Vascular endothelial growth factor receptor-2 in macular oedema with retinal vein occlusion

Ophthalmic Research

Volumn 48, Issue 1, 2012, Pages 56-58

  Noma, Hidetaka ^a   Funatsu, Hideharu ^a   Mimura, Tatsuya ^b   Eguchi, Shuichiro ^c  

^a Tokyo Women s Medical University   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Eguchi Eye Hospital   (Japan)

Author keywords

Macular oedema; Retinal vein occlusion; Soluble vascular endothelial growth factor receptor 2; Vascular endothelial growth factor

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ARTICLE; BRANCH RETINAL VEIN OCCLUSION; CLINICAL ARTICLE; DISEASE SEVERITY; HUMAN; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RETINA MACULA EDEMA; VASCULAR ENDOTHELIUM; VITREORETINAL SURGERY; VITREOUS BODY;

AGED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MACULAR EDEMA; MALE; RETINAL VEIN OCCLUSION; TOMOGRAPHY, OPTICAL COHERENCE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VITRECTOMY; VITREOUS BODY;

EID: 84857935079     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000336020     Document Type: Article

References (9)

1. Kaneda S, Miyazaki D, Sasaki S, Yakura K, Terasaka Y, Miyake K, Ikeda Y, Funakoshi T, Baba T, Yamasaki A, Inoue Y: Multivariate analyses of inflammatory cytokines in eyes with branch retinal vein occlusion: relationships to bevacizumab treatment. Invest Ophthalmol Vis Sci 2011; 52: 2982-2988.
2. Noma H, Funatsu H, Mimura T, Eguchi S, Hori S: Soluble vascular endothelial growth factor receptor-2 and inflammatory factors in macular edema with branch retinal vein occlusion. Am J Ophthalmol 2011; 152: 669-677.e1.
3. Noma H, Funatsu H, Mimura T, Eguchi S, Shimada K: Role of soluble vascular endothelial growth factor receptor-2 in macular oedema with central retinal vein occlusion. Br J Ophthalmol 2011; 95: 788-792.
4. Olsson AK, Dimberg A, Kreuger J, Claesson- Welsh L: VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 2006; 7: 359-371.
5. Wen Y, Edelman JL, Kang T, Zeng N, Sachs G: Two functional forms of vascular endothelial growth factor receptor-2/Flk-1 mRNA are expressed in normal rat retina. J Biol Chem 1998; 273: 2090-2097.
6. Agostini H, Boden K, Unsold A, Martin G, Hansen L, Fiedler U, Esser N, Marme D: A single local injection of recombinant VEGF receptor 2 but not of Tie2 inhibits retinal neovascularization in the mouse. Curr Eye Res 2005; 30: 249-257.
7. Swendeman S, Mendelson K, Weskamp G, Horiuchi K, Deutsch U, Scherle P, Hooper A, Rafii S, Blobel CP: VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling. Circ Res 2008; 103: 916-918.
8. Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J: Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med 2009; 15: 1023-1030.
9. Lorquet S, Berndt S, Blacher S, Gengoux E, Peulen O, Maquoi E, Noel A, Foidart JM, Munaut C, Pequeux C. Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment. FASEB J 2010; 24: 3782-3795.