The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Biasini, Emiliano ^a,b,c   Turnbaugh, Jessie A ^a   Massignan, Tania ^a,b,c   Veglianese, Pietro ^c   Forloni, Gianluigi ^c   Bonetto, Valentina ^b,c   Chiesa, Roberto ^b,c   Harris, David A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DULBECCO TELETHON INSTITUTE   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; MUTANT PROTEIN; PHLEOMYCIN; PRION PROTEIN; BLEOMYCIN; MEMBRANE PROTEIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL SPECIFICITY; COCULTURE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OLIGODENDROGLIA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE; ANIMAL; CELL COMMUNICATION; CELL CULTURE; CELL STRAIN HEK293; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; MUTATION; NICK END LABELING; PHYSIOLOGY; TIME LAPSE IMAGING; WESTERN BLOTTING;

MUS; MUS MUSCULUS;

ANIMALS; BLEOMYCIN; BLOTTING, WESTERN; CELL COMMUNICATION; CELLS, CULTURED; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; IN SITU NICK-END LABELING; MEMBRANE PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MUTATION; NEURAL STEM CELLS; PRPC PROTEINS; TIME-LAPSE IMAGING;

EID: 84858025365     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033472     Document Type: Article

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