Systematic review and meta-analysis of the effects of high protein oral nutritional supplements

Ageing Research Reviews

Volumn 11, Issue 2, 2012, Pages 278-296

  Cawood, A L ^a,b   Elia, M ^a   Stratton, R J ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b Nutricia Ltd   (United Kingdom)

Author keywords

Meta analysis; Nutrition; Oral nutritional supplements; Protein; Supplement

Indexed keywords

PROTEIN DERIVATIVE;

APPETITE; BODY COMPOSITION; CINAHL; COCHRANE LIBRARY; DAILY LIFE ACTIVITY; DIET SUPPLEMENTATION; DYSPNEA; ECONOMIC ASPECT; ENERGY; FOOD INTAKE; GRIP STRENGTH; HEALTH CARE UTILIZATION; HOSPITAL READMISSION; HUMAN; LENGTH OF STAY; MALNUTRITION; MEDLINE; META ANALYSIS; ORAL NUTRITIONAL SUPPLEMENT; OUTCOME ASSESSMENT; PHYSICAL MOBILITY; PROTEIN DIET; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; WEIGHT CONTROL;

ADMINISTRATION, ORAL; ADULT; AGED; AGED, 80 AND OVER; DIETARY PROTEINS; DIETARY SUPPLEMENTS; ENERGY INTAKE; ENERGY METABOLISM; ENTERAL NUTRITION; EVIDENCE-BASED MEDICINE; HUMANS; MALNUTRITION; MIDDLE AGED; NUTRITIONAL STATUS; ODDS RATIO; RECOVERY OF FUNCTION; RISK ASSESSMENT; RISK FACTORS; TREATMENT OUTCOME;

EID: 84857964604     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2011.12.008     Document Type: Review

References (169)

1. Arias S., Bruzzone I., Blanco V., Inchausti M., Garcia F., Casavieja G., Silveira R., Ruiz Diaz M.E. Identification and early nutritional support in hospitalized malnourished patients. Nutr. Hosp. 2008, 23:348-353.
2. Arnold C., Richter M.P. The effect of oral nutritional supplements on head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 1989, 16:1595-1599.
3. Arnold M., Barbul A. Nutrition and wound healing. Plast. Reconstr. Surg. 2006, 117:42S-58S.
4. Baldwin C., Weekes C.E. Dietary advice for illness-related malnutrition in adults. Cochrane Database Syst. Rev. 2009, (Review).
5. Ballard T.L., Clapper J.A., Specker B.L., Binkley T.L., Vukovich M.D. Effect of protein supplementation during a 6-mo strength and conditioning program on insulin-like growth factor I and markers of bone turnover in young adults. Am. J. Clin. Nutr. 2005, 81:1442-1448.
6. Beattie A.H., Prach A.T., Baxter J.P., Pennington C.R. A randomised controlled trial evaluating the use of enteral nutritional supplements postoperatively in malnourished surgical patients. Gut 2000, 46:813-818.
7. Beck A.M., Damkjaer K., Beyer N. Multifaceted nutritional intervention among nursing-home residents has a positive influence on nutrition and function. Nutrition 2008, 24:1073-1080.
8. Beck A.M., Ovesen L., Schroll M. Home-made oral supplement as nutritional support of old nursing home residents, who are undernourished or at risk of undernutrition based on the MNA. A pilot trial. Mini Nutritional Assessment. Aging Clin. Exp. Res. 2002, 14:212-215.
9. Benati G., Delvecchio S., Cilla D., Pedone V. Impact on pressure ulcer healing of an arginine-enriched nutritional solution in patients with severe cognitive impairment. Arch. Gerontol. Geriatr. Suppl. 2001, 7:43-47.
10. Berneis K., Battegay M., Bassetti S., Nuesch R., Leisibach A., Bilz S., Keller U. Nutritional supplements combined with dietary counselling diminish whole body protein catabolism in HIV-infected patients. Eur. J. Clin. Invest. 2000, 30:87-94.
11. Bonnefoy M., Cornu C., Normand S., Boutitie F., Bugnard F., Rahmani A., Lacour J.R., Laville M. The effects of exercise and protein-energy supplements on body composition and muscle function in frail elderly individuals: a long-term controlled randomised study. Br. J. Nutr. 2003, 89:731-738.
12. Borenstein M., Hedges L.V., Higgins J.P.T., Rothstein H.R. Introduction to Meta-analysis (Statistics in Practice) 2009, John Wiley and Sons, UK.
13. Bos C., Benamouzig R., Bruhat A., Roux C., Mahe S., Valensi P., Gaudichon C., Ferriere F., Rautureau J., Tome D. Short-term protein and energy supplementation activates nitrogen kinetics and accretion in poorly nourished elderly subjects. Am. J. Clin. Nutr. 2000, 71:1129-1137.
14. Bos C., Benamouzig R., Bruhat A., Roux C., Valensi P., Ferriere F., Tome D. Nutritional status after short-term dietary supplementation in hospitalized malnourished geriatric patients. Clin. Nutr. 2001, 20:225-233.
15. Botella-Carretero J.I., Iglesias B., Balsa J.A., Zamarron I., Arrieta F., Vazquez C. Effects of oral nutritional supplements in normally nourished or mildly undernourished geriatric patients after surgery for hip fracture: a randomized clinical trial. JPEN. J. Parenter. Enteral Nutr. 2008, 32:120-128.
16. Bourdel-Marchasson I., Barateau M., Rondeau V., Dequae-Merchadou L., Salles-Montaudon N., Emeriau J.P., Manciet G., Dartigues J.F. A multi-center trial of the effects of oral nutritional supplementation in critically ill older inpatients. GAGE Group. Groupe Aquitain Geriatrique d'Evaluation. Nutrition 2000, 16:1-5.
17. Bruce D., Laurance I., McGuiness M., Ridley M., Goldswain P. Nutritional supplements after hip fracture: poor compliance limits effectiveness. Clin. Nutr. 2003, 22:497-500.
18. Bunout D., Barrera G., de la Maza P., Avendano M., Gattas V., Petermann M., Hirsh S. Effects of nutritional supplementation and resistance training on muscle strength in free living elders. Results of one year follow. J. Nutr. Health Aging 2004, 8:68-75.
19. Bunout D., Barrera G., Leiva L., Gattas V., de la Maza M.P., Haschke F., Steenhout P., Klassen P., Hager C., Offord E., Hirsch S. Effect of a nutritional supplementation on bone health in chilean elderly subjects with femoral osteoporosis. J. Am. Coll. Nutr. 2006, 25:170-177.
20. Caglar K., Fedje L., Dimmitt R., Hakim R.M., Shyr Y., Ikizler T.A. Therapeutic effects of oral nutritional supplementation during hemodialysis. Kidney Int. 2002, 62:1054-1059.
21. Calder P.C. Fuel utilization by cells of the immune system. Proc. Nutr. Soc. 1995, 54:65-82.
22. Carlsson P., Tidermark J., Ponzer S., Soderqvist A., Cederholm T. Food habits and appetite of elderly women at the time of a femoral neck fracture and after nutritional and anabolic support. J. Hum. Nutr. Diet 2005, 18:117-120.
23. Centre for Reviews and Dissemination, University of York Systematic Reviews: CRD's Guidelines for Undertaking Reviews in Health Care 2009.
24. Cereda E., Gini A., Pedrolli C., Vanotti A. Disease-specific, versus standard, nutritional support for the treatment of pressure ulcers in institutionalized older adults: a randomized controlled trial. J. Am. Geriatr. Soc. 2009, 57:1395-1402.
25. Champagne C.M., Baker N.B., DeLany J.P., Harsha D.W., Bray G.A. Assessment of energy intake underreporting by doubly labeled water and observations on reported nutrient intakes in children. J. Am. Diet. Assoc. 1998, 98:428-433.
26. Chapman I.M., Visvanathan R., Hammond A.J., Morley J.E., Field J.B., Tai K., Belobrajdic D.P., Chen R.Y., Horowitz M. Effect of testosterone and a nutritional supplement, alone and in combination, on hospital admissions in undernourished older men and women. Am. J. Clin. Nutr. 2009, 89:880-889.
27. Collins C.E., Kershaw J., Brockington S. Effect of nutritional supplements on wound healing in home-nursed elderly: a randomized trial. Nutrition 2005, 21:147-155.
28. Creutzberg E.C., Schols A.M.W.J., Weling-Scheepers C.A.P.M., Buurman W.A., Wouters E.F.M. Characterization of nonresponse to high caloric oral nutritional therapy in depleted patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2000, 161:745-752.
29. Curtis L. Unit Cost of Health and Social Care 2010, Personal Social Services Research Unit, University of Kent, Canterbury.
30. D'antoni G.B., Sucher K.P., Coulston A.M. Dietary intake of at-risk, free-living elderly subjects receiving meals-on-wheels and a dietary supplement. J. Am. Diet. Assoc. 1996, 96:A79.
31. de Luis D.A., Izaola O., Aller R., Cuellar L., Terroba M.C., Martin T. A randomized clinical trial with two omega 3 fatty acid enhanced oral supplements in head and neck cancer ambulatory patients. Eur. Rev. Med. Pharmacol. Sci. 2008, 12:177-181.
32. de Luis D.A., Izaola O., Aller R., Cuellar L., Terroba M.C., Martin T., Cabezas G., Rojo S., Domingo M. A randomized clinical trial with two enteral diabetes-specific supplements in patients with diabetes mellitus type 2: metabolic effects. Eur. Rev. Med. Pharmacol. Sci. 2008, 12:261-266.
33. de Luis D.A., Izaola O., Cuellar L., Terroba M.C., Martin T., Aller R. Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients. Eur. J. Clin. Nutr. 2007, 61:200-204.
34. Delmi M., Rapin C.H., Bengoa J.M., Delmas P.D., Vasey H., Bonjour J.P. Dietary supplementation in elderly patients with fractured neck of the femur. Lancet 1990, 335:1013-1016.
35. Department of Health and Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy, 1992. Dietary Reference Values for Food Energy and Nutrients for the United Kingdom 41.
36. Desneves K.J., Todorovic B.E., Cassar A., Crowe T.C. Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial. Clin. Nutr. 2005, 24:979-987.
37. Efthimiou J., Fleming J., Gomes C., Spiro S.G. The effect of supplementary oral nutrition in poorly nourished patients with chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1988, 137:1075-1082.
38. Elia M. Special nutritional problems and the use of enteral and parenteral nutrition. Oxford Textbook of Medicine 2003, 1073-1095. Oxford University Press, Oxford. D.A. Warrell, T.M. Cox, J.D. Firth, E.J. Benz (Eds.).
39. Elia M., Cummings J.H. Physiological aspects of energy metabolism and gastrointestinal effects of carbohydrates. Eur. J. Clin. Nutr. 2007, 61:S40-S74.
40. Elia M. Nutrition and health economics. Nutrition 2006, 22:576-578.
41. Elia M., Russell C.A. Screening for Malnutrition in Sheltered Housing. A report from BAPEN. With the Group on Nutrition in Sheltered Housing (GNASH) 2009, BAPEN, Redditch, UK.
42. Elia M., Russell C.A. Combating Malnutrition: Recommendations for Action. Report from the Advisory Group on Malnutrition, Led by BAPEN 2009.
43. Elia M., Stratton R.J. Calculating the cost of disease-related malnutrition in the UK in 2007 (public expenditure only). Combating Malnutrition: Recommendations for Action. A Report from the Advisory Group on Malnutrition, Led by BAPEN 2009, 39-46. BAPEN, Redditch, UK. Elia, Russell (Eds.).
44. Eneroth M., Larsson J., Oscarsson C., Apelqvist J. Nutritional supplementation for diabetic foot ulcers: the first RCT. J. Wound Care 2004, 13:230-234.
45. Eneroth M., Olsson U.B., Thorngren K.G. Nutritional supplementation decreases hip fracture-related complications. Clin. Orthop. Relat. Res. 2006, 451:212-217.
46. Espaulella J., Guyer H., az-Escriu F., Mellado-Navas J., Castells M., Pladevall M. Nutritional supplementation of elderly hip fracture patients. A randomized, double-blind, placebo-controlled trial. Age Ageing 2000, 29:425-431.
47. Evans W.K., Nixon D.W., Daly J.M., Ellenberg S.S., Gardner L., Wolfe E., Shepherd F.A., Feld R., Gralla R., Fine S. A randomized study of oral nutritional support versus ad lib. nutritional intake during chemotherapy for advanced colorectal and non-small-cell lung cancer. J. Clin. Oncol. 1987, 5:113-124.
48. Fiatarone Singh M.A., Bernstein M.A., Ryan N.D., O'Neill E.F., Clements K.M., Evans W.J. The effect of oral nutritional supplements on habitual dietary quality and quantity in frail elders. J. Nutr. Health Aging 2000, 4:5-12.
49. Finch S., Doyle W., Lowe C., Bates C.J., Prentice A., Smithers G., Clarke P.C. National Diet and Nutrition Survey: People Aged 65 Years and Over, vol. 1. Report of The Diet and Nutrition Survey 1998, The Stationary Office, London.
50. Flakoll P.J., Judy T., Flinn K., Carr C., Flinn S. Postexercise protein supplementation improves health and muscle soreness during basic military training in marine recruits. J. Appl. Physiol. 2004, 96:951-956.
51. Forli L., Bjortuft O., Vatn M., Kofstad J., Boe J. A study of intensified dietary support in underweight candidates for lung transplantation. Ann. Nutr. Metab. 2001, 45:159-168.
52. Gariballa S., Forster S. Dietary supplementation and quality of life of older patients: a randomized, double-blind, placebo-controlled trial. J. Am. Geriatr. Soc. 2007, 55:2030-2034.
53. Gariballa S., Forster S. Effects of dietary supplements on depressive symptoms in older patients: a randomised double-blind placebo-controlled trial. Clin. Nutr. 2007, 26:545-551.
54. Gariballa S., Forster S., Walters S., Powers H. A randomized, double-blind, placebo-controlled trial of nutritional supplementation during acute illness. Am. J. Med. 2006, 119:693-699.
55. Gariballa S.E., Parker S.G., Taub N., Castleden C.M. A randomized, controlled, a single-blind trial of nutritional supplementation after acute stroke. JPEN. J. Parenter. Enteral Nutr. 1998, 22:315-319.
56. Gegerle P., Bengoa J.M., Rapin C.H., Loizeau E., Vasey H. Dietary survey on the effect of an oral nutritional supplement after femoral neck fracture. Schweiz. Rundsch. Med. Prax. 1986, 75:933-935.
57. Gianotti L., Braga M., Nespoli L., Radaelli G., Beneduce A., Di Carlo V. A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology 2002, 122:1763-1770.
58. Gonzalez-Espinoza L., Gutierrez-Chavez J., del Campo F.M., Martinez-Ramirez H.R., Cortes-Sanabria L., Rojas-Campos E., Cueto-Manzano A.M. Randomized, open label, controlled clinical trial of oral administration of an egg albumin-based protein supplement to patients on continuous ambulatory peritoneal dialysis. Perit. Dial. Int. 2005, 25:173-180.
59. Gray-Donald K., Payette H., Boutier V. Randomized clinical trial of nutritional supplementation shows little effect on functional status among free-living frail elderly. J. Nutr. 1995, 125:2965-2971.
60. Habicht J.P., Martorell R., Rivera J.A. Nutritional impact of supplementation in the INCAP longitudinal study: analytic strategies and inferences. J. Nutr. 1995, 125:1042S-1050S.
61. Haydock D.A., Hill G.L. Impaired wound healing in surgical patients with varying degrees of malnutrition. Br. J. Surg. 1987, 74:320-323.
62. Helminen H., Raitanen M., Kellosalo J. Immunonutrition in elective gastrointestinal surgery patients. Scand. J. Surg. 2007, 96:46-50.
63. Henderson L., Gregory J., Irving K., Swan G. The National Diet and Nutrition Survey: Adults Aged 19-64 Years. Energy, Protein, Carbohydrate, Fat and Alcohol Intake 2003.
64. Heyman H., Van De Looverbosc D.E.J., Meijer E.P., Schols J.M. Benefits of an oral nutritional supplement on pressure ulcer healing in long-term care residents. J. Wound Care 2008, 17:476-480.
65. Higgins J.P., Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 2002, 21:539-558.
66. Higgins J.P., Thompson S.G., Deeks J.J., Altman D.G. Measuring inconsistency in meta-analyses. Br. Med. J. 2003, 327:557-560.
67. Hirsch S., Bunout D., de la Maza P., Iturriaga H., Petermann M., Icazar G., Gattas V., Ugarte G. Controlled trial on nutrition supplementation in outpatients with symptomatic alcoholic cirrhosis. JPEN. J. Parenter. Enteral Nutr. 1993, 17:119-124.
68. Hoffman J.R., Ratamess N.A., Tranchina C.P., Rashti S.L., Kang J., Faigenbaum A.D. Effect of protein-supplement timing on strength, power, and body-composition changes in resistance-trained men. Int. J. Sport Nutr. Exerc. Metab. 2009, 19:172-185.
69. Hoh R., Pelfini A., Neese R.A., Chan M., Cello J.P., Cope F.O., Abbruzese B.C., Richards E.W., Courtney K., Hellerstein M.K. De novo lipogenesis predicts short-term body-composition response by bioelectrical impedance analysis to oral nutritional supplements in HIV-associated wasting. Am. J. Clin. Nutr. 1998, 68:154-163.
70. Holm L., Olesen J.L., Matsumoto K., Doi T., Mizuno M., Alsted T.J., Mackey A.L., Schwarz P., Kjaer M. Protein-containing nutrient supplementation following strength training enhances the effect on muscle mass, strength, and bone formation in postmenopausal women. J. Appl. Physiol. 2008, 105:274-281.
71. Hommel A., Bjorkelund K.B., Thorngren K.G., Ulander K. Nutritional status among patients with hip fracture in relation to pressure ulcers. Clin. Nutr. 2007, 26:589-596.
72. Houwing R.H., Rozendaal M., Wouters-Wesseling W., Beulens J.W., Buskens E., Haalboom J.R. A randomised, double-blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip-fracture patients. Clin. Nutr. 2003, 22:401-405.
73. Hubsch S., Volkert D., Oster P., Schlierf G. Effect of dietary supplementation on weight and protein status in undernourished geriatric patients. Clin. Nutr. 1992, 11:97.
74. Hung S.C., Tarng D.C. Adiposity and insulin resistance in nondiabetic hemodialysis patients: effects of high energy supplementation. Am. J. Clin. Nutr. 2009, 90:64-69.
75. Iizaka S., Okuwa M., Sugama J., Sanada H. The impact of malnutrition and nutrition-related factors on the development and severity of pressure ulcers in older patients receiving home care. Clin. Nutr. 2010, 29:47-53.
76. Institute of Medicine Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Protein, and Amino Acids 2005.
77. Irvine P., Mouzet J.B., Marteau C., Salle A., Genaitay M., Favreau A.M., Berrut G., Ritz P. Short-term effect of a protein load on appetite and food intake in diseased mildly undernourished elderly people. Clin. Nutr. 2004, 23:1146-1152.
78. Isenring E.A., Capra S., Bauer J.D. Nutrition intervention is beneficial in oncology outpatients receiving radiotherapy to the gastrointestinal or head and neck area. Br. J. Cancer 2004, 91:447-452.
79. Jadad A.R., Moore R.A., Carroll D., Jenkinson C., Reynolds D.J., Gavaghan D.J., McQuay H.J. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control. Clin. Trials 1996, 17:1-12.
80. Jensen M.B., Hessov I. Dietary supplementation at home improves the regain of lean body mass after surgery. Nutrition 1997, 13:422-430.
81. Jensen M.B., Hessov I. Randomization to nutritional intervention at home did not improve postoperative function, fatigue or well-being. Br. J. Surg. 1997, 84:113-118.
82. Johnson L.E., Dooley P.A., Gleick J.B. Oral nutritional supplement use in elderly nursing home patients. J. Am. Geriatr. Soc. 1993, 41:947-952.
83. Keele A.M., Bray M.J., Emery P.W., Duncan H.D., Silk D.B. Two phase randomised controlled clinical trial of postoperative oral dietary supplements in surgical patients. Gut 1997, 40:393-399.
84. Knowles J.B., Fairbarn M.S., Wiggs B.J., Chan-Yan C., Pardy R.L. Dietary supplementation and respiratory muscle performance in patients with COPD. Chest 1988, 93:977-983.
85. Koretz R.L., Avenell A., Lipman T.O., Braunschweig C.L., Milne A.C. Does enteral nutrition affect clinical outcomes? A systematic review of the randomized trials. Am. J. Gastroenterol. 2007, 102:412-429.
86. Krondl M., Coleman P.H., Bradley C.L., Lau D., Ryan N. Subjectively healthy elderly consuming a liquid nutrition supplement maintained body mass index and improved some nutritional parameters and perceived well-being. J. Am. Diet. Assoc. 1999, 99:1542-1548.
87. Kruizenga H.M., Wierdsma N.J., Van Bokhorst-de van der Schueren M.A., Hollander H.J., Jonkers-Schuitema C.F., Van Der Heijden D., Melis G.C., van Staveren W.A. Screening for nutritional status in The Netherlands. Clin. Nutr. 2003, 22:147-152.
88. Kuhlmann M.K., Schmidt F., Kohler H. High protein/energy vs. standard protein/energy nutritional regimen in the treatment of malnourished hemodialysis patients. Miner. Electrolyte Metab. 1999, 25:306-310.
89. Kwon Lee S., Posthauer M.E., Dorner B., Redovian V., Maloney M.J. Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: a randomized controlled trial. Adv. Skin Wound Care 2006, 19:92-96.
90. Lauque S., Arnaud-Battandier F., Gillette S., Plaze J.M., Andrieu S., Cantet C., Vellas B. Improvement of weight and fat-free mass with oral nutritional supplementation in patients with Alzheimer's disease at risk of malnutrition: a prospective randomized study. J. Am. Geriatr. Soc. 2004, 52:1702-1707.
91. Lauque S., Arnaud-Battandier F., Mansourian R., Guigoz Y., Paintin M., Nourhashemi F., Vellas B. Protein-energy oral supplementation in malnourished nursing-home residents. A controlled trial. Age Ageing 2000, 29:51-56.
92. Lawson R.M., Doshi M.K., Ingoe L.E., Colligan J.M., Barton J.R., Cobden I. Compliance of orthopaedic patients with postoperative oral nutritional supplementation. Clin. Nutr. 2000, 19:171-175.
93. Le Cornu K.A., McKiernan F.J., Kapadia S.A., Neuberger J.M. A prospective randomized study of preoperative nutritional supplementation in patients awaiting elective orthotopic liver transplantation. Transplantation 2000, 69:1364-1369.
94. Lewis M.I., Belman M.J., Dorr-Uyemura L. Nutritional supplementation in ambulatory patients with chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1987, 135:1062-1068.
95. Li P., Yin Y.L., Li D., Kim S.W., Wu G. Amino acids and immune function. Br. J. Nutr. 2007, 98:237-252.
96. Lochs H., Allison S.P., Meier R., Pirlich M., Kondrup J., Schneider S., van den Berghe G., Pichard C. Introductory to the ESPEN guidelines on enteral nutrition: terminology, definitions and general topics. Clin. Nutr. 2006, 25:180-186.
97. Lockwood C.M., Moon J.R., Tobkin S.E., Walter A.A., Smith A.E., Dalbo V.J., Cramer J.T., Stout J.R. Minimal nutrition intervention with a high-protein/low-carbohydrate and low-fat, nutrient-dense food supplement improves body composition and exercise benefits in overweight adults: a randomized controlled trial. Nutr. Metab. 2008, 5:11.
98. Lundholm K., Körner U., Gunnebo L., Sixt-Ammilon P., Fouladiun M., Daneryd P., Bosaeus I. Insulin treatment in cancer cachexia: effects on survival, metabolism, and physical functioning. Clin. Cancer Res. 2007, 13:2699-2706.
99. Macfie J., Woodcock N.P., Palmer M.D., Walker A., Townsend S., Mitchell C.J. Oral dietary supplements in pre- and postoperative surgical patients: a prospective and randomized clinical trial. Nutrition 2000, 16:723-728.
100. Manders M., de Groot C.P., Blauw Y.H., Dhonukshe-Rutten R.A., van Hoeckel-Prust L., Bindels J.G., Siebelink E., van Staveren W.A. Effect of a nutrient-enriched drink on dietary intake and nutritional status in institutionalised elderly. Eur. J. Clin. Nutr. 2009, 63:1241-1250.
101. Mantovani G., Macciò A., Madeddu C., Gramignano G., Serpe R., Massa E., Dessï M., Tanca F.M., Sanna E., Deiana L., Panzone F., Contu P., Floris C. Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. Nutrition 2008, 24:305-313.
102. McCarter M.D., Gentilini O.D., Gomez M.E., Daly J.M. Preoperative oral supplement with immunonutrients in cancer patients. JPEN. J. Parenter. Enteral Nutr. 1998, 22:206-211.
103. McCarthy D., Weihofen D. The effect of nutritional supplements on food intake in patients undergoing radiotherapy. Oncol. Nurs. Forum 1999, 89:267-900.
104. McEvoy A.W., James O.F. The effect of a dietary supplement (build-up) on nutritional status in hospitalized elderly patients. Hum. Nutr. Appl. Nutr. 1982, 36:374-376.
105. McMurdo M.E., Price R.J., Shields M., Potter J., Stott D.J. Should oral nutritional supplementation be given to undernourished older people upon hospital discharge? A controlled trial. J. Am. Geriatr. Soc. 2009, 57:2239-2245.
106. Miller M.D., Crotty M., Whitehead C., Bannerman E., Daniels L.A. Nutritional supplementation and resistance training in nutritionally at risk older adults following lower limb fracture: a randomized controlled trial. Clin. Rehabil. 2006, 20:311-323.
107. Miller M.D., Daniels L.A., Bannerman E., Crotty M. Adherence to nutrition supplements among patients with a fall-related lower limb fracture. Nutr. Clin. Pract. 2005, 20:569-578.
108. Milne A.C., Potter J., Vivanti A., Avenell A. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst. Rev 2009.
109. Moher D., Liberati A., Tetzlaff J., Altman D.G. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Br. Med. J. 2009, 339:332-339. for the PRISMA Group.
110. Moretti H.D., Johnson A.M., Keeling-Hathaway T.J. Effects of protein supplementation in chronic hemodialysis and peritoneal dialysis patients. J. Ren. Nutr. 2009, 19:298-303.
111. Murakami S., Kurihara S., Koikawa N., Nakamura A., Aoki K., Yosigi H., Sawaki K., Ohtani M. Effects of oral supplementation with cystine and theanine on the immune function of athletes in endurance exercise: randomized, double-blind, placebo-controlled trial. Biosci. Biotechnol. Biochem. 2009, 73:817-821.
112. National Institute for Health and Clinical Excellence (NICE), 2006. Nutrition support in adults: oral nutrition support, enteral tube feeding and parenteral nutrition. Clinical Guideline 32.
113. Nayel H., el-Ghoneimy E., el-Haddad S. Impact of nutritional supplementation on treatment delay and morbidity in patients with head and neck tumors treated with irradiation. Nutrition 1992, 8:13-18.
114. Neumann M., Friedmann J., Roy M.A., Jensen G.L. Provision of high-protein supplement for patients recovering from hip fracture. Nutrition 2004, 20:415-419.
115. Nielsen A.A., Nielsen J.N., Gronbaek H., Eivindson M., Vind I., Munkholm P., Brandslund I., Hey H. Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn's disease treated with prednisolone. Digestion 2007, 75:10-16.
116. Norman K., Kirchner H., Freudenreich M., Ockenga J., Lochs H., Pirlich M. Three month intervention with protein and energy rich supplements improve muscle function and quality of life in malnourished patients with non-neoplastic gastrointestinal disease-a randomized controlled trial. Clin. Nutr. 2008, 27:48-56.
117. Okamoto Y., Okano K., Izuishi K., Usuki H., Wakabayashi H., Suzuki Y. Attenuation of the systemic inflammatory response and infectious complications after gastrectomy with preoperative oral arginine and omega-3 fatty acids supplemented immunonutrition. World J. Surg. 2009, 33:1815-1821.
118. Olofsson B., Stenvall M., Lundstrom M., Svensson O., Gustafson Y. Malnutrition in hip fracture patients: an intervention study. J. Clin. Nurs. 2007, 16:2027-2038.
119. Otte K.E., Ahlburg P., D'Amore F., Stellfeld M. Nutritional repletion in malnourished patients with emphysema. JPEN J. Parenter. Enteral Nutr. 1989, 13:152-156.
120. Paddon-Jones D., Short K.R., Campbell W.W., Volpi E., Wolfe R.R. Role of dietary protein in the sarcopenia of aging. Am. J. Clin. Nutr. 2008, 87:1562S-1566S.
121. Pasiakos S.M., MCClung J.P. Supplemental dietary leucine and the skeletal muscle anabolic response to essential amino acids. Nutr. Rev. 2011, 69:550-557.
122. Payette H., Boutier V., Coulombe C., Gray-Donald K. Benefits of nutritional supplementation in free-living, frail, undernourished elderly people: a prospective randomized community trial. J. Am. Diet. Assoc. 2002, 102:1088-1095.
123. Persson M., Hytter-Landahl A., Brismar K., Cederholm T. Nutritional supplementation and dietary advice in geriatric patients at risk of malnutrition. Clin. Nutr. 2007, 26:216-224.
124. Planas M., Alvarez J., Garcia-Peris P.A., de la Cuerda C., de Lucas P., Castella M., Canseco F., Reyes L. Nutritional support and quality of life in stable chronic obstructive pulmonary disease (COPD) patients. Clin. Nutr. 2005, 24:433-441.
125. Plank L.D., Gane E.J., Peng S., Muthu C., Mathur S., Gillanders L., McIlroy K., Donaghy A.J., McCall J.L. Nocturnal nutritional supplementation improves total body protein status of patients with liver cirrhosis: a randomized 12-month trial. Hepatology 2008, 48:557-566.
126. Portier H., Chatard J.C., Filaire E., Jaunet-Devienne M.F., Robert A., Guezennec C.Y. Effects of branched-chain amino acids supplementation on physiological and psychological performance during an offshore sailing race. Eur. J. Appl. Physiol. 2008, 104:787-794.
127. Potter J.M., Roberts M.A., McColl J.H., Reilly J.J. Protein energy supplements in unwell elderly patients-a randomized controlled trial. JPEN. J. Parenter. Enteral Nutr. 2001, 25:323-329.
128. Price R., Daly F., Pennington C.R., McMurdo M.E. Nutritional supplementation of very old people at hospital discharge increases muscle strength: a randomised controlled trial. Gerontology 2005, 51:179-185.
129. Raffoul W., Far M.S., Cayeux M.C., Berger M.M. Nutritional status and food intake in nine patients with chronic low-limb ulcers and pressure ulcers: importance of oral supplements. Nutrition 2006, 22:82-88.
130. Ravasco P., Monteiro-Grillo I., Marques Vidal P., Camilo M.E. Impact of nutrition on outcome: a prospective randomized controlled trial in patients with head and neck cancer undergoing radiotherapy. Head Neck 2005, 27:659-668.
131. Ravasco P., Monteiro-Grillo I., Vidal P.M., Camilo M.E. Dietary counseling improves patient outcomes: a prospective, randomized, controlled trial in colorectal cancer patients undergoing radiotherapy. J. Clin. Oncol. 2005, 23:1431-1438.
132. Regulations (EC) No. 1924/2006, 2006. European Parliament and of the Council of 20 December 2006 on nutrition and health claims made on foods. Official Journal of the European Union, L404.
133. Riso S., Aluffi P., Brugnani M., Farinetti F., Pia F., D'Andrea F. Postoperative enteral immunonutrition in head and neck cancer patients. Clin. Nutr. 2000, 19:407-412.
134. Roberts M., Potter J., McColl J., Reilly J. Can prescription of sip-feed supplements increase energy intake in hospitalised older people with medical problems?. Br. J. Nutr. 2003, 90:425-429.
135. Rogers R.M., Donahoe M., Costantino J. Physiologic effects of oral supplemental feeding in malnourished patients with chronic obstructive pulmonary disease. A randomized control study. Am. Rev. Respir. Dis. 1992, 146:1511-1517.
136. Rosendahl E., Lindelof N., Littbrand H., Yifter-Lindgren E., Lundin-Olsson L., Haglin L., Gustafson Y., Nyberg L. High-intensity functional exercise program and protein-enriched energy supplement for older persons dependent in activities of daily living: a randomised controlled trial. Aust. J. Physiother. 2006, 52:105-113.
137. Russell C.A., Elia M. Nutrition Screening Survey in the UK in 2008. A Report by the British Association for Parenteral and Enteral Nutrition (BAPEN) 2009, BAPEN, Redditch, UK.
138. Sattler F.R., Rajicic N., Mulligan K., Yarasheski K.E., Koletar S.L., Zolopa A., Alston Smith B., Bistrain B. Evaluation of high-protein supplementation in weight-stable HIV-positive subjects with a history of weight loss: a randomized, double-blind, multicenter trial. Am. J. Clin. Nutr. 2008, 88:1313-1321. ACTG 392 Study Team.
139. Saudny-Unterberger H., Martin J.G., Gray-Donald K. Impact of nutritional support on functional status during an acute exacerbation of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1997, 156:794-799.
140. Schurch M.A., Rizzoli R., Slosman D., Vadas L., Vergnaud P., Bonjour J.P. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture: a randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 1998, 128:801-809.
141. Schwenk A., Steuck H., Kremer G. Oral supplements as adjunctive treatment to nutritional counseling in malnourished HIV-infected patients: randomized controlled trial. Clin. Nutr. 1999, 18:371-374.
142. Seidner D.L., Lashner B.A., Brzezinski A., Banks P.L., Goldblum J., Fiocchi C., Katz J., Lichtenstein G.R., Anton P.A., Kam L.Y., Garleb K.A., DeMichele S.J. An oral supplement enriched with fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis: a randomized, controlled trial. Clin. Gastroenterol. Hepatol. 2005, 3:358-369.
143. Smedley F., Bowling T., James M., Stokes E., Goodger C., O'Connor O., Oldale C., Jones P., Silk D. Randomized clinical trial of the effects of preoperative and postoperative oral nutritional supplements on clinical course and cost of care. Br. J. Surg. 2004, 91:983-990.
144. Stableforth P.G. Supplement feeds and nitrogen and calorie balance following femoral neck fracture. Br. J. Surg. 1986, 73:651-655.
145. Steiner M.C., Barton R.L., Singh S.J., Morgan M.D.L. Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: a randomised controlled trial. Thorax 2003, 58:745-751.
146. Stratton R.J., Green C.J., Elia M. Disease-related Malnutrition: An Evidence-based Approach to Treatment 2003, Cabi Publishing, UKCABI Publishing, Oxford.
147. Stratton R.J., Ek A.C., Engfer M., Moore Z., Rigby P., Wolfe R., Elia M. Enteral nutritional support in prevention and treatment of pressure ulcers: a systematic review and meta-analysis. Ageing Res. Rev. 2005, 4:422-450.
148. Stratton R.J., Elia M. A review of reviews: a new look at the evidence for oral nutritional supplements in clinical practice. Clin. Nutr. Suppl. 2007, 2:5-23.
149. Sundell M.B., Cavanaugh K.L., Wu P., Shintani A., Hakim R.M., Ikizler T.A. Oral protein supplementation alone improves anabolism in a dose-dependent manner in chronic hemodialysis patients. J. Ren. Nutr. 2009, 19:412-421.
150. Tang Y.P., Li P.G., Kondo M., Ji H.P., Kou Y., Ou B. Effect of a mangosteen dietary supplement on human immune function: a randomized, double-blind, placebo-controlled trial. J. Med. Food 2009, 12:755-763.
151. Teixido-Planas J., Ortiz A., Coronel F., Montenegro J., Lopez-Menchero R., Ortiz R., Gomez C., Donate T. Oral protein-energy supplements in peritoneal dialysis: a multicenter study. Perit. Dial. Int. 2005, 25:163-172.
152. Tepaske R., te Velthuis H., Oudemans-van Straaten H.M., Bossuyt P.M.M., Schultz M.J., Eijsman L., Vroom M. Glycine does not add to the beneficial effects of preoperative oral immune-enhancing nutrition supplements in high-risk cardiac surgery patients. JPEN J. Parenter. Enteral Nutr. 2007, 31:173-180.
153. The Cochrane Collaboration Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [Updated September 2009] 2009, Available from www.cochrane-handbook.org.
154. Tidermark J., Ponzer S., Carlsson P., Soderqvist A., Brismar K., Tengstrand B., Cederholm T. Effects of protein-rich supplementation and nandrolone in lean elderly women with femoral neck fractures. Clin. Nutr. 2004, 23:587-596.
155. Tiengou L.E., Gloro R., Pouzoulet J., Bouhier K., Read M.H., Arnaud-Battandier F., Plaze J.M., Blaizot X., Dao T., Piquet M.A. Semi-elemental formula or polymeric formula: is there a better choice for enteral nutrition in acute pancreatitis? Randomized comparative study. JPEN. J. Parenter. Enteral Nutr. 2006, 30:1-5.
156. Tkatch L., Rapin C.H., Rizzoli R., Slosman D., Nydegger V., Vasey H., Bonjour J.P. Benefits of oral protein supplementation in elderly patients with fracture of the proximal femur. J. Am. Coll. Nutr. 1992, 11:519-525.
157. Verma S., Kirkwood B., Brown S., Giaffer M.H. Oral nutritional supplementation is effective in the maintenance of remission in Crohn's disease. Dig. Liver Dis. 2000, 32:769-774.
158. Volkert D., Hubsch S., Oster P., Schlierf G. Nutritional support and functional status in undernourished geriatric patients during hospitalization and 6-month follow-up. Aging (Milano) 1996, 8:386-395.
159. Waitzberg D.L., Caiaffa W.T., Correia M. Hospital malnutrition: the Brazilian national survey (IBRANUTRI): a study of 4000 patients. Nutrition 2001, 17:573-580.
160. WHO, 2007. Protein and Amino Acid Requirements in Human Nutrition. WHO Technical Report Series 935.
161. Williams C.M., Driver L.T., Older J., Dickerson J.W. A controlled trial of sip-feed supplements in elderly orthopaedic patients. Eur. J. Clin. Nutr. 1989, 43:267-274.
162. Witte M.B., Barbul A. Arginine physiology and its implication for wound healing. Wound Repair Regen. 2003, 11:419-423.
163. Woo J., HO S.C., Mak Y., Law L., Cheung A.A. Nutritional status of elderly patients during recovery from chest infection and the role of nutritional supplementation assessed by a prospective randomized single-blind trial. Age Ageing 1994, 23:40-48.
164. Wouters-Wesseling W., Slump E., Kleijer C.N., De Groot L.C., van Staveren W.A. Early nutritional supplementation immediately after diagnosis of infectious disease improves body weight in psychogeriatric nursing home residents. Aging Clin. Exp. Res. 2006, 18:70-74.
165. Wouters-Wesseling W., Van Hooijdonk C., Wagenaar L., Bindels J., de Groot L., Van Staveren W. The effect of a liquid nutrition supplement on body composition and physical functioning in elderly people. Clin. Nutr. 2003, 22:371-377.
166. Wouters-Wesseling W., Vos A.P., Van Hal M., De Groot L.C., van Staveren W.A., Bindels J.G. The effect of supplementation with an enriched drink on indices of immune function in frail elderly. J. Nutr. Health Aging 2005, 9:281-286.
167. Wouters-Wesseling W., Wouters A.E., Kleijer C.N., Bindels J.G., de Groot C.P., van Staveren W.A. Study of the effect of a liquid nutrition supplement on the nutritional status of psycho-geriatric nursing home patients. Eur. J. Clin. Nutr. 2002, 56:245-251.
168. Yamaguchi L.Y., Coulston A.M., Lu L.D., Dixon L.B., Craig L.D. Improvement in nutrient intake by elderly meals-on-wheels participants receiving a liquid nutrition supplement. Nutr. Today 1998, 33:37-44.
169. Young K.W., Greenwood C.E., van Reekum R., Binns M.A. Providing nutrition supplements to institutionalized seniors with probable Alzheimer's disease is least beneficial to those with low body weight status. J. Am. Geriatr. Soc. 2004, 52:1305-1312.