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Volumn 23, Issue 5, 2012, Pages 811-819

Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ETOMOXIR; FATTY ACID; GLUTATHIONE; PENTOSE PHOSPHATE; PROTEIN;

EID: 84857837547     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E11-12-1011     Document Type: Article
Times cited : (27)

References (43)
  • 2
    • 77955483125 scopus 로고    scopus 로고
    • Activation of a metabolic gene regulatory network downstream of mTOR complex 1
    • Duvel K et al. (2010). Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 39, 171-183.
    • (2010) Mol Cell , vol.39 , pp. 171-183
    • Duvel, K.1
  • 3
    • 0028904867 scopus 로고
    • On the mechanism of interaction of steroids with human glucose 6-phosphate dehydrogenase
    • Gordon G, Mackow MC, Levy HR (1995). On the mechanism of interaction of steroids with human glucose 6-phosphate dehydrogenase. Arch Biochem Biophys 318, 25-29.
    • (1995) Arch Biochem Biophys , vol.318 , pp. 25-29
    • Gordon, G.1    Mackow, M.C.2    Levy, H.R.3
  • 4
    • 73349138892 scopus 로고    scopus 로고
    • Regulation of tissue growth through nutrient sensing
    • Hietakangas V, Cohen SM (2009). Regulation of tissue growth through nutrient sensing. Annu Rev Genet 43, 389-410.
    • (2009) Annu Rev Genet , vol.43 , pp. 389-410
    • Hietakangas, V.1    Cohen, S.M.2
  • 5
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil GS (2010). Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140, 900-917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 6
    • 84863012730 scopus 로고    scopus 로고
    • Sustained activation of PPAR{alpha} by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice
    • Oct 18, doi: 10.1096/fj.11-194019 [Epub ahead of print]
    • Huang J, Jia Y, Fu T, Viswakarma N, Bai L, Rao MS, Zhu Y, Borensztajn J, Reddy JK (2011a). Sustained activation of PPAR{alpha} by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice. FASEB J Oct 18, doi: 10.1096/fj.11-194019 [Epub ahead of print].
    • (2011) FASEB J
    • Huang, J.1    Jia, Y.2    Fu, T.3    Viswakarma, N.4    Bai, L.5    Rao, M.S.6    Zhu, Y.7    Borensztajn, J.8    Reddy, J.K.9
  • 7
    • 80052459616 scopus 로고    scopus 로고
    • Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice
    • Huang J et al. (2011b). Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice. Am J Pathol 179, 703-713.
    • (2011) Am J Pathol , vol.179 , pp. 703-713
    • Huang, J.1
  • 8
    • 77953501690 scopus 로고    scopus 로고
    • BiP availability distinguishes states of homeostasis and stress in the endoplasmic reticulum of living cells
    • Lai CW, Aronson DE, Snapp EL (2010). BiP availability distinguishes states of homeostasis and stress in the endoplasmic reticulum of living cells. Mol Biol Cell 21, 1909-1921.
    • (2010) Mol Biol Cell , vol.21 , pp. 1909-1921
    • Lai, C.W.1    Aronson, D.E.2    Snapp, E.L.3
  • 9
    • 43749114512 scopus 로고    scopus 로고
    • Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy
    • Lavery GG et al. (2008). Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy. J Biol Chem 283, 8453-8461.
    • (2008) J Biol Chem , vol.283 , pp. 8453-8461
    • Lavery, G.G.1
  • 10
    • 45849137877 scopus 로고    scopus 로고
    • Regulation of hepatic lipogenesis by the transcription factor XBP1
    • DOI 10.1126/science.1158042
    • Lee AH, Scapa EF, Cohen DE, Glimcher LH (2008). Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320, 1492-1496. (Pubitemid 351929428)
    • (2008) Science , vol.320 , Issue.5882 , pp. 1492-1496
    • Lee, A.-H.1    Scapa, E.F.2    Cohen, D.E.3    Glimcher, L.H.4
  • 11
    • 70349905357 scopus 로고    scopus 로고
    • Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis
    • Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR, Tabas I (2009). Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol 186, 783-792.
    • (2009) J Cell Biol , vol.186 , pp. 783-792
    • Li, G.1    Mongillo, M.2    Chin, K.T.3    Harding, H.4    Ron, D.5    Marks, A.R.6    Tabas, I.7
  • 12
    • 0037106329 scopus 로고    scopus 로고
    • Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucoseregulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: Activating transcription factor 6 as a target for stress-induced phosphorylation
    • Luo S, Lee AS (2002). Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucoseregulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation. Biochem J 366, 787-795.
    • (2002) Biochem J , vol.366 , pp. 787-795
    • Luo, S.1    Lee, A.S.2
  • 15
    • 56349087407 scopus 로고    scopus 로고
    • Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions
    • Merksamer PI, Trusina A, Papa FR (2008). Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell 135, 933-947.
    • (2008) Cell , vol.135 , pp. 933-947
    • Merksamer, P.I.1    Trusina, A.2    Papa, F.R.3
  • 17
    • 33846223428 scopus 로고    scopus 로고
    • Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress
    • DOI 10.1128/MCB.00408-06
    • Nadanaka S, Okada T, Yoshida H, Mori K (2007). Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress. Mol Cell Biol 27, 1027-1043. (Pubitemid 46174565)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.3 , pp. 1027-1043
    • Nadanaka, S.1    Okada, T.2    Yoshida, H.3    Mori, K.4
  • 19
    • 44349163999 scopus 로고    scopus 로고
    • Dephosphorylation of Translation Initiation Factor 2alpha Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice
    • DOI 10.1016/j.cmet.2008.04.011, PII S1550413108001435
    • Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D (2008). Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab 7, 520-532. (Pubitemid 351729207)
    • (2008) Cell Metabolism , vol.7 , Issue.6 , pp. 520-532
    • Oyadomari, S.1    Harding, H.P.2    Zhang, Y.3    Oyadomari, M.4    Ron, D.5
  • 20
    • 40649104735 scopus 로고    scopus 로고
    • Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis
    • DOI 10.1016/j.molcel.2007.12.023, PII S109727650800066X
    • Özcan U, Özcan L, Yilmaz E, Duvel K, Sahin M, Manning BD, Hotamisligil GS (2008). Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell 29, 541-551. (Pubitemid 351384644)
    • (2008) Molecular Cell , vol.29 , Issue.5 , pp. 541-551
    • Ozcan, U.1    Ozcan, L.2    Yilmaz, E.3    Duvel, K.4    Sahin, M.5    Manning, B.D.6    Hotamisligil, G.S.7
  • 22
    • 79955601028 scopus 로고    scopus 로고
    • Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
    • Pike LS, Smift AL, Croteau NJ, Ferrick DA, Wu M (2010). Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim Biophys Acta 1807, 726-734.
    • (2010) Biochim Biophys Acta , vol.1807 , pp. 726-734
    • Pike, L.S.1    Smift, A.L.2    Croteau, N.J.3    Ferrick, D.A.4    Wu, M.5
  • 23
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • DOI 10.1038/nrm2199, PII NRM2199
    • Ron D, Walter P (2007). Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8, 519-529. (Pubitemid 46985379)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 25
    • 77953153048 scopus 로고    scopus 로고
    • Regulation of basal cellular physiology by the homeostatic unfolded protein response
    • Rutkowski DT, Hegde RS (2010). Regulation of basal cellular physiology by the homeostatic unfolded protein response. J Cell Biol 189, 783-794.
    • (2010) J Cell Biol , vol.189 , pp. 783-794
    • Rutkowski, D.T.1    Hegde, R.S.2
  • 26
    • 57049111040 scopus 로고    scopus 로고
    • UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
    • Rutkowski DT et al. (2008). UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell 15, 829-840.
    • (2008) Dev Cell , vol.15 , pp. 829-840
    • Rutkowski, D.T.1
  • 27
    • 59149095128 scopus 로고    scopus 로고
    • Characterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione
    • Seefeldt T, Zhao Y, Chen W, Raza AS, Carlson L, Herman J, Stoebner A, Hanson S, Foll R, Guan X (2009). Characterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione. J Biol Chem 284, 2729-2737.
    • (2009) J Biol Chem , vol.284 , pp. 2729-2737
    • Seefeldt, T.1    Zhao, Y.2    Chen, W.3    Raza, A.S.4    Carlson, L.5    Herman, J.6    Stoebner, A.7    Hanson, S.8    Foll, R.9    Guan, X.10
  • 28
    • 0035085155 scopus 로고    scopus 로고
    • Very-low-density lipoprotein assembly and secretion
    • DOI 10.1097/00041433-200104000-00008
    • Shelness GS, Sellers JA (2001). Very-low-density lipoprotein assembly and secretion. Curr Opin Lipidol 12, 151-157. (Pubitemid 32242922)
    • (2001) Current Opinion in Lipidology , vol.12 , Issue.2 , pp. 151-157
    • Shelness, G.S.1    Sellers, J.A.2
  • 29
    • 0021077942 scopus 로고
    • Cellular redox changes and response to drugs and toxic agents
    • Sies H, Brigelius R, Wefers H, Muller A, Cadenas E (1983). Cellular redox changes and response to drugs and toxic agents. Fundam Appl Toxicol 3, 200-208. (Pubitemid 14241863)
    • (1983) Fundamental and Applied Toxicology , vol.3 , Issue.4 , pp. 200-208
    • Sies, H.1    Brigelius, R.2    Wefers, H.3
  • 30
    • 34248142302 scopus 로고    scopus 로고
    • 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells
    • DOI 10.1158/0008-5472.CAN-06-3717
    • Simons AL, Ahmad IM, Mattson DM, Dornfeld KJ, Spitz DR (2007). 2-Deoxyd- glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Res 67, 3364-3370. (Pubitemid 46724876)
    • (2007) Cancer Research , vol.67 , Issue.7 , pp. 3364-3370
    • Simons, A.L.1    Ahmad, I.M.2    Mattson, D.M.3    Dornfeld, K.J.4    Spitz, D.R.5
  • 31
    • 65249134998 scopus 로고    scopus 로고
    • Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae
    • Tan SX, Teo M, Lam YT, Dawes IW, Perrone GG (2009). Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Biol Cell 20, 1493-1508.
    • (2009) Mol Biol Cell , vol.20 , pp. 1493-1508
    • Tan, S.X.1    Teo, M.2    Lam, Y.T.3    Dawes, I.W.4    Perrone, G.G.5
  • 32
    • 33745984570 scopus 로고    scopus 로고
    • Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices
    • DOI 10.1016/j.tiv.2006.01.021, PII S0887233306000324
    • Vickers AE, Bentley P, Fisher RL (2006). Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices. Toxicol In Vitro 20, 1173-1182. (Pubitemid 44067372)
    • (2006) Toxicology in Vitro , vol.20 , Issue.7 , pp. 1173-1182
    • Vickers, A.E.M.1    Bentley, P.2    Fisher, R.L.3
  • 33
    • 57649178844 scopus 로고    scopus 로고
    • The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: A review
    • Wamelink MM, Struys EA, Jakobs C (2008). The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review. J Inherit Metab Dis 31, 703-717.
    • (2008) J Inherit Metab Dis , vol.31 , pp. 703-717
    • Wamelink, M.M.1    Struys, E.A.2    Jakobs, C.3
  • 34
    • 0034282912 scopus 로고    scopus 로고
    • Activation of ATF6 and an ATF6 binding site by the endoplasmic reticulum stress response
    • Wang Y, Shen J, Arenzana N, Tirasophon W, Kaufma RJ, Prywes R (2000). Activation of ATF6 and an ATF6 binding site by the endoplasmic reticulum stress response. J Biol Chem 275, 27013-27020.
    • (2000) J Biol Chem , vol.275 , pp. 27013-27020
    • Wang, Y.1    Shen, J.2    Arenzana, N.3    Tirasophon, W.4    Kaufma, R.J.5    Prywes, R.6
  • 35
    • 67749135249 scopus 로고    scopus 로고
    • The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
    • Wang Y, Vera L, Fischer WH, Montminy M (2009). The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-537.
    • (2009) Nature , vol.460 , pp. 534-537
    • Wang, Y.1    Vera, L.2    Fischer, W.H.3    Montminy, M.4
  • 36
    • 0028091713 scopus 로고
    • Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzyme
    • Weis BC, Cowan AT, Brown N, Foster DW, McGarry JD (1994). Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzyme. J Biol Chem 269, 26443-26448.
    • (1994) J Biol Chem , vol.269 , pp. 26443-26448
    • Weis, B.C.1    Cowan, A.T.2    Brown, N.3    Foster, D.W.4    McGarry, J.D.5
  • 39
    • 1442348164 scopus 로고    scopus 로고
    • Peroxisomal Proliferator-Activated Receptor alpha Deficiency Diminishes Insulin-Responsiveness of Gluconeogenic/Glycolytic/Pentose Gene Expression and Substrate Cycle Flux
    • DOI 10.1210/en.2003-1173
    • Xu J, Chang V, Joseph SB, Trujillo C, Bassilian S, Saad MF, Lee WN, Kurland IJ (2004). Peroxisomal proliferator-activated receptor alpha deficiency diminishes insulin-responsiveness of gluconeogenic/glycolytic/ pentose gene expression and substrate cycle flux. Endocrinology 145, 1087-1095. (Pubitemid 38280987)
    • (2004) Endocrinology , vol.145 , Issue.3 , pp. 1087-1095
    • Xu, J.1    Chang, V.2    Joseph, S.B.3    Trujillo, C.4    Bassilian, S.5    Saad, M.F.6    Lee, W.N.P.7    Kurland, I.J.8
  • 40
    • 77956232915 scopus 로고    scopus 로고
    • Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress
    • Yamamoto K, Takahara K, Oyadomari S, Okada T, Sato T, Harada A, Mori K (2010). Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress. Mol Biol Cell 21, 2975-2986.
    • (2010) Mol Biol Cell , vol.21 , pp. 2975-2986
    • Yamamoto, K.1    Takahara, K.2    Oyadomari, S.3    Okada, T.4    Sato, T.5    Harada, A.6    Mori, K.7
  • 41
    • 65049085305 scopus 로고    scopus 로고
    • Glutathione in liver diseases and hepatotoxicity
    • Yuan L, Kaplowitz N (2009). Glutathione in liver diseases and hepatotoxicity. Mol Aspects Med 30, 29-41.
    • (2009) Mol Aspects Med , vol.30 , pp. 29-41
    • Yuan, L.1    Kaplowitz, N.2
  • 42
    • 64649100723 scopus 로고    scopus 로고
    • Effects of glutathione reductase inhibition on cellular thiol redox state and related systems
    • Zhao Y, Seefeldt T, Chen W, Wang X, Matthees D, Hu Y, Guan X (2009). Effects of glutathione reductase inhibition on cellular thiol redox state and related systems. Arch Biochem Biophys 485, 56-62.
    • (2009) Arch Biochem Biophys , vol.485 , pp. 56-62
    • Zhao, Y.1    Seefeldt, T.2    Chen, W.3    Wang, X.4    Matthees, D.5    Hu, Y.6    Guan, X.7


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