Supercritical carbon dioxide+ethanol mixtures for the antisolvent micronization of hydrosoluble materials

Chemical Engineering Journal

Volumn 187, Issue , 2012, Pages 401-409

  De Marco, Iolanda ^a   Reverchon, Ernesto ^a  

^a UNIVERSITY OF SALERNO   (Italy)

Author keywords

Bovine serum albumin; Expanded liquid antisolvent process; Hydrosoluble proteins

Indexed keywords

ANTI-SOLVENTS; ANTISOLVENT PRECIPITATION; BOVINE SERUM ALBUMINS; ETHANOL MIXTURES; EXPANDED LIQUID; MEAN DIAMETER; MICRO AND NANO-PARTICLE; MICRO-PARTICLES; MICRONIZATIONS; OPERATING CONDITION; PROCESS PARAMETERS; SUPERCRITICAL CARBON DIOXIDES; WATER-SOLUBLE MATERIALS;

BODY FLUIDS; CARBON DIOXIDE; FLOCCULATION; LIQUIDS; MAMMALS; NANOPARTICLES; PRECIPITATION (CHEMICAL); SUPERCRITICAL FLUID EXTRACTION; YTTRIUM; YTTRIUM COMPOUNDS;

ETHANOL;

BOVINAE;

EID: 84857800934     PISSN: 13858947     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cej.2012.01.135     Document Type: Article

References (25)

1. Shariati A., Peters C.J. Recent developments in particle design using supercritical fluids. Current Opinion in Solid State and Materials Science 2003, 7:371-383.
2. Bahrami M., Ranjbarian S. Production of micro- and nano-composite particles by supercritical carbon dioxide. Journal of Supercritical Fluids 2007, 40:263-283.
3. Byrappa K., Ohara S., Adschiri T. Nanoparticles synthesis using supercritical fluid technology - towards biomedical applications. Advanced Drug Delivery Reviews 2008, 60:299-327.
4. Hakuta Y., Hayashi H., Arai K. Fine particle formation using supercritical fluids. Current Opinion in Solid State & Materials Science 2003, 7(4-5):341-351.
5. Reverchon E. Supercritical antisolvent precipitation of micro- and nano-particles. Journal of Supercritical Fluids 1999, 15(1):1-21.
6. Reverchon E., De Marco I., Torino E. Nanoparticles production by supercritical antisolvent precipitation: a general interpretation. Journal of Supercritical Fluids 2007, 43(1):126-138.
7. Reverchon E., Adami R., Caputo G., De Marco I. Spherical microparticles production by supercritical antisolvent precipitation: interpretation of results. Journal of Supercritical Fluids 2008, 47(1):70-84.
8. Reverchon E., De Marco I., Adami R., Caputo G. Expanded micro-particles by supercritical antisolvent precipitation: interpretation of results. Journal of Supercritical Fluids 2008, 44(1):98-108.
9. Reverchon E., Torino E., Dowy S., Braeuer A., Leipertz A. Interactions of phase equilibria, jet fluid dynamics and mass transfer during supercritical antisolvent micronization. Chemical Engineering Journal 2010, 156:446-458.
10. Reverchon E., De Marco I. Mechanisms controlling supercritical antisolvent precipitate morphology. Chemical Engineering Journal 2011, 169:358-370.
11. Sabirzyanov A.N., Il'in A.P., Akhunov A.R., Gumerov F.M. Solubility of water in supercritical carbon dioxide. High Temperature 2002, 40:203-206.
12. 2 at elevated pressures. Journal of Chemical & Engineering Data 1996, 41:839-843.
13. Durling N.E., Catchpole O.J., Tallon S.J., Grey J.B. Measurement and modelling of the ternary phase equilibria for high pressure carbon dioxide-ethanol-water mixtures. Fluid Phase Equilibria 2007, 252:103-113.
14. Bustami R.T., Chan H.-K., Dehghani F., Foster N.R. Generation of micro-particles of proteins for aerosol delivery using high pressure modified carbon dioxide. Pharmaceutical Research 2000, 17(11):1360-1366.
15. Bustami R.T., Chan H.-K., Sweeney T., Dehghani F., Foster N.R. Generation of fine powders of recombinant human deoxyribonuclease using the aerosol solvent extraction system. Pharmaceutical Research 2003, 20(12):2028-2035.
16. Jovanović N., Bouchard A., Hofland G.W., Witkamp G.-J., Crommelin D.J.A., Jiskoot W. Stabilization of proteins in dry powder formulations using supercritical fluid technology. Pharmaceutical Research 2004, 21(11):1955-1969.
17. Bouchard A., Jovanović N., Jiskoot W., Mendes E., Witkamp G-J., Crommelin D.J.A., Hofland G.W. Lysozyme particle formation during supercritical fluid drying: particle morphology and molecular integrity. Journal of Supercritical Fluids 2007, 40:293-307.
18. Bouchard A., Jovanović N., Martín A., Hofland G.W., Crommelin D.J.A., Jiskoot W., Witkamp G.-J. Effect of the modifier on the particle formation and crystallization behaviour during precipitation from aqueous solutions. Journal of Supercritical Fluids 2008, 44:409-421.
19. Bleustein C.B., Sennett M., Kung R.T.V., Felsen D., Poppas D.P., Stewart R.B. Differential scanning calorimetry of albumin solders: interspecies differences and fatty acid binding effects on protein denaturation. Lasers in Surgery and Medicine 2000, 27:465-470.
20. Reverchon E., De Marco I. Supercritical antisolvent micronization of Cefonicid: thermodynamic interpretation of results. Journal of Supercritical Fluids 2004, 31:207-215.
21. Reverchon E., De Marco I. Supercritical antisolvent precipitation of Cephalosporins. Powder Technology 2006, 164:139-146.
22. De Marco I., Reverchon E. Supercritical antisolvent micronization of cyclodextrins. Powder Technology 2008, 183:239-246.
23. Adami R., Reverchon E., Järvenpää E., Huopalahti R. Supercritical antisolvent micronization of nalmefene HCl on laboratory and pilot scale. Powder Technology 2008, 182:105-112.
24. Reverchon E., Caputo G., De Marco I. Role of phase behavior and atomization in the supercritical antisolvent precipitation. Industrial & Engineering Chemistry Research 2003, 42:6406-6414.
25. Dekker J.P., van der Put P.J., Veringa H.J., Schoonman J. Gas-to-particle conversion in the particle precipitation-aided chemical vapor deposition process I. Synthesis of the binary compound titanium nitride. Aerosol Science and Technology 1993, 19:549-561.