weltmann KD, Kramer A (2010) Antiseptic effi cacy and tolerance of tissue-tolerable plasma compared with two wound antiseptics on artifi cially bacterially contaminated eyes from commercially slaughtered pigs. Skin Pharmacol Physiol 23:328-332
8. Koban I, Matthes R, Hübner NO, Welk A, Meisel P, Holtfreter B, Sietmann R, Kindel E, Weltmann KD, Kramer A, Kocher T (2010) Treatment of Candida albicans biofi lms with low temperature plasma induced by dielectric barrier discharge and atmospheric pressure plasma jet. New J Phys 12:073039
9. Hübner NO, Matthes R, Koban I, Rändler C, Müller G, Bender C, Kindel E, Kocher T, Kramer A (2010) Effi cacy of chlorhexidine, polihexanide and tissue-tolerable plasma against pseudomonas aeruginosa biofi lms grown on polystyrene and silicone materials. Skin Pharmacol Physiol 23(suppl1):28-34
10. Hübner N-O, Kramer A (2010) Review on the effi cacy, safety and clinical applications of polihexanide, a modern wound antiseptic. Skin Pharmacol Physiol 23(suppl1):17-27
11. Roth C, Beule AG, Kramer A, Hosemann W, Kohlmann T, Scharf C (2010) Response analysis of stimulating effi cacy of polihexanide in an in vitro wound model with respiratory ciliary epithelial cells. Skin Pharmacol Physiol 23(suppl1):35-40
12. Kramer A, Roth B, Müller G, Rudolph P, Klöcker N (2004) Infl uence of the antiseptic agents polihexanide and octenidine on FL cells and on healing of experimental superfi cial aseptic wounds in piglets. A double-blind, randomised, stratifi ed, controlled, parallelgroup study. Skin Pharmacol Physiol 17:141-146 (Pubitemid 38478889)
13. Weltmann KD, Kindel E, Brandenburg R, Meyer C, Bussiahn R, Wilke C, von Woedtke T (2009) Atmospheric pressure plasma jet for medical therapy: plasma parameters and risk estimation. Contrib Plasma Phys 49:631-640
14. Poumay Y, Dupont F, Marcoux S, Leclercq-Smekens M, Hérin M, Coquette A (2004) A simple reconstructed human epidermis: preparation of the culture model and utilization in in vitro studies. Arch Dermatol Res 296:203-211 (Pubitemid 39506516)
15. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immun Methods 65(1-2):55-63 (Pubitemid 14203433)
16. Luepke NP (1985) Hen's egg chorion allantoic membrane test for irritation potential. Food Chem Toxicol 23:287-291 (Pubitemid 15004660)
17. Kramer A, Behrens-Baumann W (1997) Prophylactic use of topical anti-infectives in ophthalmology. Ophthalmologica 211:68-76 (Pubitemid 27110070)
18. Scheel J, Kleber M, Kreutz J, Lehringer E, Mehling A, Reisinger K, Steiling W (2011) Eye irritation potential: usefulness of the HET-CAM under the globally harmonized system of classifi cation and labeling of chemicals (GHS). Regul Toxicol Pharmacol 59(3):471-492
19. Stoffels E (2007) Tissue processing with atmospheric plasmas. Contrib Plasma Phys 47:40-48
20. Laroussi M (2005) Low temperature plasma-based sterilization: overview and state-of-the-art. Plasma Process Polym 2:391-400 (Pubitemid 41064407)
21. Wang Q, Turlington A, Heo S, Blanco A, Tian J, Xie Z, Yan B, Wan Y (2005) Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes. Int J Mol Med 15:633-640
22. Brenneisen P, Sies H, Scharffetter-Kochanek K (2002) Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events. Ann NY Acad Sci 973:31-43 (Pubitemid 137597861)
23. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T (1995) Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270:296-299
24. González-Rubio M, Voit S, Rodríguez-Puyol D, Weber M, Marx M (1996) Oxidative stress induces tyrosine phosphorylation of PDGF alpha-and beta-receptors and pp 60c-src in mesangial cells. Kidney Int 50:164-173 (Pubitemid 26323710)
25. Rubin JE, Chirino-Trejo M (2010) Pharyngeal, rectal and nasal colonization of clinically healthy dogs with Staphylococcus aureus. Vet Microbiol 143:440-441
26. Saphir DA, Carter GR (1976) Gingival fl ora of the dog with special reference to bacteria associated with bites. J Clin Microbiol 3:344-349
27. Stepanovic S, Dimitrijevic V, Vukovic D, Dakoc I, Sacic B, Svabic-Vlahovic M (2001) Staphylococcus sciuri as a part of skin, nasal and oral fl ora in healthy dogs. Vet Microbiol 82:177-185
28. Dissemond J, Gerber V, Kramer A, Riepe G, Strohal R, Vasel-Biergans A, Eberlein T (2010) A Practice-oriented recommendation for the treatment of critical colonised and local infected wounds using polihexanide. J Tissue Viability 19(3):106-115