CRTH2 antagonist MK-7246: A synthetic evolution from discovery through development

Journal of Organic Chemistry

Volumn 77, Issue 5, 2012, Pages 2299-2309

  Molinaro, Carmela ^a,b   Bulger, Paul G ^a   Lee, Ernest E ^b   Kosjek, Birgit ^a   Lau, Stephen ^b   Gauvreau, Danny ^b   Howard, Melissa E ^a   Wallace, Debra J ^a   O'Shea, Paul D ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AZIRIDINES; BIOCATALYSIS; CLINICAL EVALUATION; EFFICIENCY GAIN; ENABLING TOOLS; IN-VITRO EVALUATION; MEDICINAL CHEMISTRY; N-H INSERTION; PROCESS CHEMISTRY; RELEVANT TARGET; SINGLE-STEP; STRUCTURE-ACTIVITY RELATIONSHIPS; SYNTHETIC ROUTES; TARGET MOLECULE;

IONIC LIQUIDS; IRIDIUM; KETONES; MANUFACTURE; ORGANIC COMPOUNDS;

SYNTHETIC APERTURE RADAR;

AMINE; AMINOTRANSFERASE; AZIRIDINE; KETONE; MK 7246; RECEPTOR BLOCKING AGENT; SULFOXONIUM YLIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOCATALYSIS; BIOTRANSFORMATION; CROSS LINKING; DEHYDRATION; DRUG SYNTHESIS; ENANTIOSELECTIVITY; IN VITRO STUDY; RING OPENING; STRUCTURE ACTIVITY RELATION;

CARBOLINES; DRUG DISCOVERY; MOLECULAR STRUCTURE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857809957     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo202620r     Document Type: Article

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