Holotranscobalamin: Not ready for prime time

Clinical Chemistry

Volumn 58, Issue 3, 2012, Pages 643-645

  Carmel, Ralph ^a,b  

^a NEW YORK METHODIST HOSPITAL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; METHYLMALONIC ACID;

CYANOCOBALAMIN DEFICIENCY; FOLIC ACID DEFICIENCY; HUMAN; LETTER; MALABSORPTION; PERNICIOUS ANEMIA; POLYCYTHEMIA; PREGNANCY;

FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; METHYLMALONIC ACID; TRANSCOBALAMINS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84857850551     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2011.174516     Document Type: Letter

References (5)

1. Valente E, Scott JM, Ueland PM, Cunningham C, Casey M, Molloy AM. Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B12 status in the elderly. Clin Chem 2011;57:856-63.
2. Carmel R. Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr 2011;94:348S-58S.
3. Chanarin I. The megaloblastic anaemias. 2nd ed. Oxford: Blackwell Scientific; 1979. p 141-3.
4. Carmel R. On measuring and interpreting holotranscobalamin (holotranscobalamin II) [Editorial]. Clin Chem 2002;48:407-9.
5. Hvas AM, Ellegaard J, Nexo E. Increased plasma methylmalonic acid level does not predict clinical manifestations of vitamin B12 deficiency. Arch Intern Med 2001;161:1534-41. (Pubitemid 32679567)