Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons

BMC Genomics

Volumn 13, Issue 1, 2012, Pages

  Lejeune, François Xavier ^a   Mesrob, Lilia ^a   Parmentier, Frédéric ^a   Bicep, Cedric ^a,b   Vazquez Manrique, Rafael P ^a,b   Parker, J Alex ^a,b,c   Vert, Jean Philippe ^a,d,e   Tourette, Cendrine ^a,b,f   Neri, Christian ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITY OF MONTREAL   (Canada)

^d PSL RESEARCH UNIVERSITY   (France)

^e INSTITUT CURIE   (France)

^f BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; HUNTINGTIN; POLYGLUTAMINE; HTT PROTEIN, HUMAN; NERVE PROTEIN; PEPTIDE; RNA DIRECTED RNA POLYMERASE; RNA DIRECTED RNA POLYMERASE RRF 3, C ELEGANS; RNA-DIRECTED RNA POLYMERASE RRF-3, C ELEGANS;

AMINO TERMINAL SEQUENCE; ARTICLE; CAENORHABDITIS ELEGANS; CELL DEATH; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; DEGENERATIVE DISEASE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE INACTIVATION; GENE SILENCING; GENETIC ANALYSIS; GENETIC REGULATION; HUNTINGTON CHOREA; MEC 3 GENE; MEC 7 GENE; MODULATION; MOUSE; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NONHUMAN; PROTEIN FUNCTION; RNA INTERFERENCE; ANIMAL; GENETIC ASSOCIATION; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM; MOLECULAR GENETICS; MUTATION; NERVE CELL; TRANSGENIC MOUSE;

ANIMALIA; CAENORHABDITIS ELEGANS; MUS;

ANIMALS; CAENORHABDITIS ELEGANS; CELL SURVIVAL; CORPUS STRIATUM; GENOME-WIDE ASSOCIATION STUDY; HIGH-THROUGHPUT SCREENING ASSAYS; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE ANNOTATION; MUTATION; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEURONS; PEPTIDES; RNA INTERFERENCE; RNA REPLICASE;

EID: 84857989952     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-13-91     Document Type: Article

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