Troponin T percentiles from a random population sample, emergency room patients and patients with myocardial infarction

Clinical Chemistry

Volumn 58, Issue 3, 2012, Pages 628-637

  Hammarsten, Ola ^a   Fu, Michael L X ^a   Sigurjonsdottir, Runa ^a   Petzold, Max ^a   Said, Lina ^a   Landin Wilhelmsen, Kerstin ^a   Widgren, Bengt ^b   Larsson, Mårten ^a   Johanson, Per ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b University of Gothenburg ^*  (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

TROPONIN T;

ADULT; AGED; ARTICLE; EMERGENCY WARD; FEMALE; HEART INFARCTION; HOSPITALIZATION; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION;

ADULT; AGED; AGED, 80 AND OVER; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; IMMUNOASSAY; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PATIENTS; SENSITIVITY AND SPECIFICITY; TROPONIN T;

EID: 84857868710     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2011.171496     Document Type: Article

References (27)

1. Apple FS. A new season for cardiac troponin assays: it's time to keep a scorecard. Clin Chem 2009;55:1303-6.
2. Giannitsis E, Kurz K, Hallermayer K, Jarausch J, Jaffe AS, Katus HA. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem 2010;56:254-61.
3. Giannitsis E, Becker M, Kurz K, Hess G, Zdunek D, Katus HA. High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission. Clin Chem 2010;56:642-50.
4. Aldous SJ, Florkowski CM, Crozier IG, Elliott J, George P, Lainchbury JG, et al. Comparison of high sensitivity and contemporary troponin assays for the early detection of acute myocardial infarction in the emergency department. Ann Clin Biochem 2011;48:241-8.
5. Reichlin T, Hochholzer W, Bassetti S, Steuer S, Stelzig C, Hartwiger S, et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 2009;361:858-67.
6. Reiter M, Twerenbold R, Reichlin T, Haaf P, Peter F, Meissner J, et al. Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays. Eur Heart J 2011;32:1379-89.
7. Aldous SJ, Florkowski CM, Crozier IG, George P, Mackay R, Than M. High sensitivity troponin outperforms contemporary assays in predicting major adverse cardiac events up to two years in patients with chest pain. Ann Clin Biochem 2011;48:249 -55.
8. Eggers KM, Jaffe AS, Lind L, Venge P, Lindahl B. Value of cardiac troponin I cutoff concentrations below the 99th percentile for clinical decisionmaking. Clin Chem 2009;55:85-92.
9. Mills NL, Churchhouse AM, Lee KK, Anand A, Gamble D, Shah AS, et al. Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome. JAMA 2011;305:1210-6.
10. Apple FS, Pearce LA, Smith SW, Kaczmarek JM, Murakami MM. Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events. Clin Chem 2009;55:930-7.
11. Vasile VC, Saenger AK, Kroning JM, Jaffe AS. Biological and analytical variability of a novel high-sensitivity cardiac troponin T assay. Clin Chem 2010;56:1086-90.
12. Eggers KM, Jaffe AS, Venge P, Lindahl B. Clinical implications of the change of cardiac troponin I levels in patients with acute chest pain - an evaluation with respect to the Universal Definition of Myocardial Infarction. Clin Chim Acta 2011;412:91-7.
13. Reichlin T, Irfan A, Twerenbold R, Reiter M, Hochholzer W, Burkhalter H, et al. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation 2011;124:136-45.
14. Solberg HE. The IFCC recommendation on estimation of reference intervals. The RefVal program. Clin Chem Lab Med 2004;42:710-4. (Pubitemid 39137218)
15. Wilhelmsen L, Johansson S, Rosengren A, Wallin I, Dotevall A, Lappas G. Risk factors for cardiovascular disease during the period 1985-1995 in Goteborg. Sweden. The GOT-MONICA Project. J Intern Med 1997;242:199-211. (Pubitemid 27400432)
16. Widgren BR, Jourak M. Medical Emergency Triage and Treatment System (METTS): a new protocol in primary triage and secondary priority decision in emergency medicine. J Emerg Med 2011;40:623-8.
17. Saenger AK, Beyrau R, Braun S, Cooray R, Dolci A, Freidank H, et al. Multicenter analytical evaluation of a high-sensitivity troponin T assay. Clin Chim Acta 2010;412:748-54.
18. Kelley WE, Januzzi JL, Christenson RH. Increases of cardiac troponin in conditions other than acute coronary syndrome and heart failure. Clin Chem 2009;55:2098-112.
19. Jernberg T, Attebring MF, Hambraeus K, Ivert T, James S, Jeppsson A, et al. The Swedish Websystem for enhancement and development of evidence-based care in heart disease evaluated according to recommended therapies (SWEDEHEART). Heart 2010;96:1617-21.
20. Stenestrand U, Wallentin L. Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001;285:430-6. (Pubitemid 32097261)
21. Flynn MR, Barrett C, Cosio FG, Gitt AK, Wallentin L, Kearney P, et al. The Cardiology Audit and Registration Data Standards (CARDS). European data standards for clinical cardiology practice. Eur Heart J 2005;26:308-13. (Pubitemid 40227433)
22. Thygesen K, Alpert JS, White HD, Jaffe AS, Apple FS, Galvani M, et al. Universal definition of myocardial infarction. Circulation 2007;116:2634-53. (Pubitemid 350182388)
23. Panteghini M, Pagani F, Yeo KT, Apple FS, Christenson RH, Dati F, et al. Evaluation of imprecision for cardiac troponin assays at low-range concentrations. Clin Chem 2004;50:327-32. (Pubitemid 38156373)
24. Solberg HE. RefVal: a program implementing the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values. Comput Methods Programs Biomed 1995;48:247-56. (Pubitemid 26020880)
25. Eggers KM, Lind L, Ahlstrom H, Bjerner T, Ebeling Barbier C, Larsson A, et al. Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a population-based sample of elderly subjects. Eur Heart J 2008;29:2252-8.
26. Katus HA, Remppis A, Scheffold T, Diederich KW, Kuebler W. Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction. Am J Cardiol 1991;67:1360-7.
27. Laboratory of Clinical Chemistry, Sahlgrenska University Hospital. http://webbhotell-ext.vgregion. se/sahlgrenska-klinkem-analyser/TNT.pdf (Accessed January 2012).