Nandrolone inhibits MMP-2 in the left ventricle of rats

International Journal of Sports Medicine

Volumn 33, Issue 3, 2012, Pages 181-185

  Marqueti, R C ^a   Micocci, K C ^a   Leite, R D ^a   Selistre De Araujo, H S ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

Author keywords

androgenic anabolic steroid; left ventricle; matrix metallopeptidases; mechanical load exercise

Indexed keywords

ANABOLIC AGENT; DRUG DERIVATIVE; GELATINASE A; NANDROLONE; NANDROLONE DECANOATE;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HEART VENTRICLE; MALE; RAT; WESTERN BLOTTING; WISTAR RAT;

ANABOLIC AGENTS; ANIMALS; BLOTTING, WESTERN; HEART VENTRICLES; MALE; MATRIX METALLOPROTEINASE 2; NANDROLONE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR;

EID: 84857791141     PISSN: 01724622     EISSN: 14393964     Source Type: Journal    
DOI: 10.1055/s-0031-1291252     Document Type: Article

References (38)

1. Ahlgrim C, Guglin M. Anabolics and cardiomyopathy in a bodybuilder: case report and literature review. J Card Fail: 2009; 15 496 500
2. Ahmed S H, Clark L L, Pennington W R, Webb C S, Bonnema D D, Leonardi A H, McClure C D, Spinale F G, Zile M R. Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease. Circulation: 2006; 113 2089 2096
3. Baggish A L, Weiner R B, Kanayama G, Hudson J I, Picard M H, Hutter A M Jr, Pope H G Jr. Long-term anabolic-androgenic steroid use is associated with left ventricular dysfunction. Circ Heart Fail: 2010; 3 472 476
4. Bergman M R, Teerlink J R, Mahimkar R, Li L, Zhu B Q, Nguyen A, Dahi S, Karliner J S, Lovett D H. Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction. Am J Physiol: 2007; 292 H1847 H1860 (Pubitemid 46572408)
5. Casavant M J, Blake J, Griffith A, Yates A, Copley L M. Consequences of use on anabolic androgenic steroids. Pediatric Clin North Am: 2007; 54 677 690 (Pubitemid 47302016)
6. Cheung P Y, Sawicki G, Wozniak M, Wang W, Radomski M W, Schulz R. Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart. Circulation 18: 2000; 101 1833 1839 (Pubitemid 30213106)
7. Cleutjens JP M, Kandala J C, Guarda E, Guntaka R V, Weber K T. Regulation of collagen degradation in rat myocardium after infartion. J Mol Cell Cardiol: 1995; 27 1281 1292
8. Cunha T S, Tanno A P, Costa Sampaio Moura M J, Marcondes F K. Influence of high intensity training and anabolic steroids treatment on rat tissue glycogen content. Life Sci: 2005; 77 1030 1043 (Pubitemid 40814638)
9. DAndrea A, Caso P, Salerno G, Scarafile R, De Corato G, Mita C, Di Salvo G, Severino S, Cuomo S, Liccardo B, Esposito N, Calabro R. Left ventricular early myocardial dysfunction after chronic misuse of anabolic androgenic steroids: a Doppler myocardial and strain imaging analysis. Br J Sports Med: 2007; 41 149 155 (Pubitemid 46579900)
10. Dhar R, Stout C W, Link M S, Homoud M K, Weinstock J, Estes N A 3rd. Cardiovascular toxicities of performance-enhancing substances in sports. Mayo Clin Proc: 2005; 80 1307 1315 (Pubitemid 41395964)
11. Dollery C M, McEwan J R, Henney A M. Matrix metalloproteinases and cardiovascular disease. Circ Res: 1995; 77 863 868
12. Godon P, Bonnefoy E, Gurard S, Munet M, Velon S, Brion R, Touboul P. Myocardial infarction and anabolic steroid use. A case report. Arch Mal Coeur Vaiss: 2000; 93 879 883 (Pubitemid 30616575)
13. Halvorsen S, Thorsby P M, Haug E. Acute myocardial infarction in a young man who had been using androgenic anabolic steroids. Tidsskr Nor Laegeforen: 2004; 124 170 172 (Pubitemid 38279622)
14. Harriss D J, Atkinson G. Update - Ethical Standards in Sport and Exercise Science Research. Int J Sports Med: 2011; 32 819 821
15. Hartgens F, Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports Med: 2004; 34 513 554 (Pubitemid 38981844)
16. Hausmann R, Hammer S, Betz P. Performance enhancing drugs (doping agents) and sudden death - a case report and review of the literature. Int J Legal Med: 1998; 111 261 264 (Pubitemid 28381427)
17. Herity N A, Ward M R, Lo S, Yeung A C. Review: clinical aspects of vascular remodeling. J Cardiovasc Electrophysiol: 1999; 10 1016 1024 (Pubitemid 29297721)
18. Janssens S, Lijnen H R. What has been learned about the cardiovascular effects of matrix mettaloproteinases from mouse models? Cardiovasc Res: 2006; 69 585 594 (Pubitemid 43139722)
19. Krieg A, Scharhag J, Albers T, Kindermann W, Urhausen A. Cardiac tissue Doppler in steroid users. Int J Sports Med: 2007; 28 638 643 (Pubitemid 47305269)
20. Kukacka J, Prsa R, Kotaska K, Pelouch V. Matrix metalloproteinases and their function in myocardium. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub: 2005; 149 225 236
21. Lau D H, Stiles M K, John B. Shashidhar Young G D, Sanders P. Atrial brillation and anabolic steroid abuse. Int J Cardiol: 2007; 117 86 87
22. Liu P Y, Death A K, Handelsman D J. Androgens and cardiovascular disease. Endocr Rev: 2003; 24 313 340 (Pubitemid 36724373)
23. Lyngberg K K. Myocardial infarction and death of a body builder after using anabolic steroids. Ugeskr Laeger: 1991; 153 587 588
24. Marqueti R C, Parizotto N A, Chriguer R S, Perez SE A, Selistre-de-Araujo H S. Androgenic-anabolic steroids associated with mechanical loading inhibit matrix metallopeptidase activity and affect the remodeling of the achilles tendon in rats. Am J Sport Med: 2006; 34 1274 1280 (Pubitemid 44050213)
25. Marqueti R C, Prestes J, Stotzer U S, Paschoal M, Leite R D, Perez S E, Selistre de Araujo H S. MMP-2 jumping exercise and nandrolone in skeletal muscle. Int J Sports Med: 2007; 29 559 563
26. Marqueti R C, Prestes J, Wang C C, Ramos O H, Perez S E, Nakagaki W R, Carvalho H F, Selistre-de-Araujo H S. Biomechanical responses of different rat tendons to nandrolone decanoate and load exercise. Scand J Med Sci Sports: 2010; Jul 29. [Epub ahead of print]. PMID: 20673248
27. Marqueti R C, Prestes J, Paschoal M, Ramos O H, Perez S E, Carvalho H F, Selistre-de-Araujo H S. Matrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids. Eur J Appl Physiol: 2008; 104 1087 1093
28. Marsolais D, Duchesne E, Ct C H, Frenette J. Inflammatory cells do not decrease the ultimate tensile strength of intact tendons in vivo and in vitro: protective role of mechanical loading. J Appl Physiol: 2007; 102 11 17 (Pubitemid 46089746)
29. Nieminen M S, Rämö M P, Viitasalo M, Heikkilä P, Karjalainen J, Mäntysaari M, Heikkilä J. Serious cardiovascular side effects of large doses of anabolic steroids in weight lifters. Eur Heart J: 1996; 17 1576 1583 (Pubitemid 26345149)
30. Paschoal M, de Cssia Marqueti R, Perez S, Selistre-de-Araujo H S. Nandrolone inhibits VEGF mRNA in rat muscle. Int J Sports Med: 2009; 30 775 778
31. Pereira-Junior P P, Chaves E A, Costa-E-Sousa R H, Masuda M O, de Carvalho A C, Nascimento J H. Cardiac autonomic dysfunction in rats chronically treated with anabolic steroid. Eur J Appl Physiol: 2006; 96 487 494
32. Pope H G Jr, Katz D L. Affective and psychotic symptoms associated with anabolic steroids use. Am J Psychiat: 1988; 145 487 490 (Pubitemid 18099129)
33. Prior B M, Lloyd P G, Yang H T, Terjung R L. Exercise-induced vascular remodeling. Exerc Sport Sci Rev: 2003; 31 26 33 (Pubitemid 36158008)
34. Rocha F L, Carmo E C, Roque F R, Hashimoto N Y, Rossoni L V, Frimm C, Anas I, Negro C E, Krieger J E, Oliveira E M. Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats. Am J Physiol: 2007; 293 H3575 H3583 (Pubitemid 350230902)
35. Sullivan M L, Martinez C M, Gennis P, Gallagher E J. The cardiac toxicity of anabolic steroids. Prog Cardiovasc Dis: 1998; 41 1 15 (Pubitemid 28385246)
36. Thiblin I, Petersson A. Pharmacoepidemiology of anabolic androgenic steroids: a review. Fundam Clin Pharmacol: 2005; 19 27 44 (Pubitemid 40204345)
37. Van Linthout S, Seeland U, Riad A, Eckhardt O, Hohl M, Dhayat N, Richter U, Fischer J W, Böhm M, Pauschinger M, Schultheiss H P, Tschöpe C. Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy. Basic Res Cardiol: 2008; 103 319 327
38. Xu X, Wan W, Powers A S, Li J, Ji L L, Lao S, Wilson B, Erikson J M, Zhang J Q. Effects of exercise training on cardiac function and myocardial remodeling in post myocardial infarction rats. J Mol Cell Cardiol: 2008; 44 114 122