Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: An autoradiographic study

Brain Research Bulletin

Volumn 87, Issue 4-5, 2012, Pages 406-412

  Kovačević, Tomislav ^a,b   Skelin, Ivan ^a,d   Minuzzi, Luciano ^c   Rosa Neto, Pedro ^c   Diksic, Mirko ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b JOSIP JURAJ STROSSMAYER UNIVERSITY OF OSIJEK   (Croatia)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF LETHBRIDGE   (Canada)

Author keywords

Depression model; Flinders Resistant Line; Flinders Sensitive Line; MGluR5 receptors; Sprague Dawley rats

Indexed keywords

METABOTROPIC RECEPTOR 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN LEVEL; BRAIN RADIOGRAPHY; CONTROLLED STUDY; DENSITY; DEPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RAT;

ANIMALS; AUTORADIOGRAPHY; BRAIN; DEPRESSION; DISEASE MODELS, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 84857921675     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2012.01.010     Document Type: Article

References (71)

1. Altamura C.A., Mauri M.C., Ferrara A., Moro A.R., D'Andrea G., Zamberlan F. Plasma and platelet excitatory amino acids in psychiatric disorders. Am. J. Psychiatry 1993, 150:1731-1733.
2. Ametamey S.M., Treyer V., Streffer J., Wyss M.T., Schmidt M., Blagoev M., Hintermann S., Auberson Y., Gasparini F., Fischer U.C., Buck A. Human PET studies of metabotropic glutamate receptor subtype 5 with 11C-ABP688. J. Nucl. Med. 2007, 48:247-252.
3. Auer D.P., Putz B., Kraft E., Lipinski B., Schill J., Holsboer F. Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biol. Psychiatry 2000, 47:305-313.
4. Barichello T., Dos Santos I., Savi G.D., Simoes L.R., Generoso J.S., Comim C.M., Sachs D., Teixeira A.L., Quevedo J. Depressive-like-behavior and proinflamatory interleukine levels in the brain of rats submitted to pneumococcal meningitis. Brain Res. Bull. 2010, 82:243-246.
5. Beneyto M., Kristiansen L.V., Oni-Orisan A., McCullumsmith R.E., Meador-Woodruff J.H. Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders. Neuropsychopharmacology 2007, 32:1888-1902.
6. Bjornebekk A., Mathe A.A., Brene S. The antidepressant effect of running is associated with increased hippocampal cell proliferation. Int. J. Neuropsychopharmacol. 2005, 8:357-368.
7. Block W., Traber F., von Widdern O., Metten M., Schild H., Maier W., Zobel A., Jessen F. Proton MR spectroscopy of the hippocampus at 3T in patients with unipolar major depressive disorder: correlates and predictors of treatment response. Int. J. Neuropsychopharmacol. 2009, 12:415-422.
8. Broberger C. Brain regulation of food intake and appetite: molecules and networks. J. Intern. Med. 2005, 258:301-327.
9. Carroll F.I. Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction. Ann. N. Y. Acad. Sci. 2008, 1141:221-232.
10. Charney D.S. Monoamine dysfunction and the pathophysiology and treatment of depression. J. Clin. Psychiatry 1998, 59(Suppl. 14):11-14.
11. Chen F., Madsen T.M., Wegener G., Nyengaard J.R. Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression. Hippocampus 2010, 20:1376-1384.
12. Chiamulera C., Epping-Jordan M.P., Zocchi A., Marcon C., Cottiny C., Tacconi S., Corsi M., Orzi F., Conquet F. Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat. Neurosci. 2001, 4:873-874.
13. Clark L., Chamberlain S.R., Sahakian B.J. Neurocognitive mechanisms in depression: implications for treatment. Annu. Rev. Neurosci. 2009, 32:57-74.
14. Cleva R.M., Olive M.F. Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders. Molecules 2011, 16:2097-2106.
15. Deschwanden A., Karolewicz B., Feyissa A.M., Treyer V., Ametamey S.M., Johayem A., Burger C., Auberson Y.P., Sovago J., Stockmeier C.A., Buck A., Hasler G. Reduced metabotropic glutamate receptor 5 density in major depression determined by [11C]ABP688 PET and Postmortem Study. Am. J. Psychiatry 2011, 168:727-734.
16. Deschwanden A., Karolewicz B., Feyissa A.M., Treyer V., Ametamey S.M., Johayem A., Burger C., Auberson Y.P., Sovago J., Stockmeier C.A., Buck A., Hasler G. Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study. Am. J. Psychiatry 2011, 168:727-734.
17. Dhami G.K., Ferguson S.S. Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis. Pharmacol. Ther. 2006, 111:260-271.
18. Dremencov E., Newman M.E., Kinor N., Blatman-Jan G., Schindler C.J., Overstreet D.H., Yadid G. Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment. Neuropharmacology 2005, 48:34-42.
19. Enz R. Metabotropic glutamate receptors and interacting proteins: evolving drug target. Curr. Drug Targets 2011.
20. Eriksson T.M., Delagrange P., Spedding M., Popoli M., Mathe A.A., Ogren S.O., Svenningsson P. Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration. Mol. Psychiatry 2011.
21. Fagergren P., Overstreet D.H., Goiny M., Hurd Y.L. Blunted response to cocaine in the Flinders hypercholinergic animal model of depression. Neuroscience 2005, 132:1159-1171.
22. Friedman A., Friedman Y., Dremencov E., Yadid G. VTA dopamine neuron bursting is altered in an animal model of depression and corrected by desipramine. J. Mol. Neurosci. 2008, 34:201-209.
23. Hascup K.N., Hascup E.R., Stephens M.L., Glaser P.E., Yoshitake T., Mathe A.A., Gerhardt G.A., Kehr J. Resting glutamate levels and rapid glutamate transients in the prefrontal cortex of the Flinders Sensitive Line rat: a genetic rodent model of depression. Neuropsychopharmacology 2011, 36:1769-1777.
24. Hasegawa S., Nishi K., Watanabe A., Overstreet D.H., Diksic M. Brain 5-HT synthesis in the Flinders Sensitive Line rat model of depression: an autoradiographic study. Neurochem. Int. 2006, 48:358-366.
25. Hashimoto K. Emerging role of glutamate in the pathophysiology of major depressive disorder. Brain Res. Rev. 2009, 61:105-123.
26. Heidinger V., Manzerra P., Wang X.Q., Strasser U., Yu S.P., Choi D.W., Behrens M.M. Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J. Neurosci. 2002, 22:5452-5461.
27. Hintermann S., Vranesic I., Allgeier H., Brulisauer A., Hoyer D., Lemaire M., Moenius T., Urwyler S., Whitebread S., Gasparini F., Auberson Y.P. ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg. Med. Chem. 2007, 15:903-914.
28. Husum H., Aznar S., Hoyer-Hansen S., Larsen M.H., Mikkelsen J.D., Moller A., Mathe A.A., Wortwein G. Exacerbated loss of cell survival, neuropeptide Y-immunoreactive (IR) cells, and serotonin-IR fiber lengths in the dorsal hippocampus of the aged flinders sensitive line depressed rat: implications for the pathophysiology of depression?. J. Neurosci. Res. 2006, 84:1292-1302.
29. Kanemaru K., Diksic M. The Flinders Sensitive Line of rats, a rat model of depression, has elevated brain glucose utilization when compared to normal rats and the Flinders Resistant Line of rats. Neurochem. Int. 2009, 55:655-661.
30. Kanemaru K., Hasegawa S., Nishi K., Diksic M. Acute citalopram has different effects on regional 5-HT synthesis in FSL, FRL, and SDP rats: an autoradiographic evaluation. Brain Res. Bull. 2008, 77:214-220.
31. Kanemaru K., Nishi K., Hasegawa S., Diksic M. Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats. Neurochem. Int. 2009, 54:363-371.
32. Karolewicz B., Johnson L., Szebeni K., Stockmeier C.A., Ordway G.A. Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics. J. Psychiatr. Res. 2008, 42:348-355.
33. Keller M.B., Lavori P.W., Rice J., Coryell W., Hirschfeld R.M. The persistent risk of chronicity in recurrent episodes of nonbipolar major depressive disorder: a prospective follow-up. Am. J. Psychiatry 1986, 143:24-28.
34. Kenny P.J., Paterson N.E., Boutrel B., Semenova S., Harrison A.A., Gasparini F., Koob G.F., Skoubis P.D., Markou A. Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Ann. N. Y. Acad. Sci. 2003, 1003:415-418.
35. Kokras N., Antoniou K., Polissidis A., Papadopoulou-Daifoti Z. Antidepressants induce regionally discrete, sex-dependent changes in brain's glutamate content. Neurosci. Lett. 2009, 464:98-102.
36. Kovacevic T., Skelin I., Diksic M. Chronic fluoxetine treatment has a larger effect on the density of a serotonin transporter in the Flinders Sensitive Line (FSL) rat model of depression than in normal rats. Synapse 2010, 64:231-240.
37. Kuhn R., Pagano A., Stoehr N., Vranesic I., Flor P.J., Lingenhohl K., Spooren W., Gentsch C., Vassout A., Pilc A., Gasparini F. In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article. Amino Acids 2002, 23:207-211.
38. Liberatore G.T., Wong J.Y., Krenus D., Jeffreys B.J., Porritt M.J., Howells D.W. Tissue fixation prevents contamination of tritium-sensitive storage phosphor imaging plates. Biotechniques 1999, 26:432-434.
39. Lorenc-Koci E., Smialowska M., Antkiewicz-Michaluk L., Golembiowska K., Bajkowska M., Wolfarth S. Effect of acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline on muscle tone, metabolism of dopamine in the striatum and tyrosine hydroxylase immunocytochemistry in the substantia nigra, in rats. Neuroscience 2000, 95:1049-1059.
40. Machado-Vieira R., Salvadore G., Ibrahim L.A., Diaz-Granados N., Zarate C.A. Targeting glutamatergic signaling for the development of novel therapeutics for mood disorders. Curr. Pharm. Des. 2009, 15:1595-1611.
41. Maes M., Verkerk R., Vandoolaeghe E., Lin A., Scharpe S. Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity. Acta Psychiatr. Scand. 1998, 97:302-308.
42. Matrisciano F., Caruso A., Orlando R., Marchiafava M., Bruno V., Battaglia G., Gruber S.H., Melchiorri D., Tatarelli R., Girardi P., Mathe A.A., Nicoletti F. Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats. Neuropharmacology 2008, 55:525-531.
43. Mattson M.P. Glutamate and neurotrophic factors in neuronal plasticity and disease. Ann. N. Y. Acad. Sci. 2008, 1144:97-112.
44. Moutsimilli L., Farley S., Dumas S., El Mestikawy S., Giros B., Tzavara E.T. Selective cortical VGLUT1 increase as a marker for antidepressant activity. Neuropharmacology 2005, 49:890-900.
45. Nishi K., Kanemaru K., Diksic M. A genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT(1A) receptors, but a higher density of 5-HT(1B) receptors, compared to control rats. Neurochem. Int. 2009, 54:299-307.
46. Nishi K., Kanemaru K., Hasegawa S., Watanabe A., Diksic M. Both acute and chronic buspirone treatments have different effects on regional 5-HT synthesis in Flinders Sensitive Line rats (a rat model of depression) than in control rats. Neurochem. Int. 2009, 54:205-214.
47. Orzel-Gryglewska J., Kusmierczak M., Jurkowlaniec E. Involvement of GABAergic transmission in the midbrain ventral tegmental area in the regulation of hippocampal theta rhythm. Brain Res. Bull. 2010, 83:310-320.
48. Overstreet D.H. Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists. Behav. Genet. 2002, 32:335-348.
49. Overstreet D.H., Friedman E., Mathe A.A., Yadid G. The Flinders Sensitive Line rat: a selectively bred putative animal model of depression. Neurosci. Biobehav. Rev. 2005, 29:739-759.
50. Palucha A., Pilc A. Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs. Pharmacol. Ther. 2007, 115:116-147.
51. Paterson N.E., Semenova S., Gasparini F., Markou A. The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology (Berl.) 2003, 167:257-264.
52. Paul I.A., Layer R.T., Skolnick P., Nowak G. Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine. Eur. J. Pharmacol. 1993, 247:305-311.
53. Paxinos G., Watson C. The Rat Brain Atlas in Stereotaxic Coordinates 1997, Academic Press, New York. Compact third ed.
54. Pfleiderer B., Michael N., Erfurth A., Ohrmann P., Hohmann U., Wolgast M., Fiebich M., Arolt V., Heindel W. Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients. Psychiatry Res. 2003, 122:185-192.
55. Pilc A., Klodzinska A., Branski P., Nowak G., Palucha A., Szewczyk B., Tatarczynska E., Chojnacka-Wojcik E., Wieronska J.M. Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats. Neuropharmacology 2002, 43:181-187.
56. Popik P., Kos T., Zhang Y., Bisaga A. Memantine reduces consumption of highly palatable food in a rat model of binge eating. Amino Acids 2011, 40:477-485.
57. Popik P., Wrobel M., Rygula R., Bisaga A., Bespalov A.Y. Effects of memantine, an NMDA receptor antagonist, on place preference conditioned with drug and nondrug reinforcers in mice. Behav. Pharmacol. 2003, 14:237-244.
58. Quan M., Zheng C., Zhang N., Han D., Tian Y., Zhang T., Yang Z. Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression. Brain Res. Bull. 2011, 85:109-116.
59. Regier D.A., Farmer M.E., Rae D.S., Locke B.Z., Keith S.J., Judd L.L., Goodwin F.K. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 1990, 264:2511-2518.
60. Reus G.Z., Stringari R.B., Kirsch T.R., Fries G.R., Kapczinski F., Roesler R., Quevedo J. Neurochemical and behavioural effects of acute and chronic memantine administration in rats: further support for NMDA as a new pharmacological target for the treatment of depression?. Brain Res. Bull. 2010, 81:585-589.
61. Romano C., Sesma M.A., McDonald C.T., O'Malley K., Van den Pol A.N., Olney J.W. Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. J. Comp. Neurol. 1995, 355:455-469.
62. Salamone J.D., Cousins M.S., Snyder B.J. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis. Neurosci. Biobehav. Rev. 1997, 21:341-359.
63. Salari A.A., Enayati M., Hosseini M.H., Shahi H.R., Saki G. Maternal infection during late pregnancy increases anxiety- and depression-like behaviors with increasing age in male offspring. Brain Res. Bull. 2011.
64. Shayit M., Yadid G., Overstreet D.H., Weller A. 5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression. Brain Res. 2003, 980:100-108.
65. Spooren W., Gasparini F. mGlu5 receptor antagonists: a novel class of anxiolytics?. Drug News Perspect. 2004, 17:251-257.
66. Vazdarjanova A., McNaughton B.L., Barnes C.A., Worley P.F., Guzowski J.F. Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. J. Neurosci. 2002, 22:10067-10071.
67. Venero J.L., Santiago M., Tomas-Camardiel M., Matarredona E.R., Cano J., Machado A. DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury. Neuroscience 2002, 113:857-869.
68. Wieronska J.M., Smialowska M., Branski P., Gasparini F., Klodzinska A., Szewczyk B., Palucha A., Chojnacka-Wojcik E., Pilc A. In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling. Neuropsychopharmacology 2004, 29:514-521.
69. Wyss M.T., Ametamey S.M., Treyer V., Bettio A., Blagoev M., Kessler L.J., Burger C., Weber B., Schmidt M., Gasparini F., Buck A. Quantitative evaluation of 11C-ABP688 as PET ligand for the measurement of the metabotropic glutamate receptor subtype 5 using autoradiographic studies and a beta-scintillator. Neuroimage 2007, 35:1086-1092.
70. Zangen A., Overstreet D.H., Yadid G. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. J. Neurochem. 1997, 69:2477-2483.
71. Sanacora G., Gueorguieva R., Epperson C.N., Wu Y.T., Appel M., Rothman D.L., Krystal J.H., Mason G.F. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch. Gen. Psychiatry 2004, 61:705-713.