Permanent contraception of dogs induced with intratesticular injection of a Zinc Gluconate-based solution

Theriogenology

Volumn 77, Issue 6, 2012, Pages 1056-1063

  Oliveira, Erika C S ^a   Moura, Maria Raquel P ^b   de Sá, Marcelo J C ^c   Silva, Valdemiro A ^a   Kastelic, John P ^d   Douglas, Robert H ^e   Marques, Antônio P ^b  

^a UNIVERSIDADE FEDERAL RURAL DE PERNAMBUCO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c FEDERAL UNIVERSITY OF CAMPINA GRANDE   (Brazil)

^d AGRICULTURE AND AGRI FOOD CANADA   (Canada)

^e BET Labs   (United States)

Author keywords

Contraception; Dog; Semen; Sterilization; Testis; Zinc Gluconate

Indexed keywords

GLUCONIC ACID; MALE CONTRACEPTIVE AGENT; TESTOSTERONE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; CLINICAL TRIAL; CONTRACEPTION; DRUG EFFECT; HISTOLOGY; INJECTION; LIBIDO; MALE; METHODOLOGY; SPERMATOGENESIS; TESTIS;

ANIMALS; CONTRACEPTIVE AGENTS, MALE; GLUCONATES; INJECTIONS; LIBIDO; MALE; SPERMATOGENESIS; STERILIZATION, REPRODUCTIVE; TESTIS; TESTOSTERONE;

CANIS FAMILIARIS;

EID: 84857798065     PISSN: 0093691X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theriogenology.2011.10.008     Document Type: Article

References (26)

1. Concannon P.W. Contraception in the dog. Vet Ann 1995, 35:177-187.
2. Neutersol W.M. From laboratory to market. Second International Symposium on Non-Surgical Methods for Pet Population Control 2004, 165-169.
3. Neutersol W.M. Intratesticular injection induces sterility in dogs. International Symposium on Non-Surgical Methods for Pet Population Control 2002, 62-65.
4. Levy J. Neutersol in the Galapagos: Lessons learned. Third Int Symp Nonsurg Methods Pet Populations Control 2006, Session V.
5. LaCroix C.E. Evaluation of a single intratesticular injection of zinc gluconate neutralized by arginine (Neutersol) as a chemical sterilant in sexually mature, male dogs. Third Int Symp Nonsurg Methods Pet Populations Control 2006, Session V6.
6. Oliveira E.C.S., Moura M.R., Silva V.A., Peixoto C.A., Saraiva K.L.A., Sá M.J.C., et al. Intratesticular injection of a zinc-based solution as a contraceptive for dogs. Theriogenology 2007, 68:137-145.
7. Soto F.R.M., Viana W.G., Mucciolo G.C.B., Hosomi F.Y.M., Vanucchi C.I., Mazzei C.P., et al. Evaluation of efficacy and safety of zinc gluconato associated with dimethyl sulphoxide for sexually mature canine males chemical neutering. Reprod Dom Anim 2009, 44:927-931.
8. Fahim M.S., Wang M., Sutcu M.F., Fahim Z., Yougquist R.S. Sterilization of dogs with intra-epididymal injection of zinc arginine. Contraception 1993, 47:107-122.
9. Purswell B.J., Jochle W. Targets and historical approaches to non-surgical sterilization in dogs and cats. The Fourth International Symposium on Non-Surgical Methods for Pet Population Control 2010, 84-88.
10. Santos S.E.C. Avaliação dos perfis andrológicos e polimorfismo no gene do receptor do hormÔnio luteinizante (LH) de cães da raça Dogue Alemão [Evaluation of andrologic profile and polymorphism of the luteinizing hormone gene receptor in Great Dane dogs]. Tese (Doutorado) - Faculdade de Medicina Veterinária e Zootecnia 2001, 126. Universidade de São Paulo, São Paulo.
11. Allen M.J., Hoffmann W.E., Richardson, Breur G.J. Serum markers of bone metabolism in dogs. Am J Vet Res 1998, 59:250-254.
12. Silva F.L.M., Brito L.T., Muller P.M., Araújo B., Sá M.J.C., Silva Junior V.A., et al. Sterilization of dogs with intratesticular injection of a zinc based solution - Histopathological evaluation of acute and chronic phase. Third Int Symp Anim Reprod 2010, 230.
13. Saraiva K.L.A., Silva V.A., Dias E.S.F., Peixoto C.A. Morphological changes in the testis induced by diethylcarbamazine. Reprod Toxicol 2006, 22:74-79.
14. Souza F.F., Leme D.P., Uechi E., Trinca L.A., Lopes M.D. Evaluation testicular fine needle aspiration cytology and serum testosterone levels in dogs. Braz J Vet Res Anim Sci 2004, 41:98-105.
15. Ortega-Pacheco A., Segura-Correa J.C., Boli-Gonzales M.E., Jiménez-Coello M., Linde-Forsberg C. Reproductive patterns of stray male dogs in the tropics. Theriogenology 2006, 66:2084-2090.
16. Munson L., Chassy L.M., Asa C. Efficacy, safety and reversibility of bisdiamine as a male contraceptive in cats. Theriogenology 2004, 62:81-92.
17. Neilson J.C., Eckstein R.A., Hart B.L. Effects of castration on problem behaviors in male dogs with reference to age and duration of behavior. J Am Vet Med Assoc 1997, 211:180-182.
18. Hopkins S.G., Schubert T.A., Hart B.L. Castration of adult male dogs: Effects on roaming, aggression, urine marking, and mounting. J Am Vet Med Assoc 1976, 168:1108-1110.
19. Maarschalkerweerd R.J., Endenburg N., Kirpensteijn J., Knol B.W. Influence of orchiectomy on canine behaviour. Vet Rec 1997, 14:617-619.
20. Neutersol H.C. Chemical sterilization for dogs. Caribbean Animal Welfare Conference. Best Practices in Humane Control Stray and Feral Dog and Cat Population 2004, 20-25.
21. Tepsumethanon V., Wilde H., Hemachudha T. Intratesticular injection of a balanced zinc solution for permanent sterilization of dogs. J Med Assoc Thai 2005, 88:686-689.
22. Soto F.R.M., Viana W.G., Sousa A.J., Pinheiro S.R., Mucciolo G.B., Hosomi F.Y.M., et al. Evaluation of zinc gluconate, either associated or not to dimethyl sulphoxide as contraceptive method for male dogs. Anim Reprod 2007, 4:119-124.
23. Lorena S.E.R.S., Luna S.P.L., Rodrigues D., Lima A.F. Avaliação álgica do gluconato de zinco injetado por via intratesticular para a contracepção química em cães. [Pain evaluation of intratesticular injection of zinc gluconate for chemical contraception in dogs] FMVZ, UNESP, Botucatu, Accessed: April 19, 2011. http://www.infertile.com.br.
24. Hidiroglou M., Knipfel J.E. Zinc in mammalian sperm: A review. J Dairy Sci 1984, 67:1147-1156.
25. Toxicological Profiles for Zinc 2005, U.S. Department of Health and Human Services. Agency for Toxic Substances and Disease Registry, Atlanta.
26. Levy J.K., Crawford P.C., Appel L.D., Clifford E.L. Comparison of intratesticular injection of zinc gluconate versus surgical castration to sterilize male dogs. Am J Vet Res 2008, 69:140-143.