The first line of intra-abdominal metastatic attack: Breaching the mesothelial cell layer

Cancer Discovery

Volumn 1, Issue 2, 2011, Pages 100-102

  Kenny, Hilary A ^a   Nieman, Kristin M ^a   Mitra, Anirban K ^a   Lengyel, Ernst ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN IIA; MYOSIN IIB; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; VERY LATE ACTIVATION ANTIGEN 5;

APOPTOSIS; ARTICLE; CANCER SURVIVAL; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CLEARANCE; COLON CANCER; EPITHELIUM; FEMALE; HUMAN; MESOTHELIUM CELL; METASTASIS; MICROSCOPY; MULTICELLULAR SPHEROID; NONHUMAN; OVARY CANCER; OVARY TUMOR; PATHOLOGY; PERITONEAL CAVITY; PROGRESSION FREE SURVIVAL; TUMOR SPHEROID;

EPITHELIUM; FEMALE; HUMANS; OVARIAN NEOPLASMS; SPHEROIDS, CELLULAR;

EID: 84857839586     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-11-0117     Document Type: Article

References (12)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010;60:277-300.
2. Lengyel E. Ovarian cancer development and metastasis. Am J Pathol 2010;177:1053-64.
3. Zhang X, Pettengell R, Nasiri N, Kalia V, Dalgleish A, Barton D. Characteristics and growth patterns of human peritoneal mesothelial cells: comparison between advanced epithelial ovarian cancer and non-ovarian cancer sources. J Soc Gynecol Investig 1999;6:333-40.
4. Niedbala MJ, Crickard K, Bernacki R. Interactions of human ovarian tumor cells with human mesothelial cells grown on extracellular matrix. An in vitro model system for studying tumor cell adhesion and invasion. Exp Cell Res 1985;160:499-513.
5. Kenny HA, Krausz T, Yamada SD, Lengyel E. Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells. Int J Cancer 2007;121:1463-72.
6. Kiazek K, Mikula-Pietrasik J, Korybalska K, Dworacki G, Jörres A, Witowski J. Senescent peritoneal mesothelial cells promote ovarian cancer cell adhesions. Am J Pathol 2009;174:1230-40.
7. Iwanicki M, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, et al. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discovery 2011;1:144-57.
8. Bershadsky AD, Balaban NQ, Geiger B. Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol 2003;19:677-95.
9. Heath R, Jayne D, O'Leary R, Morrison E, Guillou P. Tumor-induced apoptosis in human mesothelial cells: a mechanism of peritoneal invasion by Fas Ligand/Fas interaction. Br J Cancer 2004;90:1437-42.
10. Mierke CJ, Frey B, Fellner M, Herrmann M, Faden L. Integrin a5b1 facilitates cancer cell invasion through enhanced contractile forces. J Cell Sci 2011;124:369-83.
11. Mitra AK, Sawada K, Tiwari P, Mui K, Gwin K, Lengyel E. Ligand independent activation of c-Met by fibronectin a5b1-integrin regulates ovarian cancer invasion and metastasis. Oncogene 2011;30:1566-76.
12. Yokoyama Y, Sedgewick G, Ramakrishnan S. Endostatin binding to ovarian cancer cells inhibits peritoneal attachment and dissemination. Cancer Res 2007;67:10813-22.