The effects of moxaverine on ocular blood flow in patients with age-related macular degeneration or primary open angle glaucoma and in healthy control subjects

Acta Ophthalmologica

Volumn 90, Issue 2, 2012, Pages 139-145

  Pemp, Berthold ^a   Garhofer, Gerhard ^a   Lasta, Michael ^a   Schmidl, Doreen ^a   Wolzt, Michael ^a   Schmetterer, Leopold ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

age related macular degeneration; blood flow; moxaverine; open angle glaucoma

Indexed keywords

MOXAVERINE;

AGED; ARTICLE; BLOOD FLOW VELOCITY; CILIARY ARTERY; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIZZINESS; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; EYE BLOOD FLOW; FEMALE; HEAT; HUMAN; INTRAOCULAR PRESSURE; MALE; OPEN ANGLE GLAUCOMA; OPHTHALMIC ARTERY; OPTIC NERVE; PRIORITY JOURNAL; RETINA ARTERY; RETINA BLOOD VESSEL; RETINA MACULA AGE RELATED DEGENERATION; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; VEIN DIAMETER;

AGED; BLOOD FLOW VELOCITY; CHOROID; CILIARY ARTERIES; FEMALE; GLAUCOMA, OPEN-ANGLE; HUMANS; INFUSIONS, INTRAVENOUS; LASER-DOPPLER FLOWMETRY; MACULAR DEGENERATION; MALE; OPHTHALMIC ARTERY; OPTIC DISK; PAPAVERINE; PARASYMPATHOLYTICS; PHOSPHODIESTERASE INHIBITORS; REGIONAL BLOOD FLOW; RETINAL VESSELS;

EID: 84857734761     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/j.1755-3768.2010.01878.x     Document Type: Article

References (46)

1. Age-Related Eye Disease Study Research Group (2001): A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 119: 1417-1436.
2. Berg G, Andersson RG, &, Ryden G, (1987): Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study. Arch Int Pharmacodyn Ther 290: 288-292.
3. Berndt SF, Schulz HU, &, Stock K, (1976): Influence of papaverine derivatives on phosphodiesterase activity, cyclic 3′,5′-AMP levels and relaxing effect on rabbit ileum. Naunyn Schmiedebergs Arch Pharmacol 294: 271-275.
4. Bonner R, &, Nossal R, (1990): Principles of laser-Doppler flowmetry. In:, Sheperd AP, &, Öberg PÅ, (eds). Laser-Doppler blood flowmetry. Vol. 107 of developments in cardiovascular medicine. Boston: Kluwer Academic Publishers, 17-45.
5. Chung HS, Harris A, Kristinsson JK, Ciulla TA, Kagemann C, &, Ritch R, (1999): Ginkgo biloba extract increases ocular blood flow velocity. J Ocul Pharmacol Ther 15: 233-240. (Pubitemid 29262980)
6. Ciulla TA, Harris A, &, Martin BJ, (2001): Ocular perfusion and age-related macular degeneration. Acta Ophthalmol Scand 79: 108-115. (Pubitemid 32258178)
7. Ciulla TA, Harris A, Latkany P, Piper HC, Arend O, Garzozi H, &, Martin B, (2002): Ocular perfusion abnormalities in diabetes. Acta Ophthalmol Scand 80: 468-477. (Pubitemid 35243850)
8. Feine-Haake G, Neiss A, &, Weinert W, (1975): The treatment of cerebrovascular insufficiency. Their evaluation in a doubleblind study. MMW Munch Med Wochenschr 117: 1131-1132.
9. Flammer J, Pache M, &, Resink T, (2001): Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye. Prog Retin Eye Res 20: 319-349. (Pubitemid 32245685)
10. Flammer J, Orgül S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard JP, &, Stefánsson E, (2002): The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 21: 359-393. (Pubitemid 34879080)
11. Garhofer G, Bek T, Boehm AG, et al., (2009): Use of the retinal vessel analyzer in ocular blood flow research. Acta Ophthalmol [Epub ahead of print].
12. Gaspar AZ, Gasser P, &, Flammer J, (1995): The influence of magnesium on visual field and peripheral vasospasm in glaucoma. Ophthalmologica 209: 11-13.
13. Grunwald JE, Siu KK, Jacob SS, &, Dupont J, (2001): Effect of sildenafil citrate (Viagra) on the ocular circulation. Am J Ophthalmol 131: 751-755. (Pubitemid 32522645)
14. Harris A, Jonescu-Cuypers C, Martin B, Kagemann L, Zalish M, &, Garzozi HJ, (2001): Simultaneous management of blood flow and IOP in glaucoma. Acta Ophthalmol Scand 79: 336-341. (Pubitemid 32677802)
15. Harris A, Kagemann L, Ehrlich R, Ehrlich Y, López CR, &, Purvin VA, (2008): The effect of sildenafil on ocular blood flow. Br J Ophthalmol 92: 469-473. (Pubitemid 351497970)
16. Kerr NM, &, Danesh-Meyer HV, (2009): Phosphodiesterase inhibitors and the eye. Clin Experiment Ophthalmol 37: 514-523.
17. Koksal M, Ozdemir H, Kargi S, Yesilli C, Tomaç S, Mahmutyazicioglu K, &, Mungan A, (2005): The effects of sildenafil on ocular blood flow. Acta Ophthalmol Scand 83: 355-359. (Pubitemid 40872511)
18. Konno T, Uchibori T, Nagai A, Kogi K, &, Nakahata N, (2007): Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits. Life Sci 80: 1115-1122. (Pubitemid 46241216)
19. Koseki N, Araie M, Tomidokoro A, Nagahara M, Hasegawa T, Tamaki Y, &, Yamamoto S, (2008): A placebo-controlled 3-year study of a calcium blocker on visual field and ocular circulation in glaucoma with low-normal pressure. Ophthalmology 115: 2049-2057.
20. Lee KC, Silver PJ, Bode DC, &, Gherezghiher T, (1993): Ocular effects of topical administration of the phosphodiesterase III inhibitor milrinone in rabbits and cats. Methods Find Exp Clin Pharmacol 15: 527-534. (Pubitemid 24015832)
21. Lesk MR, Wajszilber M, &, Deschenes MC, (2008): The effects of systemic medications on ocular blood flow. Can J Ophthalmol 43: 351-355.
22. Lieb WE, Cohen SM, Merton DA, Shields JA, Mitchell DG, &, Goldberg BB, (1991): Color Doppler imaging of the eye and the orbit. Technique and normal vascular anatomy. Arch Ophthalmol 109: 527-531.
23. Lindemann H, (1972): Infusionsbehandlung diabetischer Stoffwechselstörungen des Auges. Klin Monatsbl Augenheilkd 161: 100-103.
24. Luksch A, Rainer G, Koyuncu D, Ehrlich P, Maca T, Gschwandtner ME, Vass C, &, Schmetterer L, (2005): Effect of nimodipine on ocular blood flow and colour contrast sensitivity in patients with normal tension glaucoma. Br J Ophthalmol 89: 21-25. (Pubitemid 40040232)
25. Luksch A, Lasta M, Polak K, Fuchsjäger-Mayrl G, Polska E, Garhöfer G, &, Schmetterer L, (2008): Twelve-hour reproducibility of retinal and optic nerve blood flow parameters in healthy individuals. Acta Ophthalmol 87: 875-880.
26. Mannhold R, (1988): Inhibition of calmodulin dependent c-AMP-phosphodiesterase by moxaverine and papaverine. Arzneimittelforschung 38: 1806-1808. (Pubitemid 19012524)
27. Metelitsina TI, Grunwald JE, Dupont JC, &, Ying GS, (2005): Effect of Viagra on the foveolar choroidal circulation of AMD patients. Exp Eye Res 81: 159-164. (Pubitemid 41080097)
28. Miwa T, Mori A, Nakahara T, &, Ishii K, (2009): Intravenously administered phosphodiesterase 4 inhibitors dilate retinal blood vessels in rats. Eur J Pharmacol 602: 112-116.
29. Nordeck H, Eichler K, Mulch R, &, Völker D, (1971): Collateral dilatation therapy in coronary and peripheral arterial occlusive diseases. Experimental and clinical experiences with 1-benzyl-3-ethyl-6,7- dimethoxyisoquinoline hydrochloride (BEN). Munch Med Wochenschr 113: 1006-1011.
30. Paris G, Sponsel WE, Sandoval SS, Elliott WR, Trigo Y, Sanford DK, &, Harison JM, (2001): Sildenafil increases ocular perfusion. Int Ophthalmol 23: 355-358. (Pubitemid 34256602)
31. Pemp B, &, Schmetterer L, (2008): Ocular blood flow in diabetes and age-related macular degeneration. Can J Ophthalmol 43: 295-301.
32. Polak K, Dorner G, Kiss B, Polska E, Findl O, Rainer G, Eichler HG, &, Schmetterer L, (2000): Evaluation of the Zeiss retinal vessel analyser. Br J Ophthalmol 84: 1285-1290.
33. Polak K, Wimpissinger B, Berisha F, Georgopoulos M, &, Schmetterer L, (2003): Effects of sildenafil on retinal blood flow and flicker-induced retinal vasodilatation in healthy subjects. Invest Ophthalmol Vis Sci 44: 4872-4876. (Pubitemid 37315303)
34. Polska E, Polak K, Luksch A, Fuchsjager-Mayrl G, Petternel V, Findl O, &, Schmetterer L, (2004): Twelve hour reproducibility of choroidal blood flow parameters in healthy subjects. Br J Ophthalmol 88: 533-537. (Pubitemid 38437876)
35. Pournaras CJ, Rungger-Brändle E, Riva CE, Hardarson SH, &, Stefansson E, (2008): Regulation of retinal blood flow in health and disease. Prog Retin Eye Res 27: 284-330.
36. Resch H, Weigert G, Karl K, Pemp B, Garhofer G, &, Schmetterer L, (2008): Effect of systemic moxaverine on ocular blood flow in humans. Acta Ophthalmol [Epub ahead of print].
37. Resch H, Karl K, Weigert G, Wolzt M, Hommer A, Schmetterer L, &, Garhöfer G, (2009): Effect of dual endothelin receptor blockade on ocular blood flow in patients with glaucoma and healthy subjects. Invest Ophthalmol Vis Sci 50: 358-363.
38. Riva CE, Grunwald JE, Sinclair SH, &, O'keefe K, (1981): Fundus camera based retinal LDV. Appl Opt 20: 117-120. (Pubitemid 11135728)
39. Riva CE, Grunwald JE, Sinclair SH, &, Petrig BL, (1985): Blood velocity and volumetric flow rate in human retinal vessels. Invest Ophthalmol Vis Sci 26: 1124-1132. (Pubitemid 15003355)
40. Riva CE, Harino S, Petrig BL, &, Shonat RD, (1992): Laser Doppler flowmetry in the optic nerve. Exp Eye Res 55: 499-506.
41. Riva CE, Cranstoun SD, Grunwald JE, &, Petrig BL, (1994): Choroidal blood flow in the foveal region of the human ocular fundus. Invest Ophthalmol Vis Sci 35: 4273-4281. (Pubitemid 24377498)
42. Riva CE, Geiser M, &, Petrig BL,; For the Ocular Blood Flow Research Association (2009): Ocular blood flow assessment using continuous laser Doppler flowmetry. Acta Ophthalmol [Epub ahead of print].
43. Schmid-Schonbein H, Schroder S, Grebe R, Artmann G, Eschweiler H, &, Teitel P, (1988): Influence of moxaverine hydrochloride on membrane curvature and microsieve filterability of red cells after exposure to hyperosmolarity and lactacidosis. Arzneimittelforschung 38: 710-716.
44. Siesky B, Harris A, Brizendine E, Marques C, Loh J, Mackey J, Overton J, &, Netland P, (2009): Literature review and meta-analysis of topical carbonic anhydrase inhibitors and ocular blood flow. Surv Ophthalmol 54: 33-46.
45. Tukey JW, Ciminera JL, &, Heyse JF, (1985): Testing the statistical certainty of a response to increasing doses of a drug. Biometrics 41: 295-301.
46. Uchida H, Tomita G, Hoshina F, Mochizuki N, &, Kitazawa Y, (2002): The effect of phosphodiesterase type 3 inhibitor on chorio-retinal blood flow in rabbits eyes. Nippon Ganka Gakkai Zasshi 106: 615-620.