The use of parallel segmented outlet flow columns for enhanced mass spectral sensitivity at high chromatographic flow rates

Rapid Communications in Mass Spectrometry

Volumn 26, Issue 8, 2012, Pages 943-949

  Camenzuli, Michelle ^a   Goodie, Tiffany A ^b   Bassanese, Danielle N ^b   Francis, Paul S ^b   Barnett, Neil W ^b   Ritchie, Harald ^c   Ladine, James ^c   Shalliker, R Andrew ^a   Conlan, Xavier A ^b  

^a UNIVERSITY OF WESTERN SYDNEY   (Australia)

^b DEAKIN UNIVERSITY   (Australia)

^c Thermo Fisher Scientific   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLUMN CHROMATOGRAPHY; EFFICIENCY; ELECTROSPRAY IONIZATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; PARALLEL FLOW; THROUGHPUT;

'CURRENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIES; MASS SPECTRAL; MS DETECTION; OUTLET FLOWS; POST-COLUMN; SEGMENTED FLOW; SPECTRAL SENSITIVITY; SPLITTINGS; ULTRA-HIGH;

MASS SPECTROMETERS;

EID: 84858016904     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.6176     Document Type: Article

References (15)

1. G. A. Theodoridis, H. G. Gika, E. J. Want, I. D. Wilson,. Liquid chromatography-mass spectrometry based global metabolite profiling: A review. Anal. Chim. Acta 2012, 711, 7.
2. K. Laursen, U. Justesen, M. A. Rasmussen,. Enhanced monitoring of biopharmaceutical product purity using liquid chromatography-mass spectrometry. J. Chromatogr. A 2011, 1218, 4340.
3. D. Guillarme, J. Schappler, S. Rudaz, J. Veuthey,. Coupling ultra-high-pressure liquid chromatography with mass spectrometry. Trends Anal. Chem. 2010, 29, 15.
4. G. Guichon,. Monolithic columns in high performance liquid chromatography. J. Chromatogr. A 2007, 1168, 101.
5. X. A. Conlan, S. A. Bellomarino, R. M. Parker, N. W. Barnett, M. J. Adams,. Partial least squares and principal components analysis of wine vintage by high performance liquid chromatography with chemiluminescence detection. Anal. Chim. Acta 2010, 678, 34.
6. X. A. Conlan, N. Stupka, G. P. McDermott, N. W. Barnett, P. S. Francis,. Correlation between permanganate chemiluminescence and in vitro cell culture assay: Physiologically-meaningful antioxidant activity of molecules. Anal. Methods 2010, 2, 171.
7. A. Bruins,. Mass spectrometry with ion sources operating at atmospheric pressure. Mass Spectrom. Rev. 1991, 10, 53.
8. D. C. Gale, R. D. Smith,. Small volume and low flow-rate electrospray ionization mass spectrometry of aqueous samples. Rapid Commun. Mass Spectrom. 1993, 7, 101.
9. M. S. Wilm, M. Mann,. Electrospray and Taylor-cone theory, Dole's beam of macromolecules at last? Int. J. Mass Spectrom. 1994, 136, 167.
10. C. L. Andrews, C. Yu, E. Yang, P. Vouros,. Improved liquid chromatography-mass spectrometry performance in quantitative analysis using a nanosplitter interface. J. Chromatogr. A 2004, 1053, 151.
11. M. Rajanikanth, K. P. Madhusudanan, R. C. Gupta,. An HPLC-MS method for simultaneous estimation of α,β-arteether and its metabolite dihydroartemisinin, in rat plasma for application to pharmacokinetic study. Biomed. Chromatogr. 2003, 17, 440.
12. L. Vanhaecke, J. Vanden Bussche, K. Wille, K. Bekaert, H. F. De Brabander,. Ultra-high performance liquid chromatography-tandem mass spectrometry in high-throughput confirmation and quantification of 34 anabolic steroids in bovine muscle. Anal. Chim. Acta 2011, 700, 70.
13. M. Camenzuli, H. J. Ritchie, J. R. Ladine, R. A. Shalliker,. Enhanced separation performance using a new column technology: Parallel segmented outlet flow. J. Chromatogr. A 2011, in press. DOI: 10.1016/j.chroma.2011.09.021.
14. J. Abian, A. J. Oosterkamp,., E. Gelpí,. Comparison of conventional, narrow-bore and capillary liquid chromatography/mass spectrometry for electrospray ionization mass spectrometry: practical considerations. J. Mass Spectrom. 1999, 34, 244.
15. H. Cai, J. P. Kiplinger, W. K. Goetzinger, R. O. Cole, K. A. Laws, M. Foster, A. Schrock,. A straightforward means of coupling preparative high-performance liquid chromatography and mass spectrometry. Rapid Commun. Mass Spectrom. 2002, 16, 544.