Omitting elective nodal irradiation during thoracic irradiation in limited-stage small cell lung cancer - Evidence from a phase II trial

Lung Cancer

Volumn 76, Issue 1, 2012, Pages 72-77

  Colaco, Rovel ^a   Sheikh, Hamid ^a   Lorigan, Paul ^a   Blackhall, Fiona ^a   Hulse, Paul ^a   Califano, Raffaele ^a   Ashcroft, Linda ^a   Taylor, Paul ^a,b   Thatcher, Nicholas ^a   Faivre Finn, Corinne ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Elective nodal irradiation; Limited stage; Nodal relapse; Radiotherapy; Small cell lung cancer

Indexed keywords

CISPLATIN; ETOPOSIDE;

ADULT; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RELAPSE; CANCER SIZE; CHEMORADIOTHERAPY; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISTANT METASTASIS; ELECTIVE NODAL IRRADIATION; ESOPHAGITIS; FEMALE; FOLLOW UP; HUMAN; LIMITED STAGE SMALL CELL LUNG CANCER; LIVER METASTASIS; LUNG SMALL CELL CANCER; LUNG TOXICITY; LYMPH NODE METASTASIS; MALE; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE; RADIATION FIELD; RADIATION PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; THORACIC IRRADIATION;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CISPLATIN; COMBINED MODALITY THERAPY; ETOPOSIDE; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG NEOPLASMS; LYMPHATIC IRRADIATION; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; RADIOTHERAPY, CONFORMAL; SMALL CELL LUNG CARCINOMA; THORAX;

EID: 84858002848     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2011.09.015     Document Type: Article

References (24)

1. Stahel R., Ginsberg R., Havemann K., Hirsch F., Ihde D., Jassem J., et al. Staging and prognostic factors in small cell lung cancer: a consensus report. Lung Cancer 1989, 5:119-126.
2. Vallières E., Shepherd F.A., Crowley, Van Houtte P., Postmus P.E., Carney D., et al. The IASLC Lung Cancer Staging Project: proposals regarding the relevance of TNM in the pathologic staging of small cell lung cancer in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol 2009, 4(9):1049-1059.
3. Bayman N., Sheikh H., Kularatne B., Lorigan P., Blackhall F.H., Thatcher N., et al. Radiotherapy for small-cell lung cancer - where are we heading?. Lung Cancer 2009, 63(3):307-314.
4. Faivre-Finn C., Lorigan P., West C., Thatcher N. Thoracic radiation therapy for limited-stage small-cell lung cancer: unanswered questions. Clin Lung Cancer 2005, 7:23-29.
5. De Ruysscher D., Pijls-Johannesma M., Vansteenkiste J., Kester A., Rutten I., Lambin P. Systematic review and meta-analysis of randomised, controlled trials of the timing of chest radiotherapy in patients with limited-stage, small-cell lung cancer. Ann Oncol 2006, 17:543-552.
6. Fried D.B., Morris D.E., Poole C., Rosenman J.G., Halle J.S., Detterbeck F.C., et al. Systematic review evaluating the timing of thoracic radiation therapy in combined modality therapy for limited-stage small-cell lung cancer. J Clin Oncol 2004, 22:4837-4845.
7. Huncharek M., McGarry R. A meta-analysis of the timing of chest irradiation in the combined modality treatment of limited-stage small cell lung cancer. Oncologist 2004, 9:665-672.
8. Turrisi A.T., Kim K., Blum R., Sause W.T., Livingston R.B., Komaki R., et al. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med 1999, 340:265-271.
9. Faivre-Finn C., Blackhall F., Thatcher N., Taylor P., Ashcroft L., Rowbottom C., et al. Feasibility and toxicity report from a phase II study of accelerated twice-daily (BDRT) versus high dose once-daily thoracic radiotherapy (ODRT) with concurrent chemotherapy for limited stage small cell lung cancer (LS-SCLC). J Clin Oncol 2008, 26:7583. [meeting abstracts].
10. Bonner J.A., Sloan J.A., Shanahan T.G., Brooks B.J., Marks R.S., Krook J.E., et al. Phase III comparison of twice-daily split-course irradiation versus once-daily irradiation for patients with limited stage small-cell lung carcinoma. J Clin Oncol 1999, 17:2681-2691.
11. Jeremic B., Shibamoto Y., Acimovic S., Milisavljevic S. Initial versus delayed accelerated hyperfractionated radiation therapy and concurrent chemotherapy in limited small-cell lung cancer: a randomized study. J Clin Oncol 1997, 15:893-900.
12. Takada M., Fukuoka M., Kawahara M., Sugiura T., Yokoyama A., Yokota S., et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer: results of the Japan Clinical Oncology Group Study 9104. J Clin Oncol 2002, 20:3054-3060.
13. De Ruysscher D., Bremer R., Koppe F., Wanders S., van Haren E., Hochstenbag M., et al. Omission of elective node irradiation on basis of CT-scans in patients with limited disease small cell lung cancer: a phase II trial. Radiother Oncol 2006, 80:307-312.
14. Baas P., Belderbos J.S.A., Senan S. Concurrent chemotherapy (carboplatin, paclitaxel, etoposide) and involved-field radiotherapy in limited stage small cell lung cancer: a Dutch multicenter phase II study. Br J Cancer 2006, 94:625-630.
15. van Loon J., De Ruysscher D., Wanders R., Boersma L., Simons J., Oellers M., et al. Selective nodal irradiation on basis of (18)FDG-PET scans in limited-disease small-cell lung cancer: a Prospective Study. Int J Radiat Oncol Biol Phys 2010, 77:329-336.
16. Website: http://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcaev3.pdf.
17. Sulman E.P., Komaki R., Klopp A.H., Cox J.D., Chang J.Y. Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in nonsmall cell lung cancer. Radiat Oncol 2009, 30:4-5.
18. Videtic G.M., Belderbos J.S., Spring Kong F.M., Kepka L., Martel M.K., Jeremic B. Report from the International Atomic Energy Agency (IAEA) consultants' meeting on elective nodal irradiation in lung cancer: small-cell lung cancer (SCLC). Int J Radiat Oncol Biol Phys 2008, 72:327-334.
19. Rosenzweig K., Sim S., Mychalczak B., Braban L.E., Schindelheim R., Leibel S.A. Elective nodal irradiation in the treatment of non-small-cell lung cancer with three-dimensional conformal radiation therapy. Int J Radiat Oncol Biol Phys 2001, 50:681-685.
20. Senan S., Burgers S., Samson M.J., van Klaveren R.J., Oei S.S., van Sörnsen de Koste J., et al. Can elective nodal irradiation be omitted in stage III non-small-cell lung cancer? Analysis of recurrences in a phase II study of induction chemotherapy and involved-field radiotherapy. Int J Radiat Oncol Biol Phys 2002, 54:999-1006.
21. Belderbos J.S., Baas P., Senan S. Reply patterns of nodal recurrence after omission of elective nodal irradiation for limited-stage small cell lung cancer. Br J Cancer 2007, 97:276.
22. van Loon J., Offermann C., Bosmans G., Wanders R., Dekker A., Borger J., et al. 18FDG-PET based radiation planning of mediastinal lymph nodes in limited disease small cell lung cancer changes radiotherapy fields: a planning study. Radiother Oncol 2008, 87(1):49-54.
23. Shirvani K., Komaki R., Heymach J., Fossella F.V., Chang J.Y. Positron emission tomography/computer tomography guided intensity modulated radiotherapy for limited-stage small cell lung cancer. Int J Radiat Oncol Biol Phys 2011, [Epub ahead of print].
24. Faivre-Finn C., Blackhall F.H., Snee M., Harden S., Hulse P., Lorigan P. Improving survival with thoracic radiotherapy in patients with small cell lunch cancer. The CONVERT and the REST trails. Clin Oncol (R Coll Radiol) 2010, 22:547-549.