Iron deficiency does not compromise the diagnosis of high HbA 2 β thalassemia trait

Haematologica

Volumn 97, Issue 3, 2012, Pages 472-473

  Passarello, Cristina ^a   Giambona, Antonino ^a   Cannata, Monica ^a   Vinciguerra, Margherita ^a   Renda, Disma ^a   Maggio, Aurelio ^a  

^a Azienda Ospedaliera Ospedali Riuniti 'Villa Sofia Cervello'   (Italy)

Author keywords

thalassemia; HbA 2 levels; Iron deficiency; Serum ferritin

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; FERRITIN; HEMOGLOBIN A2;

ANEMIA; BETA THALASSEMIA; BLOOD SAMPLING; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; FERRITIN BLOOD LEVEL; GENE MUTATION; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY; LETTER; LEUKOCYTE; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SCREENING TEST; SENSITIVITY AND SPECIFICITY; SINGLE NUCLEOTIDE POLYMORPHISM;

ANEMIA, IRON-DEFICIENCY; BETA-THALASSEMIA; FERRITINS; HEMOGLOBIN A2; HUMANS; IRON;

EID: 84857717112     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.052357     Document Type: Letter

References (9)

1. Giambona A, Passarello C, Renda D, Maggio A. The significance of the hemoglobin A(2) value in screening for hemoglobinopathies. Clin Biochem. 2009;42(18):1786-96.
2. Giambona A, Lo Gioco P, Marino M, Abate I, Di Marzo R, Renda M, et al. The great heterogeneity of thalassemia molecular defects in Sicily. Hum Genet. 1995;95(5):526-30.
3. Steinberg MH, Adams JG. Hemoglobin A2: Origin, evolution and aftermath. Blood. 1991;78(9):2165-77.
4. Harthoorn-Lasthuizen EJ, Lindemans J, Langenhuijsen MM. Influence of iron deficiency anaemia on haemoglobin A2 levels: possible consequences for beta-thalassaemia screening. Scand J Clin Lab Invest. 1999;59(1):65-70.
5. Madan N, Sikka M, Sharma S, Rusia U. Phenotypic expression of hemoglobin A2 in beta-thalassemia trait with iron deficiency. Ann Hematol. 1998;77(3):93-6.
6. Giambona A, Passarello C, Ruggeri G, Renda D, Teresi P, Anzà M, et al. Analysis of e-globin gene alleles in the Sicilian population: identification of five new mutations. Haematologica. 2006; 91(12):1684-7.
7. Mast AE, Blinderb MA, Gronowsky AM, Chumley C, Scott MG. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem. 1998; 44(1):45-51.
8. Giambona A, Passarello C, Vinciguerra M, Li Muli R, Teresi P, Anzà M, et al. Significance of borderline hemoglobin A2 values in an Italian population with a high prevalence of I-thalassemia. Haematologica. 2008;93(9):1380-4.
9. Alperin JB, Dow BS, Petteway BS. Hemoglobin A2 levels in health and various hematologic disorders. Am J Clin Pathol. 1977; 67(3):219-26.