Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 6, 2012, Pages 2271-2278

  Hanrahan, Patrick ^a   Bell, James ^a   Bottomley, Gillian ^a   Bradley, Stuart ^a   Clarke, Phillip ^a   Curtis, Eleanor ^a   Davis, Susan ^a   Dawson, Graham ^a   Horswill, James ^a   Keily, John ^a   Moore, Gary ^a   Rasamison, Chrystelle ^a   Bloxham, Jason ^a  

^a Prosidion Ltd   (United Kingdom)

Author keywords

Azaquinazolinone; Diabetes; Ghrelin; LipE; Obesity; Prosidion

Indexed keywords

AZAQUINAZOLINONE DERIVATIVE; GHRELIN RECEPTOR; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; MALE; MAXIMUM PLASMA CONCENTRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; RAT;

ADMINISTRATION, ORAL; ANIMALS; AZA COMPOUNDS; BIOLOGICAL AVAILABILITY; DIABETES MELLITUS, TYPE 2; DRUG DESIGN; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYPOGLYCEMIC AGENTS; KINETICS; MALE; OBESITY; QUINAZOLINONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GHRELIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857914389     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.078     Document Type: Article

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