Abnormal inflammation leads to maternal coagulopathies associated with placental haemostatic alterations in a rat model of foetal loss

Thrombosis and Haemostasis

Volumn 107, Issue 3, 2012, Pages 438-447

  Falcón, Bani J ^a   Cotechini, Tiziana ^a   Macdonald Goodfellow, Shannyn K ^a   Othman, Maha ^a   Graham, Charles H ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Coagulopathy; Haemodynamics; Inflammation; Pregnancy loss; Rat

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ETANERCEPT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMICROSCOPY; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISSEMINATED INTRAVASCULAR CLOTTING; FEMALE; FETUS WASTAGE; FIBRIN DEPOSITION; HEMOSTASIS; HISTOLOGY; HYPERCOAGULABILITY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MATERNAL DISEASE; NONHUMAN; PLACENTA; PRIORITY JOURNAL; RAT; THROMBOELASTOGRAPHY;

ABORTION, SPONTANEOUS; ANIMALS; DISEASE MODELS, ANIMAL; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; HEMOSTASIS; HUMANS; IMMUNOGLOBULIN G; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; RATS; RATS, WISTAR; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84857710221     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH11-09-0626     Document Type: Article

References (35)

1. Brenner B. Hypercoagulability and recurrent miscarriages. Clin Adv Hematol Oncol 2010; 8: 467-469.
2. Sarig G, Younis JS, Hoffman R, et al. Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage. Fertil Steril 2002; 77: 342-347.
3. Kwak-Kim J, Park JC, Ahn HK, et al. Immunological modes of pregnancy loss. Am J Reprod Immunol 2010; 63: 611-623.
4. Kwak-Kim J, Yang KM, Gilman-Sachs A. Recurrent pregnancy loss: a disease of inflammation and coagulation. J Obstet Gynaecol Res 2009; 35: 609-622.
5. Laskin CA, Chuma A, Angelov L, et al. Sera from habitual aborters induce monocyte procoagulant activity: a lymphocyte-dependent event. Clin Immunol Immunopathol 1994; 73: 235-244.
6. Babbage SJ, Arkwright PD, Vince GS, et al. Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss. J Reprod Immunol 2001; 51: 21-27.
7. Ng SC, Gilman-Sachs A, Thaker P, et al. Expression of intracellular Th1 and Th2 cytokines in women with recurrent spontaneous abortion, implantation failures after IVF/ET or normal pregnancy. Am J Reprod Immunol 2002; 48: 77-86.
8. Raghupathy R. Th1-type immunity is incompatible with successful pregnancy. Immunol Today 1997; 18: 478-482.
9. Raghupathy R, Makhseed M, Azizieh F, et al. Maternal Th1-and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions. Cell Immunol 1999; 196: 122-130.
10. Berman J, Girardi G, Salmon JE. TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss. J Immunol 2005; 174: 485-490.
11. Silver RM, Lohner WS, Daynes RA, et al. Lipopolysaccharide-induced fetal death: the role of tumor-necrosis factor alpha. Biol Reprod 1994; 50: 1108-1112.
12. Renaud SJ, Cotechini T, Quirt JS, et al. Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion. J Immunol 2011; 186: 1799-1808.
13. Brenner B, Aharon A. Thrombophilia and adverse pregnancy outcome. Clin Perinatol 2007; 34: 527-541, v.
14. Benedetto C, Marozio L, Tavella AM, et al. Coagulation disorders in pregnancy: acquired and inherited thrombophilias. Ann NY Acad Sci 2010; 1205: 106-117.
15. Carp HJ. Thrombophilia and recurrent pregnancy loss. Obstet Gynecol Clin North Am 2006; 33: 429-442.
16. De Wolf F, Carreras LO, Moerman P, et al. Decidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant. Am J Obstet Gynecol 1982; 142: 829-834.
17. Kramer MS, Usher RH, Pollack R, et al. Etiologic determinants of abruptio placentae. Obstet Gynecol 1997; 89: 221-226.
18. Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat Rev Immunol 2008; 8: 776-787.
19. Thachil J, Toh CH. Disseminated intravascular coagulation in obstetric disorders and its acute haematological management. Blood Rev 2009; 23: 167-176.
20. Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med 1999; 341: 586-592.
21. Vincent T, Rai R, Regan L, et al. Increased thrombin generation in women with recurrent miscarriage. Lancet 1998; 352: 116.
22. Woodhams BJ, Candotti G, Shaw R, et al. Changes in coagulation and fibrinolysis during pregnancy: evidence of activation of coagulation preceding spontaneous abortion. Thromb Res 1989; 55: 99-107.
23. Othman M, Powell S, Chirinian Y, et al. Thromboelastography reflects global hemostatic variation among severe haemophilia A dogs at rest and following acute exercise. Haemophilia 2009; 15: 1126-1134.
24. Filler SG, Solis NV, Guo J, et al. Pharmacokinetics of murine p75-Fc fusion protein and MP6-XT22 anti-murine TNF-alpha mAb in mice. J Investig Dermatol Symp Proc 2007; 12: 52-56.
25. Brenner B, Sarig G, Weiner Z, et al. Thrombophilic polymorphisms are common in women with fetal loss without apparent cause. Thromb Haemost 1999; 82: 6-9.
26. Stirling Y, Woolf L, North WR, et al. Haemostasis in normal pregnancy. Thromb Haemost 1984; 52: 176-182.
27. Bremme KA. Haemostatic changes in pregnancy. Best Pract Res Clin Haematol 2003; 16: 153-168.
28. Fust G, Bertok L, Juhasz-Nagy S. Interactions of radio-detoxified Escherichia coli endotoxin preparations with the complement system. Infect Immun 1977; 16: 26-31.
29. Kobayashi T, Sumimoto K, Tokunaga N, et al. Coagulation index to distinguish severe preeclampsia from normal pregnancy. Semin Thromb Hemost 2002; 28: 495-500.
30. Rousseau A, Favier R, Van Dreden P. Elevated circulating soluble thrombomodulin activity, tissue factor activity and circulating procoagulant phospholipids: new and useful markers for pre-eclampsia? Eur J Obstet Gynecol Reprod Biol 2009; 146: 46-49.
31. Asakura H, Suga Y, Aoshima K, et al. Marked difference in pathophysiology between tissue factor-and lipopolysaccharide-induced disseminated intravascular coagulation models in rats. Crit Care Med 2002; 30: 161-164.
32. Orlikowski CE, Rocke DA, Murray WB, et al. Thrombelastography changes in preeclampsia and eclampsia. Br J Anaesth 1996; 77: 157-161.
33. Dossenbach-Glaninger A, van Trotsenburg M, Krugluger W, et al. Elevated coagulation factor VIII and the risk for recurrent early pregnancy loss. Thromb Haemost 2004; 91: 694-699.
34. Iwaki T, Castellino FJ. Maternal fibrinogen is necessary for embryonic development. Curr Drug Targets 2005; 6: 535-539.
35. Rey E, Kahn SR, David M, et al. Thrombophilic disorders and fetal loss: a metaanalysis. Lancet 2003; 361: 901-908.