Cartilage defect regeneration by ex vivo engineered autologous microtissue - Preliminary results

In Vivo

Volumn 26, Issue 2, 2012, Pages 251-257

  Meyer, Ulrich ^a   Wiesmann, Hans Peter ^b   Libera, Jeanette ^c   Depprich, Rita ^a   Naujoks, Christian ^a   Handschel, Jörg ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c codon AG ^*  (Germany)

Author keywords

Cartilage; Microspheres; Scaffold free; Tissue engineering; Tissue repair

Indexed keywords

MICROSPHERE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CARTILAGE INJURY; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MINIPIG; NONHUMAN; SYNOVIUM; TISSUE ENGINEERING; TISSUE REGENERATION; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84857879645     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Buckwalter JA and Lane NE: Athletics and osteoarthritis. Am J Sports Med 25(6): 873-881, 1997. (Pubitemid 27508428)
2. Gold GE, Bergman AG, Pauly JM, Lang P, Butts RK, Beaulieu CF, Hargreaves B, Frank L, Boutin RD, Macovski A and Resnick D: Magnetic resonance imaging of knee cartilage repair. Top Magn Reson Imaging 9(6): 377-392, 1998. (Pubitemid 29031117)
3. Saxon L, Finch C and Bass S: Sports participation, sports injuries and osteoarthritis: Implications for prevention. Sports Med 28(2): 123-135, 1999. (Pubitemid 29425544)
4. Minas T and Nehrer S: Current concepts in the treatment of articular cartilage defects. Orthopedics 20(6): 525-538, 1997. (Pubitemid 27255622)
5. Cole BJ and Lee SJ: Complex knee reconstruction: Articular cartilage treatment options. Arthroscopy 19(Suppl 1): 1-10, 2003. (Pubitemid 37531933)
6. Ghivizzani SC, Oligino TJ, Robbins PD and Evans CH: Cartilage injury and repair. Phys Med Rehabil Clin N Am 11(2): 289-307, vi, 2000.
7. Mayhew TA, Williams GR, Senica MA, Kuniholm G and Du Moulin GC: Validation of a quality assurance program for autologous cultured chondrocyte implantation. Tissue Eng 4(3): 325-334, 1998. (Pubitemid 28465173)
8. Gillogly SD, Voight M and Blackburn T: Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation. J Orthop Sports Phys Ther 28(4): 241-251, 1998. (Pubitemid 28470980)
9. Peterson L, Minas T, Brittberg M, Nilsson A and Sjogren-Jansson EandLindahl A: Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res 374: 212-234, 2000.
10. Breinan HA, Martin SD, Hsu HP and Spector M: Healing of canine articular cartilage defects treated with microfracture, a type-II collagen matrix, or cultured autologous chondrocytes. J Orthop Res 18(5): 781-789, 2000.
11. Breinan HA, Minas T, Hsu HP, Nehrer S, Shortkroff S and Spector M: Autologous chondrocyte implantation in a canine model: Change in composition of reparative tissue with time. J Orthop Res 19(3): 482-492, 2001. (Pubitemid 32472020)
12. Brittberg M, Nilsson A, Lindahl A, Ohlsson C and Peterson L: Rabbit articular cartilage defects treated with autologous cultured chondrocytes. Clin Orthop Relat Res 326: 270-283, 1996. (Pubitemid 26147776)
13. Chu CR, Coutts RD, Yoshioka M, Harwood FL, Monosov AZ and Amiel D: Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): A tissue-engineering study. J Biomed Mater Res 29(9): 1147-1154, 1995.
14. Frenkel SR, Toolan B, Menche D, Pitman MI and Pachence JM: Chondrocyte transplantation using a collagen bilayer matrix for cartilage repair. J Bone Joint Surg Br 79(5): 831-836, 1997. (Pubitemid 27434509)
15. Sims CD, Butler PE, Cao YL, Casanova R, Randolph MA, Black A, Vacanti CA and Yaremchuk MJ: Tissue engineered neocartilage using plasma derived polymer substrates and chondrocytes. Plast Reconstr Surg 101(6): 1580-1585, 1998. (Pubitemid 28234664)
16. Temenoff JS and Mikos AG: Review: Tissue engineering for regeneration of articular cartilage. Biomaterials 21(5): 431-440, 2000. (Pubitemid 30067578)
17. Woodfield TB, Bezemer JM, Pieper JS, Van Blitterswijk CA and Riesle J: Scaffolds for tissue engineering of cartilage. Crit Rev Eukaryot Gene Expr 12(3): 209-236, 2002. (Pubitemid 37045852)
18. Lee CR, Breinan HA, Nehrer S and Spector M: Articular cartilage chondrocytes in type I and type II collagen-GAG matrices exhibit contractile behavior in vitro. Tissue Eng 6(5): 555-565, 2000.
19. Johnstone B and Yoo JU: Autologous mesenchymal progenitor cells in articular cartilage repair. Clin Orthop Relat Res 367 Suppl: S156-162, 1999. (Pubitemid 29501497)
20. Handschel JG, Depprich RA, Kubler NR, Wiesmann HP, Ommerborn M and Meyer U: Prospects of micromass culture technology in tissue engineering. Head Face Med 3: 4, 2007.
21. Langenbach F, Berr K, Naujoks C, Hollinger A, Kelz M, Depprich R, Kübler N, Meyer U, Wiesmann H-P, Kögler G and Handschel J: Generation and differentiation of microtissues from multipotent precursor cells for use in tissue engineering. Nat Protoc 6(11): 1726-35, 2011.
22. Anderer U and Libera J: In vitro engineering of human autogenous cartilage. J Bone Miner Res 17(8): 1420-1429, 2002. (Pubitemid 34803826)
23. Hunziker EB and Driesang IM: Functional barrier principle for growth-factor-based articular cartilage repair. Osteoarthritis Cartilage 11(5): 320-327, 2003. (Pubitemid 36621841)
24. Meyer U, Buchter A, Hohoff A, Stoffels E, Szuwart T, Runte C, Dirksen D and Wiesmann HP: Image-based extracorporeal tissue engineering of individualized bone constructs. Int J Oral Maxillofac Implants 20(6): 882-890, 2005. (Pubitemid 43104466)
25. Freed LE, Grande DA, Lingbin Z, Emmanual J, Marquis JC and Langer R: Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds. J Biomed Mater Res 28(8): 891-899, 1994. (Pubitemid 24237852)
26. Sittinger M, Reitzel D, Dauner M, Hierlemann H, Hammer C, Kastenbauer E, Planck H, Burmester GR and Bujia J: Resorbable polyesters in cartilage engineering: Affinity and biocompatibility of polymer fiber structures to chondrocytes. J Biomed Mater Res 33(2): 57-63, 1996. (Pubitemid 26170805)
27. Handschel J, Naujoks C, Langenbach F, Berr K, Depprich RA, Ommerborn MA, Kubier NR, Brinkmann M, Kogler G and Meyer U: Comparison of ectopic bone formation of embryonic stem cells and cord blood stem cells in vivo. Tissue Eng Part A 16(8): 2475-2483, 2010.
28. Langenbach F, Naujoks C, Kersten-Thiele PV, Berr K, Depprich RA, Kubler NR, Kogler G and Handschel J: Osteogenic differentiation influences stem cell migration out of scaffold-free microspheres. Tissue Eng Part A 16(2): 759-766, 2010.
29. Van Der Kraan PM, Buma P, Van Kuppevelt T and Van Den Berg WB: Interaction of chondrocytes, extracellular matrix and growth factors: Relevance for articular cartilage tissue engineering. Osteoarthritis Cartilage 10(8): 631-637, 2002. (Pubitemid 34993949)
30. Rahfoth B, Weisser J, Sternkopf F, Aigner T, Von Der Mark K and Brauer R: Transplantation of allograft chondrocytes embedded in agarose gel into cartilage defects of rabbits. Osteoarthritis Cartilage 6(1): 50-65, 1998. (Pubitemid 28160884)
31. Benya PD and Shaffer JD: Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30(1): 215-224, 1982. (Pubitemid 13237099)
32. Bonaventure J, Kadhom N, Cohen-Solal L, Ng KH, Bourguignon J, Lasselin C and Freisinger P: Reexpression of cartilage-specific genes by dedifferentiated human articular chondrocytes cultured in alginate beads. Exp Cell Res 212(1): 97-104, 1994. (Pubitemid 24167363)
33. Grande DA, Pitman MI, Peterson L, Menche D and Klein M: The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantation. J Orthop Res 7(2): 208-218, 1989. (Pubitemid 19071033)
34. Hunziker EB: Biologic repair of articular cartilage. Defect models in experimental animals and matrix requirements. Clin Orthop Relat Res 367 Suppl: S135-146, 1999.
35. Ochi M, Uchio Y, Tobita M and Kuriwaka M: Current concepts in tissue engineering technique for repair of cartilage defect. Artif Organs 25(3): 172-179, 2001. (Pubitemid 32852964)
36. Frenkel SR and Di Cesare PE: Degradation and repair of articular cartilage. Front Biosci 4: D671-685, 1999.
37. Reinholz GG, Lu L, Saris DB, Yaszemski MJ and O'driscoll SW: Animal models for cartilage reconstruction. Biomaterials 25(9): 1511-1521, 2004.
38. Fundamentals of tissue engineering and regenerative medicine. Meyer U, Meyer T, Handschel JandWiesmann H-P (eds.). New York, Springer Verlag: 2009.
39. Mainil-Varlet P, Rieser F, Grogan S, Mueller W, Saager C and Jakob RP: Articular cartilage repair using a tissue-engineered cartilage-like implant: An animal study. Osteoarthritis Cartilage 9(Suppl A): S6-15, 2001.
40. Schubert T, Anders S, Neumann E, Scholmerich J, Hofstadter F, Grifka J, Muller-Ladner U, Libera J and Schedel J: Long-term effects of chondrospheres on cartilage lesions in an autologous chondrocyte implantation model as investigated in the scid mouse model. Int J Mol Med 23(4): 455-460, 2009.
41. Winter A, Breit S, Parsch D, Benz K, Steck E, Hauner H, Weber RM, Ewerbeck V and Richter W: Cartilage-like gene expression in differentiated human stem cell spheroids: A comparison of bone marrow-derived and adipose tissue-derived stromal cells. Arthritis Rheum 48(2): 418-429, 2003. (Pubitemid 36278011)
42. Lee CR, Grodzinsky AJ, Hsu HP and Spector M: Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model. J Orthop Res 21(2): 272-281, 2003. (Pubitemid 36322547)