Does the presence of 3-epi-25OHD 3 affect the routine measurement of vitamin D using liquid chromatography tandem mass spectrometry?

Clinical Chemistry and Laboratory Medicine

Volumn 50, Issue 1, 2012, Pages 181-183

  Keevil, Brian ^a  

^a MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

3 epi 25OHD 3; Liquid chromatography tandem mass spectrometry (LC MS MS) Vitamin D

Indexed keywords

25 HYDROXYERGOCALCIFEROL; 3 EPI 25 DIHYDROXYVITAMIN D3; COLECALCIFEROL DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN D;

ACCURACY; ADULT; ANALYTIC METHOD; CHILD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFANT; LETTER; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; NEWBORN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

25-HYDROXYVITAMIN D 2; CHROMATOGRAPHY, LIQUID; CLINICAL CHEMISTRY TESTS; HUMANS; TANDEM MASS SPECTROMETRY; VITAMIN D;

EID: 84857889828     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.755     Document Type: Letter

References (4)

1. Singh RJ, Taylor RL, Reddy GS, Grebe SK. C3-epimers can account for a significant proportion of total circulating 25-hydroxy vitamin D in infants, complicating accurate measurement and interpretation of vitamin D status. J Clin Endocrinol Metab 2006;91:3055-61. (Pubitemid 44271755)
2. 3 in serum of infants and adults. Clin Chem Lab Med 2011;49:253-6.
3. 3 using UPLC/MS/MS in the adult population. Abstract, The Association for Mass Spectrometry Application to the Clinical Lab 2011, San Diego, Poster No. 9 (7th Feb 2011).
4. 3: its synthesis, biological activity and crystal structure with its receptor. PLoS One 2011 Mar 31;6: e18124.