Suppression of pre adipocyte differentiation and promotion of adipocyte death by anti-HIV drugs

In Vivo

Volumn 26, Issue 2, 2012, Pages 287-291

  Manente, Lucrezia ^a   Lucariello, Angela ^a   Costanzo, Carmelina ^a   Viglietti, Rosaria ^b   Parrella, Giovanni ^b   Parrella, Roberto ^b   Gargiulo, Miriam ^b   De Luca, Antonio ^a   Chirianni, Antonio ^b   Esposito, Vincenzo ^b  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b AO Dei Colli Hospital for Infectious Diseases D Cotugno   (Italy)

Author keywords

Adipocyte differentiation; Antiretroviral therapies; Efavirenz; HAART; HIV infection; Lipodystrophy; Metabolic syndrome; Oxidative stress; Saquinavir; Stavudine

Indexed keywords

AMPRENAVIR; COPPER ZINC SUPEROXIDE DISMUTASE; EFAVIRENZ; HEME OXYGENASE 1; INDINAVIR; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SAQUINAVIR; STAVUDINE;

ADIPOCYTE; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROADIPOCYTE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

EID: 84857874294     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Hengel RL, Watts NB and Lennox JL: Benign symmetric lipomatosis associated with protease inhibitors. Lancet 352: 319-320, 1998.
2. Carr A, Samaras K, Burton S, Law M, Freund J, Chisholm DJ and Cooper DA: A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 12: F51-F58, 1998. (Pubitemid 28190689)
3. Miller KD, Jones E, Yanovski JA, Shankar R, Feuerstein I and Falloon J: Visceral abdominal-fat accumulation associated with use of indinavir. Lancet 351: 871-875, 1998. (Pubitemid 28121176)
4. Yanovski JA, Miller KD, Kino T, Friedman TC, Chrousos GP, Tsigos C and Fallon J: Endocrine and metabolic evaluation of human immunodeficiency virus-infected patients with evidence of protease inhibitor-associated lipodystrophy. J Clin Endocrinol Metab 84: 1925-1931, 1999. (Pubitemid 30647011)
5. Dube MP, Johnson DL, Currier JS and Leedom JM: Protease inhibitor-associated hyperglycaemia. Lancet 350: 713-714, 1997. (Pubitemid 127739261)
6. Eastone JA and Decker CF: New-onset diabetes mellitus associated with use of protease inhibitor. Ann Intern Med 127: 948, 1997. (Pubitemid 27490630)
7. Walli R, Herfort O, Michl GM, Demant T, Jager H, Dieterle C, Bogner JR, Landgraf R and Goebel FD: Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients. AIDS 12: F167-F173, 1998. (Pubitemid 28479266)
8. Mondal D, Pradhan L, Ali M and Agrawal KC: HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells: exacerbation by inflammatory cytokines and amelioration by antioxidants. Cardiovasc Toxicol 4: 287-302, 2004. (Pubitemid 39382991)
9. Vincent S, Tourniaire F, El Yazidi CM, Compe E, Manches O, Plannels R and Roche R: Nelfmavir induces necrosis of 3T3F44-2A adipocytes by oxidative stress. J Acquir Immune Defic Syndr 37: 1556-1562, 2004. (Pubitemid 39658191)
10. Esposito V, Manente L, Perna A, Gargiulo M, Viglietti R, Sangiovanni V, Doula N, Liuzzi G, Baldi A, De Luca A and Chirianni A: Role of NEDD8 in HIV-associated lipodystrophy. Differentiation 77: 148-153, 2009.
11. Otto TC and Lane MD: Adipose development: from stem cell to adipocyte. Crit Rev Biochem Mol Bio 40: 229-242, 2005. (Pubitemid 41140883)
12. Dowell P, Flexner C, Kwiterovichi PO and Lane MD: Suppression of pre adipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors. J Biol C 275: 41325-41332, 2000. (Pubitemid 32054966)
13. Adachi T, Toishi T, Wu H, Kamiya T and Hara H: Expression of extracellular superoxide dismutase during adipose differentiation in 3T3-L1 cells. Redox Report 14: 34-40, 2009.
14. Eriksson JW: Metabolic stress in insulin's target cells leads to ROS accumulation: A hypothetical common pathway causing insulin resistance. FEBS Lett 581: 3734-3742, 2007.
15. Abraham NG and Kappas A: Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 60: 79-127, 2008. (Pubitemid 351439218)
16. Vanella L, Kim DH, Asprinio D, Peterson SJ, Barbagallo I, Vanella A, Goldstein D, Ikehara S, Kappas A and Abraham NG: HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage. Bone 46: 236-43, 2010.
17. Wagener FA, Volk HD, Willis D, Abraham NG, Soares MP, Adema GJ and Figdor CG: Different faces of the heme-heme oxygenase system in inflammation. Pharmacol Rev 55: 551-571, 2003. (Pubitemid 37013215)