Gain of chromosome arm 1q in atypical meningioma correlates with shorter progression-free survival

Neuropathology and Applied Neurobiology

Volumn 38, Issue 2, 2012, Pages 213-219

  Jansen, M ^a,d   Mohapatra, G ^a,b   Betensky, R A ^c   Keohane, C ^e   Louis, D N ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d BEAUMONT HOSPITAL   (Ireland)

^e University College Cork and INFANT Centre   (Ireland)

Author keywords

Atypical; Classification; Genetics; Meningioma; Pathology

Indexed keywords

ADULT; AGE; ARTICLE; ATYPICAL MENINGIOMA; BACTERIAL ARTIFICIAL CHROMOSOME; CHROMOSOME 1Q; CORRELATIONAL STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE LOCUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MENINGIOMA; NEUROSURGERY; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; TUMOR RECURRENCE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 1; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MENINGEAL NEOPLASMS; MENINGIOMA; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; YOUNG ADULT;

EID: 84857837904     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2011.01222.x     Document Type: Article

References (29)

1. Riemenschneider MJ, Perry A, Reifenberger G. Histological classification and molecular genetics of meningiomas. Lancet Neurol 2006; 5: 1045-54
2. Central Brain Tumor Registry of the United States (CBTRUS). CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2004-2007. Central Brain Tumor Registry of the United States; 2011. Available at: (last accessed 28 March 2011)
3. Perry A, Scheithauer BW, Stafford SL, Lohse CM, Wollan PC. 'Malignancy' in meningiomas: a clinicopathologic study of 116 patients, with grading implications. Cancer 1999; 85: 2046-56
4. Louis DN, Budka H. Meningiomas. In World Health Organization Classification of Tumours; Pathology and Genetics of Tumours of the Central Nervous System Ed P Kleihues Lyon: IARC Press, 2000; 176-84
5. Perry A, Scheithauer BW, Budka H, von Deimling A. Meningeal tumours. In WHO Classification of Tumours of the Central Nervous System Eds DN Louis, OD Wiestler, WK Cavanee Lyon: IARC, 2007; 164-72
6. Kallio M, Sankila R, Hakulinen T, Jaaskelainen J. Factors affecting operative and excess long-term mortality in 935 patients with intracranial meningioma. Neurosurgery 1992; 31: 2-12
7. Perry A. Meningiomas. In Russell and Rubinstein's Pathology of Tumours of the Nervous System Eds R McLendon, DD Bigner London: Hodder Arnold, 2006; 427-74
8. Marosi C, Hassler M, Roessler K, Reni M, Sant M, Mazza E, Vecht C. Meningioma. Crit Rev Oncol Hematol 2008; 67: 153-71
9. Rogers L, Vogelbaum MA. Intracranial meningiomas of atypical (WHO Grade II) histology. J Neurooncol 2010; 99: 393-405
10. Aghi MK, Carter BS, Cosgrove GR, Ojemann RG, Amin-Hanjani S, Martuza RL, Curry WT Jr, Barker FG II. Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiation. Neurosurgery 2009; 64: 56-60; discussion
11. Weber RG, Bostrom J, Wolter M, Baudis M, Collins VP, Reifenberger G, Lichter P. Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression. Proc Natl Acad Sci U S A 1997; 94: 14719-24
12. Lee JY, Finkelstein S, Hamilton RL, Rekha R, King JT Jr, Omalu B. Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery 2004; 55: 1163-73
13. Lee Y, Liu J, Patel S, Cloughesy T, Lai A, Farooqi H, Seligson D, Dong J, Liau L, Becker D, Mischel P, Shams S, Nelson S. Genomic landscape of meningiomas. Brain Pathol 2010; 20: 751-62
14. Maillo A, Orfao A, Sayagues JM, Diaz P, Gomez-Moreta JA, Caballero M, Santamarta D, Santos-Briz A, Morales F, Tabernero MD. New classification scheme for the prognostic stratification of meningioma on the basis of chromosome 14 abnormalities, patient age, and tumor histopathology. J Clin Oncol 2003; 21: 3285-95
15. Ruiz J, Martinez A, Hernandez S, Zimman H, Ferrer M, Fernandez C, Saez M, Lopez-Asenjo JA, Sanz-Ortega J. Clinicopathological variables, immunophenotype, chromosome 1p36 loss and tumour recurrence of 247 meningiomas grade I and II. Histol Histopathol 2010; 25: 341-9
16. Gabeau-Lacet D, Engler D, Gupta S, Scangas GA, Betensky RA, Barker FG 2nd, Loeffler JS, Louis DN, Mohapatra G. Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome. J Neuropathol Exp Neurol 2009; 68: 1155-65
17. Uno H, Cai T, Tian L, Wei LJ. Graphical procedures for evaluating overall and subject-specific incremental values from new predictors with censored event time data. Biometrics 2011 Apr 19. doi: 10.1111/j.1541-0420.2011.01600.x. [Epub ahead of print]
18. Ozaki S, Nishizaki T, Ito H, Sasaki K. Comparative genomic hybridization analysis of genetic alterations associated with malignant progression of meningioma. J Neurooncol 1999; 41: 167-74
19. Hing S, Lu YJ, Summersgill B, King-Underwood L, Nicholson J, Grundy P, Grundy R, Gessler M, Shipley J, Pritchard-Jones K. Gain of 1q is associated with adverse outcome in favorable histology Wilms' tumors. Am J Pathol 2001; 158: 393-8
20. Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B, Lichter P. Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma. Clin Cancer Res 2006; 12 (7 Pt 1):2070-9
21. Pezzolo A, Rossi E, Gimelli S, Parodi F, Negri F, Conte M, Pistorio A, Sementa A, Pistoia V, Zuffardi O, Gambini C. Presence of 1q gain and absence of 7p gain are new predictors of local or metastatic relapse in localized resectable neuroblastoma. Neuro Oncol 2009; 11: 192-200
22. Hattinger CM, Potschger U, Tarkkanen M, Squire J, Zielenska M, Kiuru-Kuhlefelt S, Kager L, Thorner P, Knuutila S, Niggli FK, Ambros P, Gadner H, Betts DR. Prognostic impact of chromosomal aberrations in Ewing tumours. Br J Cancer 2002; 86: 1763-9
23. Fonseca R, Van Wier SA, Chng WJ, Ketterling R, Lacy MQ, Dispenzieri A, Bergsagel PL, Rajkumar SV, Greipp PR, Litzow MR, Price-Troska T, Henderson KJ, Ahmann GJ, Gertz MA. Prognostic value of chromosome 1q21 gain by fluorescent in situ hybridization and increase CKS1B expression in myeloma. Leukemia 2006; 20: 2034-40
24. Lo KC, Ma C, Bundy BN, Pomeroy SL, Eberhart CG, Cowell JK. Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma. Clin Cancer Res 2007; 13: 7022-8
25. Miwa T, Hirose Y, Sasaki H, Ezaki T, Yoshida K, Kawase T. Single-copy gain of chromosome 1q is a negative prognostic marker in pediatric nonependymal, nonpilocytic gliomas. Neurosurgery 2011; 68: 206-12
26. Asthagiri AR, Helm GA, Sheehan JP. Current concepts in management of meningiomas and schwannomas. Neurol Clin 2007; 25: 1209-30, xi
27. Milosevic MF, Frost PJ, Laperriere NJ, Wong CS, Simpson WJ. Radiotherapy for atypical or malignant intracranial meningioma. Int J Radiat Oncol Biol Phys 1996; 34: 817-22
28. Pasquier D, Bijmolt S, Veninga T, Rezvoy N, Villa S, Krengli M, Weber DC, Baumert BG, Canyilmaz E, Yalman D, Szutowicz E, Tzuk-Shina T, Mirimanoff RO. Atypical and malignant meningioma: outcome and prognostic factors in 119 irradiated patients. A multicenter, retrospective study of the Rare Cancer Network. Int J Radiat Oncol Biol Phys 2008; 71: 1388-93
29. Jo K, Park HJ, Nam DH, Lee JI, Kong DS, Park K, Kim JH. Treatment of atypical meningioma. J Clin Neurosci 2010; 17: 1362-6