Macromolecular Co-Conjugates of Methotrexate and Ferrocene in the Chemotherapy of Cancer

Journal of Inorganic and Organometallic Polymers and Materials

Volumn 22, Issue 2, 2012, Pages 423-428

  Mufula, Alain I ^a   Aderibigbe, B A ^a   Neuse, Eberhard W ^a   Mukaya, Hembe E ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Amine; Carrier; Co conjugate; Conjugate; Coupling; Polyaspartamide; Polymer

Indexed keywords

CARRIER; CO-CONJUGATE; CONJUGATE; POLYASPARTAMIDES; POLYMER (SOLID);

AMINES; CHEMOTHERAPY; COUPLINGS; DISEASES; DRUG INTERACTIONS; FUNCTIONAL POLYMERS; IRON COMPOUNDS; MACROMOLECULES; ORGANIC ACIDS; ORGANOMETALLICS;

DRUG DOSAGE;

EID: 84857948719     PISSN: 15741443     EISSN: 15741451     Source Type: Journal    
DOI: 10.1007/s10904-011-9595-2     Document Type: Article

References (11)

1. E. W. Neuse, Synthetic Polymers as Drug-Delivery Vehicles in Medicine. (Hindawi Publishing Corporation, Cairo, 2008). doi: 10. 1155/2008/217573.
2. D. D. N'da, Synthesis of Methotrexate and Ferrocene Conjugates as Potential Anticancer Agents, PhD Dissertation. (School of Chemistry, Cambridge, 2004).
3. A. A. Simenela, E. A. Morozovaa, L. V. Snegura, S. I. Zykovaa, V. V. Kachalab, L. A. Ostrovskayac, N. V. Bluchterovac, M. M. Fominac, Simple Route to Ferrocenylalkyl Nucleobases. Antitumor Activity In Vivo, Appl. Organomet. Chem. 23, 219 (2009).
4. E. W. Neuse, in Macromolecules Containing Metal and Metal-Like Elements: Biomedical Applications, vol. 3, ed. by A. S. Abd-El-Aziz, C. E. Carraher, C. U. Pittman, J. E. Sheats, M. Zeldin, (Wiley, New-York, 2004), Chap. 6.
5. M. G. Meirim, Polymer Conjugated Anticancer Drugs, M. Sc. Dissertation. (School of Chemistry, Wits University, Cambridge, 2002).
6. L. L. Komane, H. E. Mukaya, E. W. Neuse, C. E. J. van Rensburg, Macromolecular antiproliferative agents featuring dicarboxylato-chelated platinum. J. Inorg. Organometal. Polym. Mater. 18, 111-123 (2008). doi: 10. 1007/s10904-007-9175-7.
7. A. I. Mufula, E. W. Neuse, Macromolecular carriers for methotrexate and ferrocene in cancer chemotherapy, J. Inorg. Organomet. Polym. Mat. (2011). doi: 10. 1007/s10904-011-9471-0.
8. R. G. W. Anderson, B. A. Kamen, K. G. Rothberg, Science 225, 410-411 (1992).
9. A. I. Mufula, Macromolecular Derivatives of Methotrexate and Ferrocene as Potential Prodrugs in Cancer Chemotherapy, MSc. Dissertation. (School of Chemistry, Wits University, Cambridge 2010).
10. A. U. Buzdar, G. N. Hortobagyi, Sem. Oncol. 26, 21-27 (1999).
11. A. I. Mufula, E. W. Neuse, Macromolecular conjugates for methotrexate, ferrocene and platinum in cancer chemotherapy, J. Inorg. Organomet. Polym. Mat. (2011) doi: 10. 1007/s10904-011-9497-3.