Inhaled glucocorticoids during pregnancy and offspring pediatric diseases: A national cohort study

American Journal of Respiratory and Critical Care Medicine

Volumn 185, Issue 5, 2012, Pages 557-563

  Tegethoff, Marion ^a   Greene, Naomi ^b   Olsen, Jrøn ^b,c   Schaffner, Emmanuel ^a,d   Meinlschmidt, Gunther ^a,e,f  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF AARHUS   (Denmark)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^e National Centre of Competence in Research Swiss Etiological Study of Adjustment and Mental Health   (Switzerland)

^f RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE; BUDESONIDE; FLUTICASONE; GLUCOCORTICOID;

ADULT; ARTICLE; ASTHMA; CHILD; CHILDHOOD DISEASE; ENDOCRINE DISEASE; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; METABOLIC DISORDER; NUTRITIONAL DISORDER; PREGNANCY; PREGNANT WOMAN; PRENATAL DRUG EXPOSURE; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; PROPENSITY SCORE; RISK FACTOR; SCHOOL CHILD; TREATMENT INDICATION;

ADMINISTRATION, INHALATION; ADULT; ANDROSTADIENES; ANTI-ASTHMATIC AGENTS; ASTHMA; BECLOMETHASONE; BUDESONIDE; CHILD; CHILD, PRESCHOOL; DENMARK; ENDOCRINE SYSTEM DISEASES; FEMALE; GLUCOCORTICOIDS; HUMANS; LOGISTIC MODELS; MALE; METABOLIC DISEASES; MORBIDITY; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 84857809133     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201108-1482OC     Document Type: Article

References (62)

1. Bakhireva LN, Schatz M, Jones KL, Chambers CD. Asthma control during pregnancy and the risk of preterm delivery or impaired fetal growth. Ann Allergy Asthma Immunol 2008;101:137-143.
2. Kwon HL, Belanger K, Bracken MB. Asthma prevalence among pregnant and childbearing-aged women in the United States: estimates from national health surveys. Ann Epidemiol 2003;13:317-324. (Pubitemid 36765394)
3. Dahl R, Bjermer L. Nordic consensus report on asthma management. Nordic Asthma Consensus Group. Respir Med 2000;94:299-327. (Pubitemid 30323566)
4. Skadhauge LR, Baelum J, Siersted HC, Sherson DL, Dahl S, Thomsen GF, Omland O, Taudorf E, Sigsgaard TI. The occurrence of asthma among young adults. A population-based study in five west Danish counties. Ugeskr Laeger 2005;167:648-651. (Pubitemid 40260549)
5. National Heart Lung and Blood Institute, National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. NAEPP expert panel report. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. J Allergy Clin Immunol 2005;115:34-46.
6. Barnes PJ. Inhaled glucocorticoids for asthma. N Engl J Med 1995;332: 868-875.
7. Christensson C, Thoren A, Lindberg B. Safety of inhaled budesonide: clinical manifestations of systemic corticosteroid-related adverse effects. Drug Saf 2008;31:965-988.
8. Dombrowski MP, Schatz M, Wise R, Thom EA, Landon M, Mabie W, Newman RB,McNellis D, Hauth JC, LindheimerM, et al. Randomized trial of inhaled beclomethasone dipropionate versus theophylline for moderate asthma during pregnancy. Am J Obstet Gynecol 2004;190:737-744. (Pubitemid 38406786)
9. Namazy JA, Schatz M. Treatment of asthma during pregnancy and perinatal outcomes. Curr Opin Allergy Clin Immunol 2005;5:229-233. (Pubitemid 40694987)
10. Norjavaara E, de Verdier MG. Normal pregnancy outcomes in a population-based study including 2,968 pregnant women exposed to budesonide. J Allergy Clin Immunol 2003;111:736-742. (Pubitemid 36470242)
11. Rahimi R, Nikfar S, Abdollahi M. Meta-analysis finds use of inhaled corticosteroids during pregnancy safe: a systematic meta-analysis review. Hum Exp Toxicol 2006;25:447-452. (Pubitemid 44384586)
12. Wendel PJ, Ramin SM, Barnett-Hamm C, Rowe TF, Cunningham FG. Asthma treatment in pregnancy: a randomized controlled study. Am J Obstet Gynecol 1996;175:150-154. (Pubitemid 26282221)
13. Olesen C, Thrane N, Nielsen GL, Sorensen HT, Olsen J. A population-based prescription study of asthma drugs during pregnancy: changing the intensity of asthma therapy and perinatal outcomes. Respiration 2001;68:256-261. (Pubitemid 32588899)
14. Lipworth BJ. Systemic adverse effects of inhaled corticosteroid therapy: a systematic review and meta-analysis. Arch InternMed 1999;159:941-955. (Pubitemid 29222495)
15. McCusker C, Hamid Q. Managing asthma during pregnancy: what information do we need to optimize care? Am J Respir Crit Care Med 2011;183:687-688.
16. Seckl JR, Meaney MJ. Glucocorticoid programming. Ann N Y Acad Sci 2004;1032:63-84. (Pubitemid 40298461)
17. Tegethoff M, Greene N, Olsen J, Schaffner E, Meinlschmidt G. Stress during pregnancy and offspring pediatric disease: a national cohort study. Environ Health Perspect 2011;119:1647-1652.
18. Olsen J, Melbye M, Olsen SF, Sorensen TI, Aaby P, Andersen AM, Taxbol D, Hansen KD, Juhl M, Schow TB, et al. The Danish National Birth Cohort: its background, structure and aim. Scand J Public Health 2001;29:300-307. (Pubitemid 33731020)
19. Norwitz ER, Edusa V, Park JS. Maternal physiology and complications of multiple pregnancy. Semin Perinatol 2005;29:338-348. (Pubitemid 41790305)
20. Santema JG, Bourdrez P, Wallenburg HC. Maternal and perinatal complications in triplet compared with twin pregnancy. Eur J Obstet Gynecol Reprod Biol 1995;60:143-147.
21. Morley R. Can we generalise from findings in twins? Paediatr Perinat Epidemiol 2005;19:54-59. (Pubitemid 40260783)
22. Baumeister H, Kriston L, Bengel J, Harter M. High agreement of self-report and physician-diagnosed somatic conditions yields limited bias in examining mental-physical comorbidity. J Clin Epidemiol 2010;63:558-565.
23. Christensen J, Vestergaard M, Olsen J, Sidenius P. Validation of epilepsy diagnoses in the Danish National Hospital Register. Epilepsy Res 2007;75:162-170. (Pubitemid 47053957)
24. Andersen TF, Madsen M, Jorgensen J, Mellemkjoer L, Olsen JH. The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 1999;46:263-268. (Pubitemid 29299976)
25. Moth G, Vedsted P, Schiotz PO. National registry diagnoses agree with medical records on hospitalized asthmatic children. Acta Paediatr 2007;96:1470-1473. (Pubitemid 47416433)
26. Vestergaard M, Obel C, Henriksen TB, Christensen J, Madsen KM, Ostergaard JR, Olsen J. The Danish National Hospital Register is a valuable study base for epidemiologic research in febrile seizures. J Clin Epidemiol 2006;59:61-66. (Pubitemid 41797476)
27. Sorensen HT, Larsen BO. A population-based Danish data resource with possible high validity in pharmacoepidemiological research. J Med Syst 1994;18:33-38. (Pubitemid 24177302)
28. Danish National Board of Health. Classification of diseases. 10th revision. Copenhagen: Danish National Board of Health; 1993.
29. Gissler M, Rahkonen O, Jarvelin MR, Hemminki E. Social class differences in health until the age of seven years among the Finnish 1987 birth cohort. Soc Sci Med 1998;46:1543-1552. (Pubitemid 28288688)
30. Bech BH, Nohr EA, Vaeth M, Henriksen TB, Olsen J. Coffee and fetal death: a cohort study with prospective data. Am J Epidemiol 2005;162:983-990. (Pubitemid 41619469)
31. Dockerty JD, Draper G, Vincent T, Rowan SD, Bunch KJ. Case-control study of parental age, parity and socioeconomic level in relation to childhood cancers. Int J Epidemiol 2001;30:1428-1437. (Pubitemid 34134302)
32. Hassold T, Chiu D. Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy. Hum Genet 1985;70:11-17. (Pubitemid 15098257)
33. Waters E, Doyle J, Wolfe R, Wright M,Wake M, Salmon L. Influence of parental gender and self-reported health and illness on parent-reported child health. Pediatrics 2000;106:1422-1428.
34. Gissler M, Jarvelin MR, Louhiala P, Hemminki E. Boys have more health problems in childhood than girls: follow-up of the 1987 Finnish birth cohort. Acta Paediatr 1999;88:310-314. (Pubitemid 29144139)
35. Washburn TC, Medearis DN Jr, Childs B. Sex differences in susceptibility to infections. Pediatrics 1965;35:57-64.
36. Braitman LE, Rosenbaum PR. Rare outcomes, common treatments: analytic strategies using propensity scores.Ann InternMed 2002;137:693-695. (Pubitemid 35176104)
37. Rosenbaum PR. Discussing hidden bias in observational studies. Ann Intern Med 1991;115:901-905.
38. Mortimer KJ, Harrison TW, Tattersfield AE. Effects of inhaled corticosteroids on bone. Ann Allergy Asthma Immunol 2005;94:15-21; quiz 22-13, 79.
39. Vandenbroucke JP, von Elm E, Altman DG, Gotzsche PC, Mulrow CD, Pocock SJ, Poole C, Schlesselman JJ, Egger M. Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. PLoS Med 2007;4:e297.
40. Hodyl NA, Stark M, Osei-Kumah A, Bowman M, Gibson P, Clifton VL. Fetal glucocorticoid regulated pathways are not affected by inhaled corticosteroid use for asthma during pregnancy. Am J Respir Crit Care Med 2011;183:716-722.
41. Kavelaars A, van der Pompe G, Bakker JM, van Hasselt PM, Cats B, Visser GH, Heijnen CJ. Altered immune function in human newborns after prenatal administration of betamethasone: enhanced natural killer cell activity and decreased T cell proliferation in cord blood. Pediatr Res 1999;45:306-312. (Pubitemid 29157759)
42. Doyle LW, Ford GW, Davis NM, Callanan C. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children. Clin Sci (Lond) 2000;98:137-142. (Pubitemid 30105520)
43. MacArthur BA, Howie RN, Dezoete JA, Elkins J. School progress and cognitive development of 6-year-old children whose mothers were treated antenatally with betamethasone. Pediatrics 1982;70:99-105. (Pubitemid 12078083)
44. Seckl JR. Prenatal glucocorticoids and long-term programming. Eur J Endocrinol 2004;151:U49-U62. (Pubitemid 39627056)
45. Murphy KE, Hannah ME, Willan AR, Hewson SA, Olsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, et al. Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomized controlled trial. Lancet 2008;372:2143-2151.
46. Noorlander CW, De Graan PN, Middeldorp J, Van Beers JJ, Visser GH. Ontogeny of hippocampal corticosteroid receptors: effects of antenatal glucocorticoids in human and mouse. J Comp Neurol 2006;499:924-932. (Pubitemid 44892819)
47. Drake AJ, Tang JI, Nyirenda MJ. Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease. Clin Sci (Lond) 2007;113:219-232. (Pubitemid 47372680)
48. Tegethoff M, Pryce C, Meinlschmidt G. Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary- adrenal axis function in humans: a systematic review. Endocr Rev 2009;30:753-789.
49. Hodyl NA, Stark MJ, Osei-Kumah A, Bowman M, Gibson P, Clifton VL. Fetal glucocorticoid-regulated pathways are not affected by inhaled corticosteroid use for asthma during pregnancy. Am J Respir Crit Care Med 2011;183:716-722.
50. Barbazanges A, Piazza PV, Le Moal M, Maccari S. Maternal glucocorticoid secretion mediates long-term effects of prenatal stress. J Neurosci 1996;16:3943-3949. (Pubitemid 26176058)
51. Nohr EA, Frydenberg M, Henriksen TB, Olsen J. Does low participation in cohort studies induce bias? Epidemiology 2006;17:413-418. (Pubitemid 44305514)
52. Wolke D, Waylen A, Samara M, Steer C, Goodman R, Ford T, Lamberts K. Selective drop-out in longitudinal studies and non-biased prediction of behaviour disorders. Br J Psychiatry 2009;195:249-256.
53. Hansen D, Lou HC, Olsen J. Serious life events and congenital malformations: a national study with complete follow-up. Lancet 2000;356:875-880.
54. Enriquez R, Griffin MR, Carroll KN, Wu P, Cooper WO, Gebretsadik T, Dupont WD, Mitchel EF, Hartert TV. Effect of maternal asthma and asthma control on pregnancy and perinatal outcomes. J Allergy Clin Immunol 2007;120:625-630. (Pubitemid 47320762)
55. Olesen C, Sondergaard C, Thrane N, Nielsen GL, de Jong-van den Berg L, Olsen J. Do pregnant women report use of dispensed medications? Epidemiology 2001;12:497-501.
56. Rockenbauer M, Olsen J, Czeizel AE, Pedersen L, Sorensen HT. Recall bias in a case-control surveillance system on the use of medicine during pregnancy. Epidemiology 2001;12:461-466. (Pubitemid 32566489)
57. Bar-Oz B, Moretti ME, Mareels G, Van Tittelboom T, Koren G. Reporting bias in retrospective ascertainment of drug-induced embryopathy. Lancet 1999;354:1700-1701. (Pubitemid 29533065)
58. Stausberg J, Lehmann N, Kaczmarek D, Stein M. Reliability of diagnoses coding with ICD-10. Int J Med Inform 2008;77:50-57. (Pubitemid 350161422)
59. Dalziel SR, Walker NK, Parag V, Mantell C, Rea HH, Rodgers A, Harding JE. Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. Lancet 2005;365:1856-1862. (Pubitemid 40744963)
60. Tegethoff M, Greene N, Olsen J, Meyer AH, Meinlschmidt G. Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study. PLoS ONE 2010;5:e14478.
61. Tegethoff M, Greene N, Olsen J, Meyer AH, Meinlschmidt G. Maternal psychosocial adversity during pregnancy is associated with length of gestation and offspring size at birth: evidence from a population-based cohort study. Psychosom Med 2010;72:419-426.
62. Tegethoff M, Raul JS, Jamey C, Khelil MB, Ludes B, Meinlschmidt G. Dehydroepiandrosterone in nails of infants: a potential biomarker of intrauterine responses to maternal stress. Biol Psychol 2011;87:414-420.