The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: A randomized controlled trial

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Guinovart, Caterina ^a,b,c   Dobaño, Carlota ^a,b,c   Bassat, Quique ^a,b,c   Nhabomba, Augusto ^b   Quintó, Llorenç ^a,b,c   Manaca, Maria Nélia ^b   Aguilar, Ruth ^a,b,c   Rodríguez, Mauricio H ^a,b   Barbosa, Arnoldo ^a,b   Aponte, John J ^a,b,c   Mayor, Alfredo G ^a,b,c   Renom, Montse ^a,b   Moraleda, Cinta ^a,b   Roberts, David J ^d,e   Schwarzer, Evelin ^f   Le Souëf, Peter N ^g   Schofield, Louis ^h   Chitnis, Chetan E ⁱ   Doolan, Denise L ^j   Alonso, Pedro L ^a,b,c  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Ministério de Saúde   (Mozambique)

^c CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF TURIN   (Italy)

^g UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^h WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

ⁱ INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^j QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE PLUS PYRIMETHAMINE PLUS SULFADOXINE; ANTIMALARIAL AGENT; ARTESUNATE; ERYTHROCYTE ANTIGEN; PLACEBO; PYRIMETHAMINE PLUS SULFADOXINE; PYRIMETHAMINE PLUS SULFADOXINE PLUS ARTESUNATE; QUININE; UNCLASSIFIED DRUG;

ACTIVE CASE DETECTION; ADAPTIVE IMMUNITY; AGE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURES; DOSAGE SCHEDULE COMPARISON; EARLY EXPOSURE GROUP; ETHNIC GROUP; EXPOSURE; FEMALE; HAZARD RATIO; HUMAN; INCIDENCE; INFANT; KERNICTERUS; LATE EXPOSURE GROUP; MALARIA; MALARIA CONTROL; MALE; MOZAMBICAN; NATURALLY ADAPTIVE IMMUNITY; NONHUMAN; PASSIVE CASE DETECTION; PLASMODIUM FALCIPARUM; SKIN MANIFESTATION; TREATMENT DURATION; CHEMOPROPHYLAXIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; IMMUNOLOGY; KAPLAN MEIER METHOD; MALARIA FALCIPARUM; PRESCHOOL CHILD; PREVALENCE; RANDOMIZED CONTROLLED TRIAL;

ARTESUNATE; PLASMODIUM FALCIPARUM;

ADAPTIVE IMMUNITY; AGE FACTORS; ANTIMALARIALS; CHEMOPREVENTION; CHILD, PRESCHOOL; FEMALE; HUMANS; INCIDENCE; INFANT; KAPLAN-MEIER ESTIMATE; MALARIA, FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; PREVALENCE;

EID: 84857864671     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032362     Document Type: Article

References (31)

1. Doolan DL, Dobano C, Baird JK, (2009) Acquired immunity to malaria. Clin Microbiol Rev 22: 13-36 Table of Contents.
2. Carneiro I, Roca-Feltrer A, Griffin JT, Smith L, Tanner M, et al. (2010) Age-patterns of malaria vary with severity, transmission intensity and seasonality in sub-Saharan Africa: a systematic review and pooled analysis. PLoS One 5: e8988.
3. Aponte JJ, Menendez C, Schellenberg D, Kahigwa E, Mshinda H, et al. (2007) Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation. PLoS Med 4: e242.
4. Baird J, (1995) Host age as a determinant of naturally acquired immunity to P. falciparum. Parasitology Today 11: 105-111.
5. Baird J, (1998) Age-dependent characteristics of protection vs. susceptibility to P. falciparum. Ann Trop Med Parasitol 92: 367-390.
6. Baird JK, Purnomo, Basri H, Bangs MJ, Andersen EM, Jones TR, et al. (1993) Age specific prevalence of P. falciparum among six populations with limited histories of exposure to endemic malaria. Am J Trop Med Hyg 49: 707-719.
7. Menendez C, Kahigwa E, Hirt R, Vounatsou P, Aponte JJ, et al. (1997) Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anemia and malaria in Tanzanian infants. The Lancet 350: 844-850.
8. Schellenberg D, Menéndez C, Kahigwa E, Aponte J, Vidal J, et al. (2001) Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzanian infants: a randomised placebo-controlled trial. Lancet 357: 1471-1477.
9. Schellenberg D, Menendez C, Aponte JJ, Kahigwa E, Tanner M, et al. (2005) Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial. Lancet 365: 1481-1483.
10. Guinovart C, Bassat Q, Sigauque B, Aide P, Sacarlal J, et al. (2008) Malaria in rural Mozambique. Part I: children attending the outpatient clinic. Malar J 7: 36.
11. Saute F, Aponte J, Almeda J, Ascaso C, Vaz N, et al. (2003) Malaria in southern Mozambique: incidence of clinical malaria in children living in a rural community in Manhica district. Trans R Soc Trop Med Hyg 97: 655-660.
12. Macdonald G, (1950) The analysis of malaria parasite rates in infants. Trop Dis Bull 47: 915-938.
13. Hellgren U, Kihamia CM, Bergqvist Y, Lebbad M, Premji Z, et al. (1990) Standard and reduced doses of sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum in Tanzania, with determination of drug concentrations and susceptibility in vitro. Trans R Soc Trop Med Hyg 84: 469-472.
14. Alonso PL, Smith T, Schellenberg JRMA, Masanja H, Mwankusye S, et al. (1994) Randomised trial of efficacy of SPf66 vaccine against Plasmodium falciparum malaria in children in southern Tanzania. The Lancet 344: 1175-1181.
15. Acosta CJ, Galindo CM, Schellenberg D, Aponte JJ, Kahigwa E, et al. (1999) Evaluation of the SPf66 vaccine for malaria control when delivered through the EPI scheme in Tanzania. Trop Med Int Health 4: 368-376.
16. Galindo CM, Acosta CJ, Schellenberg D, Aponte JJ, Roca A, et al. (2000) Humoral immune responses during a malaria vaccine trial in Tanzanian infants. Parasite Immunol 22: 437-443.
17. Siegrist C, (2001) Neonatal and early life vaccinology. Vaccine 19: 3331-3346.
18. Alonso PL, Saúte F, Aponte JJ, Gómez-Olivé FX, Nhacolo A, et al. INDEPTH, editor (2002) Manhiça DSS, Mozambique. Population and Health in Developing Countries Ottawa, Canada International Development Research Centre (IDRC) pp. 189-195.
19. Alonso PL, Sacarlal J, Aponte JJ, Leach A, Macete E, et al. (2004) Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial. Lancet 364: 1411-1420.
20. Ordi J, Ismail MR, Ventura PJ, Kahigwa E, Hirt R, et al. (1998) Massive chronic intervillositis of the placenta associated with malaria infection. Am J Surg Pathol 22: 1006-1011.
21. Mayor A, Serra-Casas E, Bardaji A, Sanz S, Puyol L, et al. (2009) Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women. Malar J 8: 9.
22. Smith PG, Morrow H, (1992) Methods for field trials of interventions against tropical diseases: a "toolbox" Oxford Oxford Medical Publications.
23. Royston P, (2004) Multiple imputation of missing values. Stata Journal pp. 227-241.
24. Rubin DB, (1976) Inference and missing data. Biometrika 63: 581-592.
25. Cole TJ, (1990) The LMS method for constructing normalized growth standards. Eur J Clin Nutr 44: 45-60.
26. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, Flegal KM, Guo SS, et al. (2000) CDC growth charts: United States. Adv Data pp. 1-27.
27. Abacassamo F, Enosse S, Aponte JJ, Gomez-Olive FX, Quinto L, et al. (2004) Efficacy of chloroquine, amodiaquine, sulphadoxine-pyrimethamine and combination therapy with artesunate in Mozambican children with non-complicated malaria. Trop Med Int Health 9: 200-208.
28. Aponte JJ, Aide P, Renom M, Mandomando I, Bassat Q, et al. (2007) Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial. Lancet 370: 1543-1551.
29. Abdulla S, Oberholzer R, Juma O, Kubhoja S, Machera F, et al. (2008) Safety and immunogenicity of RTS,S/AS02D malaria vaccine in infants. N Engl J Med 359: 2533-2544.
30. Bejon P, Lusingu J, Olotu A, Leach A, Lievens M, et al. (2008) Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age. N Engl J Med 359: 2521-2532.
31. Alonso PL, Sacarlal J, Aponte JJ, Leach A, Macete E, et al. (2005) Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial. Lancet 366: 2012-2018.