Exercise-induced intrapulmonary arteriovenous shunt in healthy women

Respiratory Physiology and Neurobiology

Volumn 181, Issue 1, 2012, Pages 8-13

  Kennedy, Jill M ^a   Foster, Glen E ^a   Koehle, Michael S ^a,b   Potts, James E ^a   Sandor, George G S ^a   Potts, M Terri ^a   Houghton, Kristin M ^a   Henderson, William R ^a   Sheel, A William ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Oxygen consumption; Saline contrast echocardiography; Semi recumbent cycle exercise

Indexed keywords

CARBON DIOXIDE;

ADULT; AEROBIC CAPACITY; AEROBIC EXERCISE; AGITATION; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTRAST ECHOCARDIOGRAPHY; CYCLING; DIASTOLIC BLOOD PRESSURE; EXERCISE INTENSITY; EXHAUSTION; FEMALE; FITNESS; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; MEAN ARTERIAL PRESSURE; OXYGEN CONSUMPTION; PATENT FORAMEN OVALE; PRIORITY JOURNAL; PULMONARY ARTERIOVENOUS FISTULA; RECUMBENCY; SYSTOLIC BLOOD PRESSURE;

ADULT; ARTERIOVENOUS ANASTOMOSIS; ECHOCARDIOGRAPHY; EXERCISE; EXERCISE TEST; FEMALE; HEART; HUMANS; LUNG; OXYGEN CONSUMPTION; PHYSICAL FITNESS;

EID: 84857704683     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2012.01.004     Document Type: Article

References (31)

1. Astrand P.O., Saltin B. Maximal oxygen uptake and heart rate in various types of muscular activity. J. Appl. Physiol. 1961, 16:977-981.
2. Attaran R.R., Ata I., Kudithipudi V., Foster L., Sorrell V.L. Protocol for optimal detection and exclusion of a patent foramen ovale using transthoracic echocardiography with agitated saline microbubbles. Echocardiography 2006, 23:616-622.
3. Cheney F.W., Pavlin J., Ferens J., Allen D. Effect of pulmonary microembolism on arteriovenous shunt flow. J. Thorac. Cardiovasc. Surg. 1978, 76:473-478.
4. Davis H.H., Schwartz D.J., Lefrak S.S., Susman N., Schainker B.A. Alveolar-capillary oxygen disequilibrium in hepatic cirrhosis. Chest 1978, 73:507-511.
5. Eldridge M.W., Dempsey J.A., Haverkamp H.C., Lovering A.T., Hokanson J.S. Exercise-induced intrapulmonary arteriovenous shunting in healthy humans. J. Appl. Physiol. 2004, 97:797-805.
6. George J.D., Stone W.J., Burkett L.N. Non-exercise VO2max estimation for physically active college students. Med. Sci. Sports Exerc. 1997, 29:415-423.
7. Harf A., Pratt T., Hughes J.M. Regional distribution of VA/Q in man at rest and with exercise measured with krypton-81m. J. Appl. Physiol. 1978, 44:115-123.
8. Harms C.A., McClaran S.R., Nickele G.A., Pegelow D.F., Nelson W.B., Dempsey J.A. Exercise-induced arterial hypoxaemia in healthy young women. J. Physiol. 1998, 507:619-628.
9. Hopkins S.R., Harms C.A. Gender and pulmonary gas exchange during exercise. Exerc. Sport Sci. Rev. 2004, 32:50-56.
10. Hopkins S.R., Olfert I.M., Wagner P.D. Point: exercise-induced intrapulmonary shunting is imaginary. J. Appl. Physiol. 2009, 107:993-994.
11. Jones R.L. It's too early for the shunt debate. J. Appl. Physiol. 2009, 107:999.
12. La Gerche A., Macisaac A.I., Burns A.T., Mooney D.J., Inder W.J., Voigt J.U., Heidbuchel H., Prior D.L. Pulmonary transit of agitated contrast is associated with enhanced pulmonary vascular reserve and right ventricular function during exercise. J. Appl. Physiol. 2010, 109:1307-1317.
13. Laurie S.S., Yang X., Elliott J.E., Beasley K.M., Lovering A.T. Hypoxia-induced intrapulmonary arteriovenous shunting at rest in healthy humans. J. Appl. Physiol. 2010, 109:1072-1079.
14. Lovering A.T., Romer L.M., Haverkamp H.C., Pegelow D.F., Hokanson J.S., Eldridge M.W. Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humans. J. Appl. Physiol. 2008, 104:1418-1425.
15. Lovering A.T., Stickland M.K., Amann M., Murphy J.C., O'Brien M.J., Hokanson J.S., Eldridge M.W. Hyperoxia prevents exercise-induced intrapulmonary arteriovenous shunt in healthy humans. J. Physiol. 2008, 586:4559-4565.
16. Lovering A.T., Stickland M.K., Eldridge M.W. Intrapulmonary shunt during normoxic and hypoxic exercise in healthy humans. Adv. Exp. Med. Biol. 2006, 588:31-45.
17. Lovering A.T., Stickland M.K., Kelso A.J., Eldridge M.W. Direct demonstration of 25- and 50-microm arteriovenous pathways in healthy human and baboon lungs. Am. J. Physiol. 2007, 292:H1777-H1781.
18. Muneyuki M., Urabe N., Kato H., Shirai K., Ueda Y., Inamoto A. The effects of catecholamines on arterial oxygen tension and pulmonary shunting during the postoperative period in man. Anesthesiology 1971, 34:356-364.
19. Naeije R., Faoro V. Pathophysiological insight into shunted bubbles. J. Appl. Physiol. 2009, 107:999-1000.
20. Quanjer P.H., Tammeling G.J., Cotes J.E., Pedersen O.F., Peslin R., Yernault J.C. Lung volumes and forced ventilatory flows. Report working party standardization of lung function tests, european community for steel and coal. official statement of the european respiratory society. Eur. Respir. J. Suppl. 1993, 16:5-40.
21. Richards J.C., McKenzie D.C., Warburton D.E., Road J.D., Sheel A.W. Prevalence of exercise-induced arterial hypoxemia in healthy women. Med. Sci. Sport Exerc. 2004, 36:1514-1521.
22. Rodriguez-Roisin R., Agusti A.G., Roca J. The hepatopulmonary syndrome: new name, old complexities. Thorax 1992, 47:897-902.
23. Stickland M.K., Lovering A.T. Exercise-induced intrapulmonary arteriovenous shunting and pulmonary gas exchange. Exerc. Sport Sci. Rev. 2006, 34:99-106.
24. Stickland M.K., Welsh R.C., Haykowsky M.J., Petersen S.R., Anderson W.D., Taylor D.A., Bouffard M., Jones R.L. Intra-pulmonary shunt and pulmonary gas exchange during exercise in humans. J. Physiol. 2004, 561:321-329.
25. Strauss H.W., Hurley P.J., Rhodes B.A., Wagner H.N. Quantification of right-to-left transpulmonary shunts in man. J. Lab. Clin. Med. 1969, 74:597-607.
26. Tobin C.E. Arteriovenous shunts in the peropheral pulmonary circulation in the human lung. Thorax 1966, 21:197-204.
27. Tobin C.E., Zariquiey M.O. Arteriovenous shunts in the human lung. Proc. Soc. Exp. Biol. Med. 1950, 75:827-829.
28. West J.B., Mathieu-Costello O. Stress failure of pulmonary capillaries as a limiting factor for maximal exercise. Eur. J. Appl. Physiol. 1995, 70:99-108.
29. Whyte M.K., Peters A.M., Hughes J.M., Henderson B.L., Bellingan G.J., Jackson J.E., Chilvers E.R. Quantification of right to left shunt at rest and during exercise in patients with pulmonary arteriovenous malformations. Thorax 1992, 47:790-796.
30. Woods T.D., Harmann L., Purath T., Ramamurthy S., Subramanian S., Jackson S., Tarima S. Small- and moderate-size right-to-left shunts identified by saline contrast echocardiography are normal and unrelated to migraine headache. Chest 2010, 138:264-269.
31. Woods T.D., Patel A. A critical review of patent foramen ovale detection using saline contrast echocardiography: when bubbles lie. J. Am. Soc. Echocardiogr. 2006, 19:215-222.